Results 21 to 30 of about 69,820 (250)

General Method to Increase Carboxylic Acid Content on Nanodiamonds

Molecules, 2022
Carboxylic acid is a commonly utilized functional group for covalent surface conjugation of carbon nanoparticles that is typically generated by acid oxidation.
Ganesh Shenoy, Jessica Ettedgui, Chandrasekhar Mushti, Jennifer Hong, Kelly Lane, Burchelle Blackman, Hak-Sung Jung, Yasuharu Takagi, Yeonee Seol, Martin Brechbiel, Rolf E. Swenson, Keir C. Neuman   +11 more
doaj   +1 more source

Magnetic nanoparticle-based solid phase peptide synthesis and the synchronous detection of their biological activity

Materials Today Advances, 2021
The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo, P. Wang, Q. Zheng, R. Han, C. Shi, L. Wang, Y. Hong, Y. Liu, Y. Sha   +8 more
doaj   +1 more source

An Estimation Algorithm for General Linear Single Particle Tracking Models with Time-Varying Parameters

Molecules, 2021
Single Particle Tracking (SPT) is a powerful class of methods for studying the dynamics of biomolecules inside living cells. The techniques reveal the trajectories of individual particles, with a resolution well below the diffraction limit of light, and ...
Boris I. Godoy, Nicholas A. Vickers, Sean B. Andersson   +2 more
doaj   +1 more source

Viruses and Tetraspanins: Lessons from Single Molecule Approaches

Viruses, 2014
Tetraspanins are four-span membrane proteins that are widely distributed in multi-cellular organisms and involved in several infectious diseases. They have the unique property to form a network of protein-protein interaction within the plasma membrane ...
Selma Dahmane, Eric Rubinstein, Pierre-Emmanuel Milhiet   +2 more
doaj   +1 more source

Single-Molecule Cellular Biophysics [PDF]

Journal of Biomedical Optics, 2013
Research on single-molecule cellular biophysics is an emerging field that is rapidly advancing based on the development of new instrumentation and experimental designs. To understand complex biological systems, researchers require instrumentation and techniques that span many orders of scale.
openaire   +2 more sources

Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

eLife, 2023
Repair of DNA double strand breaks (DSBs) is integral to preserving genomic integrity. Therefore, defining the mechanisms underlying DSB repair will enhance our understanding of how defects in these pathways contribute to human disease and could lead to ...
Joshua R Heyza, Mariia Mikhova, Aastha Bahl, David G Broadbent, Jens C Schmidt   +4 more
doaj   +1 more source

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loops

Nature Communications, 2022
Human Bloom’s syndrome (BLM) helicase has a role in DNA repair, and BLM deficiency in humans is associated with chromosomal abnormalities. Here the authors employ solution biophysical assays to show BLM maintains a balance for disruption and ...
Gábor M. Harami, János Pálinkás, Yeonee Seol, Zoltán J. Kovács, Máté Gyimesi, Hajnalka Harami-Papp, Keir C. Neuman, Mihály Kovács   +7 more
doaj   +1 more source

Identification and quantification of within-burst dynamics in singly labeled single-molecule fluorescence lifetime experiments

Biophysical Reports, 2022
: Single-molecule spectroscopy has revolutionized molecular biophysics and provided means to probe how structural moieties within biomolecules spatially reorganize at different timescales.
Paul David Harris, Eitan Lerner
doaj   +1 more source

Preface: Special Topic on Single-Molecule Biophysics [PDF]

The Journal of Chemical Physics, 2018
Single-molecule measurements are now almost routinely used to study biological systems and processes. The scope of this special topic emphasizes the physics side of single-molecule observations, with the goal of highlighting new developments in physical techniques as well as conceptual insights that single-molecule measurements bring to biophysics ...
Makarov, Dmitrii E, Schuler, Benjamin
openaire   +4 more sources

Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike

eLife, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects cells through binding to angiotensin-converting enzyme 2 (ACE2). This interaction is mediated by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein.
Marco A Díaz-Salinas, Qi Li, Monir Ejemel, Leonid Yurkovetskiy, Jeremy Luban, Kuang Shen, Yang Wang, James B Munro   +7 more
doaj   +1 more source