Results 101 to 110 of about 527,047 (339)

Strategies for Delivery of siRNAs to Ovarian Cancer Cells

Pharmaceutics, 2019
The unmet need for novel therapeutic options for ovarian cancer (OC) deserves further investigation. Among the different novel drugs, small interfering RNAs (siRNAs) are particularly attractive because of their specificity of action and efficacy, as ...
Rossella Farra, Matea Maruna, Francesca Perrone, Mario Grassi, Fabio Benedetti, Marianna Maddaloni, Maguie El Boustani, Salvo Parisi, Flavio Rizzolio, Giancarlo Forte, Fabrizio Zanconati, Maja Cemazar, Urska Kamensek, Barbara Dapas, Gabriele Grassi   +14 more
doaj   +1 more source

M2pep-Modified Cyclodextrin-siRNA Nanoparticles Modulate the Immunosuppressive Tumor Microenvironment for Prostate Cancer Therapy

, 2023
Yao Sun, Michael F. Cronin, Monique Culturato Padilha Mendonça, Jianfeng Guo, Caitríona M. O’Driscoll   +4 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression. [PDF]

, 2015
Phosphorylation of H2AX on Ser139 (γH2AX) after exposure to ionizing radiation produces nuclear foci that are detectable by immunofluorescence microscopy.
Andrais, Bonnie, Mirzayans, Razmik, Murray, David, Scott, April, Wang, Ying W, Weiss, Robert H   +5 more
core   +2 more sources

Macrophage‐targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis

, 2021
Yong Mou, Guorao Wu, Qi Wang, Ting Pan, Lei Zhang, Yongjian Xu, Weining Xiong, Qing Zhou, Yi Wang   +8 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

First Russian experience of treating dyslipidemia with siRNA drugs in patients after heart transplantation

Российский кардиологический журнал
Patients after heart transplantation (HT) are at very high risk for cardiovascular disease. Protocols for the management of heart recipients include the initiation of lipid-lowering therapy (LLT), regardless of sex, age and origin of heart failure. Given
M. A. Simonenko, A. S. Alieva, M. Yu. Sitnikova, P. A. Fedotov   +3 more
doaj   +1 more source

An RNAi-Based Control of Fusarium graminearum Infections Through Spraying of Long dsRNAs Involves a Plant Passage and Is Controlled by the Fungal Silencing Machinery [PDF]

, 2016
Meeting the increasing food and energy demands of a growing population will require the development of ground-breaking strategies that promote sustainable plant production.
Abdellatef, Eltayb, Biedenkopf, Dagmar, Cardoza, Vinitha, Furch, Alexandra, Goesmann, Alexander, Jelonek, Lukas, Johannsmeier, Jan, Koch, Aline, Kogel, Karl-Heinz, Linicus, Lukas, McMillan, John, Mentzel, Tobias, Rossbach, Oliver, Weber, Lennart   +13 more
core   +3 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]

, 2019
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F., Burghaus, Jana, Cao Ho, Thanh, Jürgensen, Lonny, Kamuf-Schenk, Verena, Katus, Hugo A., Kiper, Leon, Krull, Alexandros, Riechert, Eva, Schecker, Johannes, Stangl, Karl, Stangl, Verena, Völkers, Mirko, Wöltje, Kerstin, Zhang, Kevin Sun   +14 more
core   +1 more source