siRNA for Influenza Therapy [PDF]
Viruses, 2010 Influenza virus is one of the most prevalent and ancient infections in humans. About a fifth of world's population is infected by influenza virus annually, leading to high morbidity and mortality, particularly in infants, the elderly and the immunocompromised. In the US alone, influenza outbreaks lead to roughly 30,000 deaths each year.
openaire +4 more sources
Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity [PDF]
, 2008 Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of amines ...
Dehshahri, Ali +3 more
core +1 more source
TME-Responsive Multistage Nanoplatform for siRNA Delivery and Effective Cancer Therapy
International Journal of Nanomedicine, 2021 Shuwen Cao,1,2 Chunhao Lin,1,2 Xiuling Li,1,2 Yixia Liang,1,2 Phei Er Saw1,2 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ...
Cao S, Lin C, Li X, Liang Y, Saw PE
doaj
The OP Protein Cage: A Versatile Molecular Delivery Platform
CHIMIA, 2021 Well-defined containers constructed from multiple protein subunits are a unique class of nanomaterial useful in supramolecular chemistry and biology. These protein cages are widespread in nature, where they are responsible for a diversity of important ...
Thomas G.W. Edwardson +2 more
doaj +1 more source
Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles [PDF]
, 2008 Short interfering RNA (siRNA) attracts much attention for the treatment of various diseases. However, its delivery, especially via systemic routes, remains a challenge. Indeed, naked siRNAs are rapidly degraded, while complexed siRNAs massively aggregate
De Smedt, Stefaan +4 more
core +1 more source
Silencing E3 Ubiqutin ligase ITCH as a potential therapy to enhance chemotherapy efficacy in p53 mutant neuroblastoma cells [PDF]
, 2020 P53 mutations are responsible for drug-resistance of tumour cells which impacts on the efficacy of treatment. Alternative tumour suppressor pathways need to be explored to treat p53- deficient tumours.
Hart, Stephen L +2 more
core +2 more sources
Epigenetic regulation as a promising tool for treatment of atherosclerosis
Frontiers in Bioscience-Scholar, 2020 Atherosclerosis is one of the leading causes of death from cardiovascular disease (CVD) that primarily involves mid size and large arteries. Atherosclerosis is associated with disruption of lipid metabolism and chronic inflammatory processes.
Daria Skuratovskaia +4 more
doaj +1 more source
The Long and Short of siRNAs [PDF]
Molecular Cell, 2002 A recent work identifies a distinct class of siRNAs derived from transgenes and endogenous retroelements in plants (Hamilton et al., 2002). This class has slower electrophoretic mobility than previously characterized siRNAs and may play an important role in transgene-induced systemic silencing and in methylation of endogenous retroelement DNA.
openaire +3 more sources
Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy
Pharmaceutics, 2020 Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration.
Emanuela Fabiola Craparo +4 more
doaj +1 more source
PENGENDALIAN PERILAKU MENYIMPANG SISWA DILIHAT DARI PERAN ORANG TUA DAN GURU DI SMP ISLAM AL-ISTIQOMAH DEPOK [PDF]
, 2017 Beragamnya perilaku menyimpang yang dilakukan siswa di sekolah, menjadi perhatian khusus bagi guru sebagai agen penting yang bertanggung jawab menangani permasalahan ini di sekolah. Semua itu tidak akan berjalan sesuai dengan yang diharapkan tanpa adanya
Fitakila, Sirna
core