Results 101 to 110 of about 479,986 (210)

Towards an optoelectronic characterization of molecules by nanoscale gold antennas [PDF]

, 2014
Molecular electronics and plasmonics are both very promising fields in nanoscale sciences in which their combination is a big challenge. This thesis is divided into two parts.
Fröhlich, Toni
core   +1 more source

Complementary approaches to target human respiratory syncytial virus using small molecule ligands [PDF]

, 2012
In the current project, situated at the interface of chemistry and virology, complementary drug discovery approaches (high-throughput screening and structurebased drug design) have been exploited in order to discover novel small molecule inhibitors of ...
Lardeau, Charles-Hugues Claude Jean
core  

Precision Optical Measurements of DNA Structure and Synthesis [PDF]

, 2007
The structure and synthesis of DNA is important. Traditionally,high-resolution structures are solved with X-ray crystallography, and kinetic measurements are taken with consumption of large amount of reagents.
Ziyang Ma, Ma, Ziyang
core   +1 more source

Fast quantitative single-molecule detection at ultralow concentrations

, 2010
The applicability of single-molecule fluorescence assays in liquids is limited by diffusion to concentrations in the low picomolar range. Here, we demonstrate quantitative single-molecule detection at attomolar concentrations within 1 min by excitation ...
Hegner, M., Calame, M., Philippe Haas, Flammer, Josef, Hecht, Bert, Michel Calame, Wilfried Grange, Zorman, Sylvain, Martin Hegner, Haas, P., Zorman, S., Hecht, B., Aebi, U., Calame, Michel, Sylvain Zorman, Ueli Aebi, Haas, Philippe, Wild, Andreas, Josef Flammer, Then, P., Patrick Then, Aebi, Ueli, Andreas Wild, Flammer, J., Hegner, Martin, Grange, Wilfried, Then, Patrick, Wild, A., Grange, W., Bert Hecht   +29 more
core   +1 more source

Single-molecule enzymology: what can it tell us?

, 2003
In the last decade, several methods have been developed to measure enzyme activity at the level of a single enzyme molecule. This represents a considerable technical feat, but what does it allow us to learn about enzymes?
Clive R. Bagshaw (1271121)
core  

Fast Quantitative Single-Molecule Detection at Ultralow Concentrations

, 2016
The applicability of single-molecule fluorescence assays in liquids is limited by diffusion to concentrations in the low picomolar range. Here, we demonstrate quantitative single-molecule detection at attomolar concentrations within 1 min by excitation ...
Bert Hecht (1511635), Wilfried Grange (41747), Josef Flammer (220885), Patrick Then (2284795), Andreas Wild (1652911), Ueli Aebi (2284792), Philippe Haas (2284789), Michel Calame (1546447), Sylvain Zorman (2284786), Martin Hegner (41752)   +9 more
core   +1 more source

Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes

Microbial Cell, 2019
Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. In vivo, many of such changes are studies using reporters for specific types of changes, or through cytological studies that detect changes at the single ...
Hannah L Klein, Kenny K.H. Ang, Michelle R. Arkin, Emily C. Beckwitt, Yi-Hsuan Chang, Jun Fan, Youngho Kwon, Michael J. Morten, Sucheta Mukherjee, Oliver J. Pambos, Hafez el Sayyed, Elizabeth S. Thrall, João P. Vieira-da-Rocha, Quan Wang, Shuang Wang, Hsin-Yi Yeh, Julie S. Biteen, Peter Chi, Wolf-Dietrich Heyer, Achillefs N. Kapanidis, Joseph J. Loparo, Terence R. Strick, Patrick Sung, Bennett Van Houten, Hengyao Niu, Eli Rothenberg   +25 more
doaj   +1 more source

Expanding the Dynamic Range of Fluorescence Assays through Single-Molecule Counting and Intensity Calibration

, 2018
Surface capture assays can measure fluorescently labeled analytes across a 1000-fold concentration range and at the sub-nanomolar level, but many biological molecules exhibit 1,000,000-fold variations in abundance down to the femtomolar level.
Manish Kohli, Lucas Smith (5851823), Lucas Smith, Andrew M. Smith, Andrew M. Smith (251118), Manish Kohli (840010)   +5 more
core   +1 more source

LRRK2RCKW single molecule kinesin motility assays v1

, 2020
This protocol is about LRRK2RCKW single molecule kinesin motility assays.
openaire   +1 more source

Recent Advance in Single-Molecule Fluorescent Biosensors for Tumor Biomarker Detection

Biosensors
The construction of biosensors for specific, sensitive, and rapid detection of tumor biomarkers significantly contributes to biomedical research and early cancer diagnosis.
Jie Zhang, Jiawen Liu, Lixue Qiao, Qian Zhang, Juan Hu, Chun-yang Zhang   +5 more
doaj   +1 more source