Results 31 to 40 of about 302,587 (323)
Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown [PDF]
Scientific Reports 6, Article number: 30245 (2016), 2017 A tri-block nanoparticle (TBN) comprising of an enzymatically cleavable porous gelatin nanocore encapsulated with gefitinib (tyrosine kinase inhibitor (TKI)) and surface functionalized with cetuximab-siRNA conjugate has been synthesized. Targeted delivery of siRNA to undruggable KRAS mutated non-small cell lung cancer cells would sensitize the cells to
arxiv +1 more source
siRNA for Influenza Therapy [PDF]
Viruses, 2010 Influenza virus is one of the most prevalent and ancient infections in humans. About a fifth of world's population is infected by influenza virus annually, leading to high morbidity and mortality, particularly in infants, the elderly and the immunocompromised. In the US alone, influenza outbreaks lead to roughly 30,000 deaths each year.
openaire +4 more sources
Epigenetic regulation as a promising tool for treatment of atherosclerosis
Frontiers in Bioscience-Scholar, 2020 Atherosclerosis is one of the leading causes of death from cardiovascular disease (CVD) that primarily involves mid size and large arteries. Atherosclerosis is associated with disruption of lipid metabolism and chronic inflammatory processes.
Daria Skuratovskaia +4 more
doaj +1 more source
Advances of non-viral nanometer vectors delivery systemfor siRNA
生物医学转化, 2021 The delivery of small interfering RNA is now mainly through viral vector delivery, chemicalmodification delivery, microinjection delivery, and non-viral nanometer vector delivery.
Geng Xiang, Huang Meizhou, Li Jianyong
doaj +1 more source
Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparticles with Multifunctional Polymer Caps [PDF]
, 2015 A new general route for siRNA delivery is presented combining porous core-shell silica nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the internal storage and release of siRNA from mesoporous silica nanoparticles (MSN) with orthogonal core-shell surface chemistry was investigated as a function of pore-size, pore ...
arxiv +1 more source
MicroRNAs -- targeting and target prediction [PDF]
N Biotechnol. 2010 Jul 31;27(3):243-9, 2015 MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs.
arxiv +1 more source
TME-Responsive Multistage Nanoplatform for siRNA Delivery and Effective Cancer Therapy
International Journal of Nanomedicine, 2021 Shuwen Cao,1,2 Chunhao Lin,1,2 Xiuling Li,1,2 Yixia Liang,1,2 Phei Er Saw1,2 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ...
Cao S, Lin C, Li X, Liang Y, Saw PE
doaj
Translocation and encapsulation of siRNA inside carbon nanotubes [PDF]
, 2012 We report spontaneous translocation of small interfering RNA (siRNA) inside carbon nanotubes (CNTs) of various diameters and chirality using all atom molecular dynamics (MD) simulations with explicit solvent. We use Umbrella sampling method to calculate the free energy landscape of the siRNA entry and translocation event.
arxiv +1 more source
Using a hydrogen-bond index to predict the gene-silencing efficiency of siRNA based on the local structure of mRNA [PDF]
Biochem Biophys Res Comms, vol.320 (2) 622 (2004), 2017 The gene silencing effect of short interfering RNA (siRNA) is known to vary strongly with the targeted position of the mRNA. A number of hypotheses have been suggested to explain this phenomenon. We would like to test if this positional effect is mainly due to the secondary structure of the mRNA at the target site.
arxiv +1 more source
The Long and Short of siRNAs [PDF]
Molecular Cell, 2002 A recent work identifies a distinct class of siRNAs derived from transgenes and endogenous retroelements in plants (Hamilton et al., 2002). This class has slower electrophoretic mobility than previously characterized siRNAs and may play an important role in transgene-induced systemic silencing and in methylation of endogenous retroelement DNA.
openaire +3 more sources