Results 221 to 230 of about 527,047 (339)

NIR-induced spatiotemporally controlled gene silencing by upconversion nanoparticle-based siRNA nanocarrier

, 2017
Guojun Chen, Ben Ma, Ruosen Xie, Yuyuan Wang, Kefeng Dou, Shaoqin Gong   +5 more
openalex   +2 more sources

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

C16-siRNAs in Focus: Development of ALN-APP, a Promising RNAi-Based Therapeutic for Alzheimer's Disease. [PDF]

Pharmaceuticals (Basel)
Titze-de-Almeida R, Oliveira Gomes GM, Santos TCD, Titze-de-Almeida SS.   +3 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

The Dawn of Precision Medicine in Pediatric Nephrology: Lumasiran and the Era of siRNA Therapies for Primary Hyperoxaluria Type 1. [PDF]

J Pers Med
Dotis J, Fourikou M.
europepmc   +1 more source

Complexationof siRNA with Galactose-FunctionalizedDendrimers: PAMAM vs PETIM

Tarun Maity (15384040), Yogendra Kumar (1393624), Prabal K. Maiti (818949)   +2 more
openalex   +1 more source

TARGETED DELIVERY OF siRNA TO CELL DEATH PROTEINS IN SEPSIS

, 2009
Pavan Brahmamdam, Eizo Watanabe, Jacqueline Unsinger, Katherine Chang, William Schierding, Andrew S. Hoekzema, Tony Zhou, Jacquelyn S. McDonough, Heather Holemon, Jeremy D. Heidel, Craig M. Coopersmith, Jonathan E. McDunn, Richard S. Hotchkiss   +12 more
openalex   +2 more sources

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Editorial Note: Expression of Concern: Chaperone-mediated autophagy targets IFNAR1 for lysosomal degradation in free fatty acid treated HCV cell culture. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

siRNA duplxes used in this study.

Jing Chen (4762), Lin han Zhong (22784203), Jin xia Chen (22784206), Hui xin Song (22784209), Lin ke Zou (22784212), Xiao qing Bi (22784215), Bing qian Zhao (22784218), Mei zhen Li (22784221), Kun Li (277035), Kang Wang (415359), Jia jun Yang (22784224), Jin Cui (638547), Li Wang (15202), Bin Zhou (84959)   +13 more
openalex   +1 more source