Results 231 to 240 of about 367,917 (307)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Molecular Characterization and Protective Efficacy of a Novel Protein (EnSSB) Containing a Single-Stranded DNA-Binding Domain from <i>Eimeria necatrix</i>. [PDF]

Animals (Basel)
Zhu Y, Liu D, Wang L, Feng Q, Xue N, Hou Z, Xu J, Tao J.   +7 more
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Single-molecule fluorescence reveals the DNA unwinding mechanism of mitochondrial helicase TWINKLE and its interplay with single-stranded DNA-binding proteins. [PDF]

Nucleic Acids Res
Wang HY, Lee YY, Chien PJ, Tsai WA, Sun PJ, Wang LT, Wu CC, Fan HF.   +7 more
europepmc   +1 more source

Single-Stranded DNA Gap Accumulation Is a Functional Biomarker for USP1 Inhibitor Sensitivity. [PDF]

Cancer Res
da Costa AA, Somuncu O, Ravindranathan R, Mukkavalli S, Martignetti DB, Nguyen H, Jiao Y, Lamarre BP, Sadatrezaei G, Moreau L, Liu J, Iyer DR, Lazaro JB, Shapiro GI, Parmar K, D'Andrea AD.   +15 more
europepmc   +1 more source

The concentration of single-stranded DNA-binding proteins is a critical factor in recombinase polymerase amplification (RPA), as revealed by insights from an open-source system. [PDF]

PeerJ
Cordoba-Andrade F, Peralta-Castro A, García-Medel PL, Castro-Torres E, Gonzalez-Gonzalez R, Castro-Lara AY, Mora Garduño JD, Raygoza CD, Baruch-Torres N, Peñafiel-Ayala A, Diaz-Quezada C, Cardona-Felix CS, Guzman Chavez F, Trasviña-Arenas CH, Sotelo-Mundo RR, Xoconostle-Cazares B, Martínez-Antonio A, Brieba de Castro LG.   +17 more
europepmc   +1 more source

Stabilization of a single-stranded DNA of adeno-associated virus by inverted terminal repeats. [PDF]

Sci Rep
Yuan Y, Higashiyama K, Ito-Kudo E, Masumi-Koizumi K, Yusa K, Uchida K.   +5 more
europepmc   +1 more source

Fast and efficient method for parallel construction of targeted exome and methylome single-stranded DNA sequencing libraries. [PDF]

Sci Rep
Kim E, An S, Ahn H, Lim J, Kim SK, Park AK.   +5 more
europepmc   +1 more source

Super-resolution imaging reveals nucleolar encapsulation by single-stranded DNA. [PDF]

J Cell Sci
Maki K, Fukute J, Adachi T.
europepmc   +1 more source

Hypermutation in single-stranded DNA

DNA Repair, 2020
Regions of genomic DNA can become single-stranded in the course of normal replication and transcription as well as during DNA repair. Abnormal repair and replication intermediates can contain large stretches of persistent single-stranded DNA, which is extremely vulnerable to DNA damaging agents and hypermutation.
Natalie Saini, Dmitry A Gordenin
exaly   +4 more sources