Results 61 to 70 of about 852,815 (296)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Single chain dimers of MASH-1 bind DNA with enhanced affinity [PDF]

, 2017
By designing recombinant genes containing tandem copies of the coding region of the BHLH domain of MASH-1 (MASH-BHLH) with intervening DNA sequences encoding linker sequences of 8 or 17 amino acids, the two subunits of the MASH dimer have been connected ...
Allemann, Rudolf K., Sieber, Martin
core  

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family [PDF]

, 2013
Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions.
A Arvand, A Bertolotti, A Bhattacherjee, A Boro, A Zarrine-Afsar, AB Sigalov, AG Turjanski, AH Mao, AH Mao, AK Dunker, AS Mahadevi, AS Reddy, AS Reddy, AY Tan, BA Shoemaker, C Haynes, D Alex, D Vijay, ED Ross, F Jin, G Gill, GM Lee, Guanghong Wei, HJ Dyson, HS Ashbaugh, HS Chan, HS Chan, Hue Sun Chan, HV Erkizan, HV Erkizan, I Staneva, J Danielsson, J Kim, J Singh, J Wang, J Wang, JC Hansen, JC Ma, JF Rual, Jianhui Song, JMR Baker, JP Gallivan, JP Gallivan, JS Barber-Rotenberg, JS Rao, JW Caldwell, Kevin A. W. Lee, KP Ng, KP Ng, KP Ng, L Feng, LM Iakoucheva, LM Salonen, M Azuma, M Borg, M Fuxreiter, M Levitt, MA Pufall, MS Cortese, MS Marshall, P Nash, P Tompa, P Tompa, PB Crowley, Peter Tompa, PJ Grohar, Q Lu, R Bachmaier, R Janknecht, R Petermann, R Wu, S Abeln, Sheung Chun Ng, SK Burley, SM Butterfield, T Mittag, T Mittag, V Neduva, VJ Hilser, VN Uversky, W Wang, W Zhong, X Chu, X Chu, X Xiu, Y Huang, Y Huang, Y Huang, Z Zhang   +88 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery

mAbs
Heavy chain-only antibodies have found many applications where conventional heavy-light heterodimeric antibodies are not favorable. Heavy chain-only antibodies with their single antigen-binding domain offer the advantage of a smaller size and higher ...
Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton   +19 more
doaj   +1 more source

Nanobody based dual specific CARs [PDF]

, 2018
Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas.
Abken, Hinrich, Bonte, Sarah, De Munter, Stijn, Goetgeluk, Glenn, Ingels, Joline, Kerre, Tessa, Pille, Melissa, Vandekerckhove, Bart, Weening, Karin   +8 more
core   +2 more sources

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. [PDF]

Proceedings of the National Academy of Sciences, 1993
The generation of tumor-specific lymphocytes and their use in adoptive immunotherapy is limited to a few malignancies because most spontaneous tumors are very weak or not at all immunogenic. On the other hand, many anti-tumor antibodies have been described which bind tumor-associated antigens shared among tumors of the same histology.
Z, Eshhar, T, Waks, G, Gross, D G, Schindler   +3 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly. [PDF]

PLoS ONE, 2016
The clathrin heavy chain N-terminal domain interacts with endocytic adapter proteins via clathrin binding motifs to assemble clathrin triskelia into cages. However, the precise mechanism of clathrin assembly is not yet known.
Lia Moshkanbaryans, Jing Xue, Jesse Ray Wark, Phillip James Robinson, Mark Evan Graham   +4 more
doaj   +1 more source

A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common β-Chain Is Necessary and Sufficient for High Affinity Binding and Signaling by All Three Ligands [PDF]

Journal of Biological Chemistry, 1996
The beta-chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) receptors functions as a communal receptor subunit and is often referred to as beta common (betac). Analogous to other shared receptor subunits including gp130 and the IL-2R gamma chain, betac mediates high affinity binding ...
J M, Woodcock, C J, Bagley, B, Zacharakis, A F, Lopez   +3 more
openaire   +2 more sources