Results 121 to 130 of about 269,063 (304)

A single event transient hardening circuit design technique based on strengthening

, 2013
In a near future of high-density and low-power technologies, the study of soft errors will not only be relevant for memory systems and latches of logic circuits, but also for the combinational parts of logic circuits which seriously affect the system's ...
Amat Bertran, Esteve, Calomarde Palomino, Antonio, Moll Echeto, Francisco de Borja, Rubio Sola, Jose Antonio   +3 more
core   +1 more source

The Atacama Cosmology Telescope: Systematic Transient Search of Single Observation Maps

The Astrophysical Journal
We conduct a systematic search for astrophysical transients using data from the Atacama Cosmology Telescope. The data were taken from 2017 to 2022 in three frequency bands spanning 77 to 277 GHz.
Emily Biermann, Yaqiong Li, Sigurd Naess, Steve K. Choi, Susan E. Clark, Mark Devlin, Jo Dunkley, P. A. Gallardo, Yilun Guan, Allen Foster, Matthew Hasselfield, Carlos Hervías-Caimapo, Matt Hilton, Adam D. Hincks, Anna Y. Q. Ho, John C. Hood II, Kevin M. Huffenberger, Arthur Kosowsky, Michael D. Niemack, John Orlowski-Scherer, Lyman Page, Bruce Partridge, Maria Salatino, Cristóbal Sifón, Suzanne T. Staggs, Cristian Vargas, Edward J. Wollack   +26 more
doaj   +1 more source

A Procedure for Fast Circuit Cross Section Estimation

Chips
Semiconductor technologies are susceptible to radiation effects. The particle incidence in susceptible areas of an integrated circuit (IC) can generate physical interactions capable of producing errors.
Clayton R. Farias, Tiago R. Balen, Paulo F. Butzen   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Single-event transient analysis on radiation-hardened SiGe and GaN ringfet’s using 3D TCAD simulations

Discover Materials
The ringFET devices are investigated for radiation-hardened applications employing advanced semiconductor materials such as SiGe and GaN by conducting 3D TCAD simulations.
M. Ramya, K. K. Nagarajan, R. Binowesley, A. J. Bhuvaneshwari, P. Kaythry, K. J. Jegadish Kumar, R. Vinu, C. Parthasarathy, S. Gomathi   +8 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Single-Event Transient Testing of the Crane Aerospace and Electronics SMHF2812D Dual DC-DC Converter

, 2015
The purpose of this testing was to characterize the Crane Aerospace & Electronics (Crane) Interpoint SMHF2812D for single-event transient (SET) susceptibility.
Casey, Megan
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source