Results 21 to 30 of about 302,587 (323)
Pharmaceutics, 2020 Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of cancer metastasis.
Hisako Ibaraki +5 more
doaj +1 more source
Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems
Biomolecules, 2019 Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate ...
Shima Tavakol +13 more
doaj +1 more source
B7-H7 Suppression Increases the Expression of CTLA-4 and VISTA Genes in Gastric Cancer Cell Line [PDF]
ImmunoAnalysis, 2022 Gastric cancer (GC) is a multifactorial genetic malignancy that tumor metastasis is one of the principal characteristics of this disease. The B7 family immune checkpoints have important functions in maintaining the immune system's equilibrium that ...
Nadia Bolandi +3 more
doaj +1 more source
An Inside Job for siRNAs [PDF]
Molecular Cell, 2008 Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously ...
Erik J. Sontheimer +2 more
openaire +3 more sources
Silencing of mTOR Facilitates the Cyclophosphamide-Mediated Cytotoxicity in Acute Lymphoblastic Leukemia [PDF]
ImmunoAnalysis, 2023 Background: Acute lymphoblastic leukemia (ALL) is a neoplastic disorder in which lymphoid progenitors of patients proliferate malignantly and accumulate in peripheral blood (PB), bone marrow (BM), and other sites.
Mohammad Sadeghi +6 more
doaj +1 more source
OncoImmunology, 2018 TGFβ secreted by tumor cells and/or tumor infiltrating stromal cells is a key mediator of tumor growth and immune suppression at the tumor site. Nonetheless, clinical trials in cancer patients targeting the TGFβ pathway exhibited at best a modest ...
Yvonne Puplampu-Dove +5 more
doaj +1 more source
Bcl-2 Inhibition Induces a Synergistic Effect in Combination with Doxorubicin in Chronic Lymphocytic Leukemia [PDF]
ImmunoAnalysis, 2022 Background: Chronic lymphocytic leukemia (CLL), a common neoplastic disease, is associated with the accumulation of B-lymphocytes in the hematopoietic organs.
Mohammad Sadeghi +6 more
doaj +1 more source
RNA interference and Register Machines (extended abstract) [PDF]
EPTCS 100, 2012, pp. 107-112, 2012 RNA interference (RNAi) is a mechanism whereby small RNAs (siRNAs) directly control gene expression without assistance from proteins. This mechanism consists of interactions between RNAs and small RNAs both of which may be single or double stranded. The target of the mechanism is mRNA to be degraded or aberrated, while the initiator is double stranded ...
arxiv +1 more source
The OP Protein Cage: A Versatile Molecular Delivery Platform
CHIMIA, 2021 Well-defined containers constructed from multiple protein subunits are a unique class of nanomaterial useful in supramolecular chemistry and biology. These protein cages are widespread in nature, where they are responsible for a diversity of important ...
Thomas G.W. Edwardson +2 more
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Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy
Pharmaceutics, 2020 Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration.
Emanuela Fabiola Craparo +4 more
doaj +1 more source