Results 11 to 20 of about 71,811 (209)
Surface Modification of Fluorescent Nanodiamonds for Biological Applications
Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility.
Hak-Sung Jung, Keir C. Neuman
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Confined environment facilitates stacked conformations in Holliday Junction
Holliday Junction (HJ) is an important intermediate in homologous recombination and is involved in DNA break repair. It is a highly dynamic structure and transitions between two stacked isomers through an intermediate open conformer. However, the insight
Priya Agarwal +2 more
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Topoisomerase VI is a chirally-selective, preferential DNA decatenase
DNA topoisomerase VI (topo VI) is a type IIB DNA topoisomerase found predominantly in archaea and some bacteria, but also in plants and algae. Since its discovery, topo VI has been proposed to be a DNA decatenase; however, robust evidence and a mechanism
Shannon J McKie +5 more
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Single-molecule biophysics: at the interface of biology, physics and chemistry [PDF]
Edward A Lemke +2 more
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General Method to Increase Carboxylic Acid Content on Nanodiamonds
Carboxylic acid is a commonly utilized functional group for covalent surface conjugation of carbon nanoparticles that is typically generated by acid oxidation.
Ganesh Shenoy +11 more
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The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo +8 more
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Single Particle Tracking (SPT) is a powerful class of methods for studying the dynamics of biomolecules inside living cells. The techniques reveal the trajectories of individual particles, with a resolution well below the diffraction limit of light, and ...
Boris I. Godoy +2 more
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Viruses and Tetraspanins: Lessons from Single Molecule Approaches
Tetraspanins are four-span membrane proteins that are widely distributed in multi-cellular organisms and involved in several infectious diseases. They have the unique property to form a network of protein-protein interaction within the plasma membrane ...
Selma Dahmane +2 more
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Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc<sub>1</sub>. [PDF]
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Wójcik-Augustyn A +2 more
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Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
Repair of DNA double strand breaks (DSBs) is integral to preserving genomic integrity. Therefore, defining the mechanisms underlying DSB repair will enhance our understanding of how defects in these pathways contribute to human disease and could lead to ...
Joshua R Heyza +4 more
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