Results 11 to 20 of about 70,987 (292)

Single-molecule biophysics: at the interface of biology, physics and chemistry. [PDF]

open access: yesJ R Soc Interface, 2008
Single-molecule methods have matured into powerful and popular tools to probe the complex behaviour of biological molecules, due to their unique abilities to probe molecular structure, dynamics and function, unhindered by the averaging inherent in ensemble experiments.
Deniz AA, Mukhopadhyay S, Lemke EA.
europepmc   +5 more sources

Single-molecule biophysics [PDF]

open access: yesContemporary Physics
Biological molecules, like all active matter, use free energy to generate force and motion which drive them out of thermal equilibrium, and undergo inherent dynamic interconversion between metastable free energy states separated by levels barely higher ...
Leake, Mark Christian
core   +4 more sources

Handbook of Single-Molecule Biophysics [PDF]

open access: yes, 2009
The last decade has seen the development of a number of novel biophysical methods that allow the manipulation and study of individual biomolecules. The ability to monitor biological processes at this fundamental level of sensitivity has given rise to an ...
Oijen, Antoine, Hinterdorfer, Peter
core   +2 more sources

Advances in magnetic tweezers for single molecule and cell biophysics [PDF]

open access: yesIntegrative Biology, 2017
Magnetic tweezers (MTW) enable highly accurate forces to be transduced to molecules to study mechanotransduction at the molecular or cellular level. We review recent MTW studies in single molecule and cell biophysics that demonstrate the flexibility of ...
Kilinc, Devrim, Lee, Gil U.
core   +5 more sources

Single molecule DNA biophysics with atomic force microscopy [PDF]

open access: yesSingle Molecules, 2000
Anselmetti D, Fritz J, Smith B, Fernandez-Busquets X. Single molecule DNA biophysics with atomic force microscopy. Single molecules. 2000;1(1):53-58.Structural and functional properties of double stranded deoxyribonucleic acid (dsDNA) are investigated by
Fritz, Jürgen   +3 more
core   +4 more sources

Impact of Saccharomyces cerevisiae on the Field of Single-Molecule Biophysics. [PDF]

open access: yesInt J Mol Sci, 2022
Cellular functions depend on the dynamic assembly of protein regulator complexes at specific cellular locations. Single Molecule Tracking (SMT) is a method of choice for the biochemical characterization of protein dynamics in vitro and in vivo. SMT follows individual molecules in live cells and provides direct information about their behavior.
Ball DA, Jalloh B, Karpova TS.
europepmc   +3 more sources

Statistics and Related Topics in Single-Molecule Biophysics. [PDF]

open access: yesAnnu Rev Stat Appl, 2014
Since the universal acceptance of atoms and molecules as the fundamental constituents of matter in the early-twentieth century, molecular physics, chemistry, and molecular biology have all experienced major theoretical breakthroughs. Although researchers had to wait until the 1970s to see individual biological macromolecules one at a time in action ...
Qian H, Kou SC.
europepmc   +4 more sources

Decoding the Structural Dynamics and Conformational Alternations of DNA Secondary Structures by Single-Molecule FRET Microspectroscopy

open access: yesFrontiers in Molecular Biosciences, 2021
In addition to the canonical double helix form, DNA is known to be extrapolated into several other secondary structural patterns involving themselves in inter- and intramolecular type hydrogen bonding. The secondary structures of nucleic acids go through
Debolina Bandyopadhyay   +3 more
doaj   +1 more source

A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures

open access: yesNature Communications, 2021
Ring ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor ...
Juan P. Castillo   +4 more
doaj   +1 more source

Surface Modification of Fluorescent Nanodiamonds for Biological Applications

open access: yesNanomaterials, 2021
Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility.
Hak-Sung Jung, Keir C. Neuman
doaj   +1 more source

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