Results 11 to 20 of about 614,319 (393)
Where should siRNAs go: applicable organs for siRNA drugs
Experimental & Molecular Medicine, 2023 RNA interference mediated by small interfering RNAs (siRNAs) has been exploited for the development of therapeutics. siRNAs can be a powerful therapeutic tool because the working mechanisms of siRNAs are straightforward. siRNAs determine targets based on
Insook Ahn, Chanhee S Kang, Jinju Han
semanticscholar +4 more sources
Filtering of Ineffective siRNAs and Improved siRNA Design Tool [PDF]
Bioinformatics, 2004 Abstract Motivation: Short interfering RNAs (siRNAs) can be used to suppress gene expression and possess many potential applications in therapy, but how to design an effective siRNA is still not clear. Based on the MPI (Max-Planck-Institute) basic principles, a number of siRNA design tools have been developed recently.
Siu‐Ming Yiu +6 more
openalex +7 more sources
Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia [PDF]
ImmunoAnalysis, 2022 Background: Ecto-5’-nucleotidase (CD73) is a membrane-bound enzyme that converts adenosine 5’-monophosphate into adenosine. It is proven that the presence of elevated levels of adenosine in the tumor microenvironment induces tumor growth while ...
Mohammad Sadeghi +5 more
doaj +1 more source
Therapeutic siRNA: State-of-the-Art and Future Perspectives
BioDrugs, 2022 The highly specific induction of RNA interference-mediated gene knockdown, based on the direct application of small interfering RNAs (siRNAs), opens novel avenues towards innovative therapies.
M. Friedrich, A. Aigner
semanticscholar +1 more source
Molecular Cell, 2004 An array of gene silencing pathways share a common early step: Dicer cleaves double-stranded RNA (dsRNA) into approximately 20-25 nucleotide fragments that direct the silencing machinery to specific targets. A recent report in Cell reveals how Dicer's two RNase III domains collaborate during dsRNA processing and sets the stage for a deeper ...
Erik J. Sontheimer, John W. Pham
openaire +3 more sources
Therapeutic siRNA: state of the art
Signal Transduction and Targeted Therapy, 2020 RNA interference (RNAi) is an ancient biological mechanism used to defend against external invasion. It theoretically can silence any disease-related genes in a sequence-specific manner, making small interfering RNA (siRNA) a promising therapeutic ...
Bo Hu +6 more
semanticscholar +1 more source
Functional siRNA Delivery by Extracellular Vesicle–Liposome Hybrid Nanoparticles
Advanced Healthcare Materials, 2021 The therapeutic use of RNA interference is limited by the inability of siRNA molecules to reach their site of action, the cytosol of target cells. Lipid nanoparticles, including liposomes, are commonly employed as siRNA carrier systems to overcome this ...
M. Evers +8 more
semanticscholar +1 more source
Targeted Delivery of siRNA [PDF]
BioMed Research International, 2006 Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier.
Oliveira, S. +2 more
openaire +5 more sources
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2013 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Ahmed +38 more
core +6 more sources
Beilstein Journal of Organic Chemistry, 2021 Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their
Christopher Liczner +4 more
doaj +1 more source