Results 1 to 10 of about 309,118 (147)

Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia [PDF]

ImmunoAnalysis, 2022
Background: Ecto-5’-nucleotidase (CD73) is a membrane-bound enzyme that converts adenosine 5’-monophosphate into adenosine. It is proven that the presence of elevated levels of adenosine in the tumor microenvironment induces tumor growth while ...
Mohammad Sadeghi, Mahsa Yousefi Bostanabad, Omid Abedi, Abbas Ali Hosseinpour Feizi, Ali Akbar Movasaghpour Akbari, Farhad Jadidi-Niaragh   +5 more
doaj   +1 more source

THE EFFECT OF SILENCING THE Tip60 GENE ON THE RESPONSE TO RADIOTHERAPY IN BREAST CANCER CELLS

Sabiad, 2022
One of the most important problems encountered in patients with triple-negative breast cancer (BC) treatment is the inadequate response of tumor tissue to treatment.
Ece Miser Salihoğlu, Bensu Karahalil, Sevgi Yardım Akaydın   +2 more
doaj   +1 more source

Effect of antiviral siRNAs on the production of cytokines in vitro

Тонкие химические технологии, 2022
Objectives. To evaluate the dynamics of the expression level of IL-1β and IL-28β (IFN-λ3) genes as a result of complex knockdown of some cellular genes, whose expression products play an important role in the reproduction of the influenza virus.Methods ...
A. V. Pak, E. A. Pashkov, N. D. Abramova, A. V. Poddubikov, F. G. Nagieva, E. A. Bogdanova, E. P. Pashkov, O. A. Svitich, V. V. Zverev   +8 more
doaj   +1 more source

Progress in RNA-targeting and Gene Editing Therapies for Transthyretin Amyloidosis Cardiomyopathy

罕见病研究, 2023
Transthyretin(TTR) protein is a tetramer protein, synthesized mainly by the liver. TTR can be misfolded and deposited as amyloid fibrilae and deposited in the myocardial interstroma leading to transthyroxin amyloidosis cardiomyopathy (ATTR-CM).
NIU Ziran, HU Yang, LIU Qingyang, MA Yuanyuan, LIU Jianing, LIU Xin, ZHANG Bo   +6 more
doaj   +1 more source

Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S]

Journal of Lipid Research, 2011
Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blocks ...
Brandon Ason, Samnang Tep, Jr. Harry R. Davis, Yiming Xu, Glen Tetzloff, Beverly Galinski, Ferdie Soriano, Natalya Dubinina, Lei Zhu, Alice Stefanni, Kenny K. Wong, Marija Tadin-Strapps, Steven R. Bartz, Brian Hubbard, Mollie Ranalletta, Alan B. Sachs, W. Michael Flanagan, Alison Strack, Nelly A. Kuklin   +18 more
doaj   +1 more source

Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

Molecular Therapy: Nucleic Acids, 2019
Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult.
Radu Mihaila, Dipali Ruhela, Beverly Galinski, Ananda Card, Mark Cancilla, Timothy Shadel, Jing Kang, Samnang Tep, Jie Wei, R. Matthew Haas, Jeremy Caldwell, W. Michael Flanagan, Nelly Kuklin, Elena Cherkaev, Brandon Ason   +14 more
doaj   +1 more source

Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing

Journal of Lipid Research, 2012
Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver ...
Samnang Tep, Radu Mihaila, Alexander Freeman, Victoria Pickering, Felicia Huynh, Marija Tadin-Strapps, Allison Stracks, Brian Hubbard, Jeremy Caldwell, W. Michael Flanagan, Nelly A. Kuklin, Brandon Ason   +11 more
doaj   +1 more source

Role of non-coding RNAs in Dengue virus-host interaction

Frontiers in Bioscience-Scholar, 2021
Dengue is potentially a life-threatening arthropod-borne viral infection for which there are no known therapeutic agents till date. Early stage diagnosis of dengue infection is still lacking.
Deeksha Madhry, Kush Kumar Pandey, Jaskaran Kaur, Yogita Rawat, Leena Sapra, Ravi Kumar Y.S., Rupesh K. Srivastava, Sankar Bhattacharyya, Bhupendra Verma   +8 more
doaj   +1 more source

siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids[S]

Journal of Lipid Research, 2011
Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE–/– and low density lipoprotein receptor (LDLr)–/– mice have been extensively used for studies of coronary atherosclerosis.
Marija Tadin-Strapps, Laurence B. Peterson, Anne-Marie Cumiskey, Raymond L. Rosa, Vivienne Halili Mendoza, Jose Castro-Perez, Oscar Puig, Liwen Zhang, Walter R. Strapps, Satyasri Yendluri, Lori Andrews, Victoria Pickering, Julie Rice, Lily Luo, Zhu Chen, Samnang Tep, Brandon Ason, Elizabeth Polizzi Somers, Alan B. Sachs, Steven R. Bartz, Jenny Tian, Jayne Chin, Brian K. Hubbard, Kenny K. Wong, Lyndon J. Mitnaul   +24 more
doaj   +1 more source

siRNA-optimized Modifications for Enhanced In Vivo Activity

Molecular Therapy: Nucleic Acids, 2012
Current modifications used in small interfering RNAs (siRNAs), such as 2’-methoxy (2’-OMe) and 2’-fluoro (2’-F), improve stability, specificity or immunogenic properties but do not improve potency.
Denise M Kenski, Gabor Butora, Aarron T Willingham, Abby J Cooper, Wenlang Fu, Ning Qi, Ferdie Soriano, Ian W Davies, W Michael Flanagan   +8 more
doaj   +1 more source