Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA [PDF]
, 2019 Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra-
De Backer, Lynn +7 more
core +1 more source
Design of double-walled carbon nanotubes for biomedical applications [PDF]
, 2012 Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for
Coley, Helen M. +8 more
core +2 more sources
Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems
Biomolecules, 2019 Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate ...
Shima Tavakol +13 more
doaj +1 more source
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane [PDF]
, 2012 Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation.
Andrews +26 more
core +3 more sources
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging [PDF]
, 2006 Small interfering RNA (siRNA) molecules are potent effectors of post-transcriptional gene silencing. Using noninvasive bioluminescent imaging and a mathematical model of siRNA delivery and function, the effects of target-specific and treatment-specific ...
Bartlett, Derek W., Davis, Mark E.
core +1 more source
Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging [PDF]
, 2007 Targeted delivery represents a promising approach for the development of safer and more effective therapeutics for oncology applications. Although macromolecules accumulate nonspecifically in tumors through the enhanced permeability and retention (EPR ...
Bartlett, Derek W. +4 more
core +2 more sources
MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer. [PDF]
, 2015 Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic.
Amiji, Mansoor M +6 more
core +1 more source
Binding of small interfering RNA molecules is crucial for RNA interference suppressor activity of rice hoja blanca virus NS3 in plants [PDF]
, 2009 The NS3 protein of rice hoja blanca tenuivirus represents a viral suppressor of RNAi that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, an ...
Goldbach, R.W. +5 more
core +2 more sources
Exosomes are natural carriers of exogenous siRNA to human cells in vitro [PDF]
, 2013 © 2013 Shtam et al. Background: Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-to-cell communication including shuttle RNA, mainly mRNA and microRNA.
Filatov, MV +5 more
core +1 more source
Study of LBHD1 Expression with Invasion and Migration of Bladder Cancer
Open Life Sciences, 2019 LBHD1 (C11ORF48) is one of the ten potential tumor antigens identified by immunoscreening the urinary bladder cancer cDNA library in our previous study. We suspect that its expression is associated with human bladder cancer.
Dong Chunhui +4 more
doaj +1 more source