Results 21 to 30 of about 1,169,281 (338)

A new treatment for canine B-cell lymphoma based on a recombinant single-domain antibody immunotoxin derived from <i>Pseudomonas aeruginosa</i> exotoxin A. [PDF]

Front Vet Sci
André AS, Dias JNR, Moutinho I, Loureiro J, Leonardo A, Nogueira S, Marimon RP, Bule P, Correia J, Malhó R, Gano L, Correia JDG, Gil S, Gonçalves J, Pastan I, Tavares L, Aires-da-Silva F.   +16 more
europepmc   +2 more sources

Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha. [PDF]

RSC Chem Biol
Xu Z, Sinha A, Pandya DN, Schnicker NJ, Wadas TJ.   +4 more
europepmc   +3 more sources

Site-Specifically Conjugated Single-Domain Antibody Successfully Identifies Glypican-3–Expressing Liver Cancer by Immuno-PET

Journal of Nuclear Medicine, 2023
Visual Abstract Primary liver cancer is the third leading cause of cancer-related deaths, and its incidence and mortality are increasing worldwide. Hepatocellular carcinoma (HCC) accounts for 80% of primary liver cancer cases.
S. Fayn, A. King, N. Gutsche, Zhijian Duan, J. Buffington, C. Olkowski, Ying Fu, Jessica Hong, D. Sail, K. Baidoo, R. Swenson, R. W. Cheloha, Mitchell Ho, Peter Choyke, Freddy E. Escorcia   +14 more
semanticscholar   +1 more source

mRNA Delivery of a Bispecific Single‐Domain Antibody to Polarize Tumor‐Associated Macrophages and Synergize Immunotherapy against Liver Malignancies

Advances in Materials, 2021
Liver malignancies are among the tumor types that are resistant to immune checkpoint inhibition therapy. Tumor‐associated macrophages (TAMs) are highly enriched and play a major role in inducing immunosuppression in liver malignancies.
Ying Wang, Karthik Tiruthani, Sirui Li, Mengying Hu, Guojie Zhong, Yu Tang, Sourav Roy, Lillian Zhang, Jun Tan, Chengheng Liao, Rihe Liu   +10 more
semanticscholar   +1 more source

Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor

Pharmaceutics, 2022
The ability of drugs and therapeutic antibodies to reach central nervous system (CNS) targets is greatly diminished by the blood–brain barrier (BBB). Receptor-mediated transcytosis (RMT), which is responsible for the transport of natural protein ligands ...
Á. Yogi, G. Hussack, H. van Faassen, A. Haqqani, Christie E. Delaney, Eric Brunette, J. Sandhu, M. Hewitt, T. Sulea, K. Kemmerich, D. Stanimirovic   +10 more
semanticscholar   +1 more source

Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers

Scientific Reports, 2022
Radiopharmaceutical therapy (RPT) is an attractive strategy for treatment of disseminated cancers including those overexpressing the HER2 receptor including breast, ovarian and gastroesophageal carcinomas.
Yutian Feng, Rebecca Meshaw, Darryl McDougald, Zhengyuan Zhou, Xiaoguang Zhao, Stephen A. Jannetti, Robert E. Reiman, Erica Pippen, Robin Marjoram, J. Schaal, G. Vaidyanathan, M R Zalutsky   +11 more
semanticscholar   +1 more source

Preparation and identification of a single domain antibody specific for adenovirus vectors and its application to the immunoaffinity purification of adenoviruses

AMB Express, 2022
Adenovirus belongs to the family of Adenoviridae. As a vaccine carrier, it has high safety and stimulates the body to produce cellular immunity and humoral immunity.
Yi Cheng, Yanxia Hao, Fuxiang Bao, Huimin Zhang, Yanlong Liu, Kexin Ao, Shan Fu, Qiyao Wu, Zhi Wang   +8 more
doaj   +1 more source

Novel single-domain antibodies against the EGFR domain III epitope exhibit the anti-tumor effect

Journal of Translational Medicine, 2020
Background Monoclonal antibodies (mAbs) have been used for cancer therapy. They are large and have some disadvantages limiting their use. Smaller antibody fragments are needed as their alternatives. A fully human single-domain antibody (sdAb) has a small
Tao Chen, Xue Liu, Haifeng Hong, Henry Wei   +3 more
doaj   +1 more source

Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness

Antibodies, 2023
Driven by necessity, the COVID-19 pandemic caused by SARS-CoV-2 has accelerated the development and implementation of new vaccine platforms and other viral therapeutics. Among these is the therapeutic use of antibodies including single-domain antibodies,
Janet M. Daly, Theam Soon Lim, Kevin C. Gough   +2 more
doaj   +1 more source

Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A

bioRxiv, 2022
Single-domain antibodies (sdAbs, VHHs, or nanobodies) are a promising tool for the treatment of both infectious and somatic diseases. Their small size greatly simplifies any genetic engineering manipulations. Such antibodies have the ability to bind hard-
Eugenia A. Panova, D. Kleymenov, D. Shcheblyakov, E. Bykonia, E. Mazunina, A. Dzharullaeva, Anastasia N. Zolotar, A. A. Derkaev, I. Esmagambetov, Ivan I. Sorokin, E. Usachev, Igor A. Ivanov, T. Zatsepin, S. Dmitriev, V. Gushchin, D. Logunov, A. Gintsburg   +16 more
semanticscholar   +1 more source