Results 21 to 30 of about 34,817 (248)
Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S]
Journal of Lipid Research, 2011 Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blocks ...
Brandon Ason +18 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2019 Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult.
Radu Mihaila +14 more
doaj +1 more source
Dendrimers for siRNA Delivery [PDF]
Pharmaceuticals, 2013 Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups.
Swati Biswas, Vladimir P. Torchilin
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Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing
Journal of Lipid Research, 2012 Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver ...
Samnang Tep +11 more
doaj +1 more source
Journal of Lipid Research, 2011 Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE–/– and low density lipoprotein receptor (LDLr)–/– mice have been extensively used for studies of coronary atherosclerosis.
Marija Tadin-Strapps +24 more
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Role of non-coding RNAs in Dengue virus-host interaction
Frontiers in Bioscience-Scholar, 2021 Dengue is potentially a life-threatening arthropod-borne viral infection for which there are no known therapeutic agents till date. Early stage diagnosis of dengue infection is still lacking.
Deeksha Madhry +8 more
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siRNA-optimized Modifications for Enhanced In Vivo Activity
Molecular Therapy: Nucleic Acids, 2012 Current modifications used in small interfering RNAs (siRNAs), such as 2’-methoxy (2’-OMe) and 2’-fluoro (2’-F), improve stability, specificity or immunogenic properties but do not improve potency.
Denise M Kenski +8 more
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Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA
Molecular Therapy: Nucleic Acids, 2017 Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary
Radu Mihaila +9 more
doaj +1 more source
Structure, 2004 AbstractA recent report (Ma et al., 2004) describes the crystal structure of a “mini-siRNA” bound to a PAZ domain.
openaire +2 more sources
Addis Ababa/Finfinee: A Blueprint towards Twin-city Administration
Ethiopian Journal of the Social Sciences and Humanities, 2018 This article analyses the challenge of Addis Ababa´s double status – both as capital of Ethiopia and that of the Regional State of Oromia. It delves into the unresolved issue of the special interest of Oromia in Addis Ababa/Finfinnee.
Zelalem T. Sirna
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