Results 61 to 70 of about 269,063 (304)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Particle swarm optimisation driven low cost single event transient fault secured design during architectural synthesis

The Journal of Engineering, 2017
Owing to aggressive shrinking in nanometre scale as well as faster devices, particle strike manifesting itself into transient fault spanning multiple cycle and multiple units will be the centre-focus of application specific datapath generated through ...
Anirban Sengupta, Deepak Kachave
doaj   +1 more source

Study on Single Event Effects of Enhanced GaN HEMT Devices under Various Conditions

Micromachines
GaN HEMT devices are sensitive to the single event effect (SEE) caused by heavy ions, and their reliability affects the safe use of space equipment. In this work, a Ge ion (LET = 37 MeV·cm2/mg) and Bi ion (LET = 98 MeV·cm2/mg) were used to irradiate ...
Xinxiang Zhang, Yanrong Cao, Chuan Chen, Linshan Wu, Zhiheng Wang, Shuo Su, Weiwei Zhang, Ling Lv, Xuefeng Zheng, Wenchao Tian, Xiaohua Ma, Yue Hao   +11 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Transient plasma injections in the dayside magnetosphere: One-to-one correlated observations by cluster and by SuperDARN [PDF]

, 2004
Conjunctions in the cusp between the four Cluster spacecraft and SuperDARN ground-based radars offer unique opportunities to compare the signatures of transient plasma injections simultaneously in the high-altitude dayside magnetosphere and in the ...
Laakso, H., J.-M. Bosqued, Förster, M., Foerster, M., H. Laakso (7591349), Fontaine, D., Cerisier, J. C., J.-C. Cerisier, A. Marchaudon (7650635), Fontaine, Dominique, J. A. Wild (7591442), Bosqued, J.-M., Décréau, Pierrette, P. M. E. Décréau (7651646), Dunlop, M., Wild, J., M. W. Dunlop, Bosqued, J., Bosqued, J. M., Marchaudon, A., Dunlop, M. W., Cerisier, J., A. Marchaudon, P. M. E. Décréau, M. W. Dunlop (7591493), H. Laakso, Marchaudon, Aurélie, Wild, J. A., J. A. Wild, Décréau, P. M. E., J.-M. Bosqued (7685081), D. Fontaine, M. Förster, Décréau, P., M. Förster (2934723), J.-C. Cerisier (7685078), D. Fontaine (7685084), Cerisier, J.-C.   +37 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Analysis of Single Event Transient in SOI GaN-Based FinFET Due to Heavy-Ion Irradiation

IEEE Access
GaN devices offer unrivaled efficiency, high-frequency performance, and superior radiation tolerance over traditional silicon technologies, making them well-suited for space applications.
P. S. Rajakumar, S. Satheesh Kumar
doaj   +1 more source

Analysis of SET Reconvergence and Hardening in the Combinational Circuit Using a SAT-Based Method

IEEE Access, 2018
The reconvergence-phenomenon is common in modern circuit design. It occurs when the signal reconvenes at a certain point through multiple sensitized paths. It affects the soft error estimation and hardening. It is complicated to analyze the reconvergence-
Chang Liu, Long Zhang, Xu He, Yang Guo
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source