THE EFFECT OF SILENCING THE Tip60 GENE ON THE RESPONSE TO RADIOTHERAPY IN BREAST CANCER CELLS
Sabiad, 2022 One of the most important problems encountered in patients with triple-negative breast cancer (BC) treatment is the inadequate response of tumor tissue to treatment.
Ece Miser Salihoğlu +2 more
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Silencing of mTOR Facilitates the Cyclophosphamide-Mediated Cytotoxicity in Acute Lymphoblastic Leukemia [PDF]
ImmunoAnalysis, 2023 Background: Acute lymphoblastic leukemia (ALL) is a neoplastic disorder in which lymphoid progenitors of patients proliferate malignantly and accumulate in peripheral blood (PB), bone marrow (BM), and other sites.
Mohammad Sadeghi +6 more
doaj +1 more source
Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]
, 2007 The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li +4 more
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Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis [PDF]
, 2020 Strategies for controlled delivery of therapeutic siRNA into living cells are in high demand as endosomal escape remains the most prominent bottleneck at the intracellular level.
Barriga, Gerardo Garcia-Diaz +16 more
core +3 more sources
Bcl-2 Inhibition Induces a Synergistic Effect in Combination with Doxorubicin in Chronic Lymphocytic Leukemia [PDF]
ImmunoAnalysis, 2022 Background: Chronic lymphocytic leukemia (CLL), a common neoplastic disease, is associated with the accumulation of B-lymphocytes in the hematopoietic organs.
Mohammad Sadeghi +6 more
doaj +1 more source
Structure, 2004 AbstractA recent report (Ma et al., 2004) describes the crystal structure of a “mini-siRNA” bound to a PAZ domain.
openaire +2 more sources
Addis Ababa/Finfinee: A Blueprint towards Twin-city Administration
Ethiopian Journal of the Social Sciences and Humanities, 2018 This article analyses the challenge of Addis Ababa´s double status – both as capital of Ethiopia and that of the Regional State of Oromia. It delves into the unresolved issue of the special interest of Oromia in Addis Ababa/Finfinnee.
Zelalem T. Sirna
doaj +1 more source
B7-H7 Suppression Increases the Expression of CTLA-4 and VISTA Genes in Gastric Cancer Cell Line [PDF]
ImmunoAnalysis, 2022 Gastric cancer (GC) is a multifactorial genetic malignancy that tumor metastasis is one of the principal characteristics of this disease. The B7 family immune checkpoints have important functions in maintaining the immune system's equilibrium that ...
Nadia Bolandi +3 more
doaj +1 more source
An Inside Job for siRNAs [PDF]
Molecular Cell, 2008 Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously ...
Erik J. Sontheimer +2 more
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Design of Cationic Multi-Walled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradication [PDF]
, 2015 Polo-Like Kinase (PLK1) has been identified as a potential target in cancer gene therapy via chemical or genetic inhibitory approaches. The biomedical applications of chemically functionalized carbon nanotubes (f-CNTs) in cancer therapy have been studied
aaLanner J. T. +42 more
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