Results 41 to 50 of about 852,815 (296)

A fully human inhibitory monoclonal antibody to the Wnt receptor RYK. [PDF]

PLoS ONE, 2013
RYK is an unusual member of the receptor tyrosine kinase (RTK) family that is classified as a putative pseudokinase. RYK regulates fundamental biological processes including cell differentiation, migration and target selection, axon outgrowth and ...
Michael M Halford, Maria L Macheda, Clare L Parish, Elena A Takano, Stephen Fox, Daniel Layton, Edouard Nice, Steven A Stacker   +7 more
doaj   +1 more source

Generation and utility of a single-chain fragment variable monoclonal antibody platform against a baculovirus expressed recombinant receptor binding domain of SARS-CoV-2 spike protein

Molecular Immunology, 2022
As the second wave of COVID-19 launched, various variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have emerged with a dramatic global spread amongst millions of people causing unprecedented case fatalities and economic shut-downs. That initiated a necessity for developing specific diagnostics and therapeutics along with vaccines
Reda Salem, Alaa A. El-Kholy, Fatma R. Waly, Dalia Ayman, Aya Sakr, Mai Hussein   +5 more
openaire   +2 more sources

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

Frontiers in Immunology, 2017
Molecular engineering to increase the percentage identity to common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice.
John Steven, Mischa R. Müller, Miguel F. Carvalho, Obinna C. Ubah, Marina Kovaleva, Gerard Donohoe, Thomas Baddeley, Dawn Cornock, Kenneth Saunders, Andrew J. Porter, Andrew J. Porter, Caroline Jane Barelle   +11 more
doaj   +1 more source

Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats

mAbs, 2023
Bispecific antibodies (bsAbs) enable dual binding of different antigens with potential synergistic targeting effects and innovative therapeutic possibilities.
Andreas V. Madsen, Peter Kristensen, Alexander K. Buell, Steffen Goletz   +3 more
doaj   +1 more source

Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT

Frontiers in Immunology, 2023
IntroductionT cell Ig and ITIM domain receptor (TIGIT) is a next-generation immune checkpoint predominantly expressed on activated T cells and NK cells, exhibiting an unfavorable prognostic association with various malignancies.
Katty Zeven, Timo W.M. De Groof, Hannelore Ceuppens, Robin Maximilian Awad, Thomas Ertveldt, Wout de Mey, Fien Meeus, Geert Raes, Geert Raes, Karine Breckpot, Nick Devoogdt   +10 more
doaj   +1 more source

Use of single-chain antibody derivatives for targeted drug delivery [PDF]

, 2016
Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery.
Ahmadzadeh, V., Erfani-Moghadam, V., Jaliani, H.Z., Khalili, M., Safdari, Y., Zarei, V.   +5 more
core   +1 more source

Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides [PDF]

, 1993
Synthetic peptides of the five alternative NH2-terminal sequences of Shaker when applied to the cytoplasmic side of ShB channels that have an NH2-terminal deletion (ShB delta 6-46) block the channel with potencies correlated with the rate of inactivation
Aldrich, Richard W, Murrell-Lagnado, Ruth D   +1 more
core   +3 more sources

Two time constants for the binding of proteins to DNA from micromechanical data [PDF]

, 2000
Recent experimental advances allow the direct measurement of the force/extension behavior for DNA in the presence of strongly binding proteins. Such experiments reveal information about the cooperative mechanism of protein binding.
Turner, Matthew S.
core   +2 more sources

A novel efficient bispecific antibody format, combining a conventional antigen-binding fragment with a single domain antibody, avoids potential heavy-light chain mis-pairing

Journal of Immunological Methods, 2020
Due to the technical innovations in generating bispecific antibodies (BsAbs) in recent years, BsAbs have become important reagents for diagnostic and therapeutic applications. However, the difficulty of producing a heterodimer consisting of two different arms with high yield and purity constituted a major limitation for their application in academic ...
Huang, Shuyu, Segués, Aina, Hulsik, David Lutje, Zaiss, Dietmar M., Sijts, Alice J.A.M., van Duijnhoven, Sander M.J., van Elsas, Andrea   +6 more
openaire   +4 more sources

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity [PDF]

, 2008
Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected.
Bugg, Charles W., Dunn, Denise E., Khoshnan, Ali, Lo, Donald C., Patterson, Paul H., Southwell, Amber L.   +5 more
core   +2 more sources