Results 11 to 20 of about 302,587 (323)
Progress in RNA-targeting and Gene Editing Therapies for Transthyretin Amyloidosis Cardiomyopathy
罕见病研究, 2023 Transthyretin(TTR) protein is a tetramer protein, synthesized mainly by the liver. TTR can be misfolded and deposited as amyloid fibrilae and deposited in the myocardial interstroma leading to transthyroxin amyloidosis cardiomyopathy (ATTR-CM).
NIU Ziran +6 more
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Dendrimers for siRNA Delivery [PDF]
Pharmaceuticals, 2013 Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups.
Swati Biswas, Vladimir P. Torchilin
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Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme [PDF]
Nanomedicine Journal, 2021 Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was studied on MCF-7/Sensitive and ...
Serap Yalcin, Ufuk Gündüz
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Effect of antiviral siRNAs on the production of cytokines in vitro
Тонкие химические технологии, 2022 Objectives. To evaluate the dynamics of the expression level of IL-1β and IL-28β (IFN-λ3) genes as a result of complex knockdown of some cellular genes, whose expression products play an important role in the reproduction of the influenza virus.Methods ...
A. V. Pak +8 more
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siRNA-optimized Modifications for Enhanced In Vivo Activity
Molecular Therapy: Nucleic Acids, 2012 Current modifications used in small interfering RNAs (siRNAs), such as 2’-methoxy (2’-OMe) and 2’-fluoro (2’-F), improve stability, specificity or immunogenic properties but do not improve potency.
Denise M Kenski +8 more
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Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA
Molecular Therapy: Nucleic Acids, 2017 Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary
Radu Mihaila +9 more
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Vaccines, 2020 The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a ...
Simona Kranjc Brezar +5 more
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Structure, 2004 AbstractA recent report (Ma et al., 2004) describes the crystal structure of a “mini-siRNA” bound to a PAZ domain.
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Addis Ababa/Finfinee: A Blueprint towards Twin-city Administration
Ethiopian Journal of the Social Sciences and Humanities, 2018 This article analyses the challenge of Addis Ababa´s double status – both as capital of Ethiopia and that of the Regional State of Oromia. It delves into the unresolved issue of the special interest of Oromia in Addis Ababa/Finfinnee.
Zelalem T. Sirna
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Unzipping and binding of small interfering RNA with single walled Carbon Nanotube: a platform for small interfering RNA delivery [PDF]
J. Chem. Phys. 136, 065106 (2012), 2012 In an effort to design efficient platform for siRNA delivery, we combine all atom classical and quantum simulations to study the binding of small interfering RNA (siRNA) by pristine single wall carbon nanotube (SWCNT). Our results show that siRNA strongly binds to SWCNT surface via unzipping its base-pairs and the propensity of unzipping increases with
arxiv +1 more source