Results 31 to 40 of about 34,817 (248)
Beilstein Journal of Organic Chemistry, 2021 Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their
Christopher Liczner +4 more
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Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme [PDF]
Nanomedicine Journal, 2021 Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was studied on MCF-7/Sensitive and ...
Serap Yalcin, Ufuk Gündüz
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Vaccines, 2020 The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a ...
Simona Kranjc Brezar +5 more
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Silencing of mTOR Facilitates the Cyclophosphamide-Mediated Cytotoxicity in Acute Lymphoblastic Leukemia [PDF]
ImmunoAnalysis, 2023 Background: Acute lymphoblastic leukemia (ALL) is a neoplastic disorder in which lymphoid progenitors of patients proliferate malignantly and accumulate in peripheral blood (PB), bone marrow (BM), and other sites.
Mohammad Sadeghi +6 more
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An Inside Job for siRNAs [PDF]
Molecular Cell, 2008 Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously ...
Erik J. Sontheimer +2 more
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Bcl-2 Inhibition Induces a Synergistic Effect in Combination with Doxorubicin in Chronic Lymphocytic Leukemia [PDF]
ImmunoAnalysis, 2022 Background: Chronic lymphocytic leukemia (CLL), a common neoplastic disease, is associated with the accumulation of B-lymphocytes in the hematopoietic organs.
Mohammad Sadeghi +6 more
doaj +1 more source
Тонкие химические технологии, 2019 Research methods based on the use of RNA interference mechanisms are now included among the basic methods of molecular biology. Drugs based on siRNA are being developed for the treatment of cancer, infectious diseases and other pathologies that are ...
Z. G. Denieva +2 more
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B7-H7 Suppression Increases the Expression of CTLA-4 and VISTA Genes in Gastric Cancer Cell Line [PDF]
ImmunoAnalysis, 2022 Gastric cancer (GC) is a multifactorial genetic malignancy that tumor metastasis is one of the principal characteristics of this disease. The B7 family immune checkpoints have important functions in maintaining the immune system's equilibrium that ...
Nadia Bolandi +3 more
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Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ [PDF]
Exploration of Digital Health TechnologiesAim: Genetic instability represents the hallmark of carcinogenesis. For cancer, the retinoblastoma (RB) gene defect allowing genetic instability was successfully exploited to eliminate cancer.
Frank-Un Hong +2 more
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Pharmaceutics, 2020 Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of cancer metastasis.
Hisako Ibaraki +5 more
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