Results 1 to 10 of about 302,587 (323)
Filtering of Ineffective siRNAs and Improved siRNA Design Tool [PDF]
Bioinformatics, 2004 Abstract Motivation: Short interfering RNAs (siRNAs) can be used to suppress gene expression and possess many potential applications in therapy, but how to design an effective siRNA is still not clear. Based on the MPI (Max-Planck-Institute) basic principles, a number of siRNA design tools have been developed recently.
Siu‐Ming Yiu +6 more
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Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia [PDF]
ImmunoAnalysis, 2022 Background: Ecto-5’-nucleotidase (CD73) is a membrane-bound enzyme that converts adenosine 5’-monophosphate into adenosine. It is proven that the presence of elevated levels of adenosine in the tumor microenvironment induces tumor growth while ...
Mohammad Sadeghi +5 more
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The plant siRNA landscape [PDF]
The Plant Cell, 2023 Abstract Whereas micro (mi)RNAs are considered the clean, noble side of the small RNA world, small interfering (si)RNAs are often seen as a noisy set of molecules whose barbarian acronyms reflect a large diversity of often elusive origins and functions. Twenty-five years after their discovery in plants, however, new classes of siRNAs are
Vaucheret, Hervé, Voinnet, Olivier
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Molecular Cell, 2004 An array of gene silencing pathways share a common early step: Dicer cleaves double-stranded RNA (dsRNA) into approximately 20-25 nucleotide fragments that direct the silencing machinery to specific targets. A recent report in Cell reveals how Dicer's two RNase III domains collaborate during dsRNA processing and sets the stage for a deeper ...
Erik J. Sontheimer, John W. Pham
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Targeted Delivery of siRNA [PDF]
BioMed Research International, 2006 Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier.
Oliveira, S. +2 more
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Beilstein Journal of Organic Chemistry, 2021 Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their
Christopher Liczner +4 more
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Role of non-coding RNAs in Dengue virus-host interaction
Frontiers in Bioscience-Scholar, 2021 Dengue is potentially a life-threatening arthropod-borne viral infection for which there are no known therapeutic agents till date. Early stage diagnosis of dengue infection is still lacking.
Deeksha Madhry +8 more
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Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy [PDF]
Chem. Eng. J. 340, 114-124 (2018), 2021 Mesoporous silica nanoparticles (MSNPs) have many potential applications in biomedical fields. However, when MSNPs are exposed to plasma, protein adsorption leads to opsonization and decreases blood circulation time. A new multifunctional nanodevice based on polyethylenimine (PEI) coated core-shell Fe3O4@SiO2 MSNPs with a zwitterionic 2 ...
arxiv +1 more source
Retrovirus-delivered siRNA [PDF]
BMC Biotechnology, 2002 The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene function in mammalian cells. However, high production costs limit this technology's utility for many laboratories and experimental situations.
Devroe, Eric, Silver, Pamela A.
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Chemistry & Biology, 2002 RNAi is routinely used to eliminate gene activity for experimental purposes. However, the precise molecular mechanism of RNAi is unknown. Recent papers partially illuminate this mechanism in human cells, advancing the potential application of RNAi toward the treatment of human disease.
Gopalakrishna Ramaswamy, Frank J. Slack
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