Results 211 to 220 of about 497,452 (342)

A novel pH-sensitive nanoparticles encapsulating anti-PD-1 antibody and MDK-siRNA overcome immune checkpoint blockade resistance in HCC via reshaping immunosuppressive TME. [PDF]

J Exp Clin Cancer Res
Xu H, Li S, Liu Y, Sung YY, Zhou Y, Wu H.   +5 more
europepmc   +1 more source

Knockdown of C‐terminal Src kinase by siRNA‐mediated RNA interference augments T cell receptor signaling in mature T cells [PDF]

, 2004
Torkel Vang, Hilde Abrahamsen, Sondre Myklebust, Jorrit M. Enserink, Hans Prydz, Tomas Mustelin, Mohammed Amarzguioui, Kjetil Taskén   +7 more
openalex   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Correction: Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway. [PDF]

J Orthop Surg Res
Luo Y, Zhou F, Wang X, Yang R, Li Y, Wu X, Ye B.   +6 more
europepmc   +1 more source

Transfection of human tumour cells with Mre11 siRNA and the increase in radiation sensitivity and the reduction in heat-induced radiosensitization [PDF]

, 2004
Mengchang Xu, Robert J. Myerson, Clayton R. Hunt, Sandeep Kumar, Eduardo G. Moros, W. Straube, Joseph L. Roti Roti   +6 more
openalex   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Inhibition of Talin2 dedifferentiates myofibroblasts and reverses lung and kidney fibrosis. [PDF]

Sci Rep
White MJV, Ozkan M, Medellin JEG, Solanki A, Hubbell JA.   +4 more
europepmc   +1 more source

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Two cancer cell lines utilize Myosin 10 and the kinesin HSET differentially to maintain mitotic spindle bipolarity. [PDF]

PLoS One
Yim YI, Wu X, Gasilina A, Hammer JA.
europepmc   +1 more source

A new vector, based on the PolII promoter for the U1 snRNA gene, for the expression of siRNAs in mammalian cells [PDF]

, 2004
Michela A. Denti
openalex   +1 more source