Results 71 to 80 of about 302,587 (323)
Cancer Management and Research, 2021 Xiao-Hong Chen,1 Ding-Li Yu,2 Jiang-Tao Zhong,2 Shui-Hong Zhou,2 Jun Fan,3 Zhong-Jie Lu4 1Department of Otolaryngology, The Second Hospital of Jiaxing (The Second Affiliated Hospital, Jiaxing University), Jiaxing City, Zhejiang Province, 314000, People’s
Chen XH +5 more
doaj
Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition
Molecular Therapy - Nucleic Acids, 2012 Oligonucleotide aptamer-mediated in vivo cell targeting of small interfering RNAs (siRNAs) is emerging as a useful approach to enhance the efficacy and reduce the adverse effects resulting from siRNA-mediated genetic interference. A current main impediment in aptamer-mediated siRNA targeting is that the activity of the siRNA is often compromised when ...
Marcio C. Bajgelman +4 more
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FEBS Open Bio, EarlyView.FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley +1 more source
The EuroBiotech Journal, 2019 The Prion Protein (PrP) is mostly known for its role in prion diseases, where its misfolding and aggregation can cause fatal neurodegenerative conditions such as the bovine spongiform encephalopathy and human Creutzfeldt–Jakob disease.
De Riccardis Lidia +8 more
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Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems
KONA Powder and Particle Journal, 2015 This article reviews the pulmonary route of administration, aerosol delivery devices, characterization of pulmonary drug delivery systems, and discusses the rationale for inhaled delivery of siRNA.
Susanne R. Youngren-Ortiz +3 more
doaj +1 more source
Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles [PDF]
Integrative Biology, 2012 One important barrier facing the delivery of short interfering RNAs (siRNAs) via synthetic nanoparticles is the rate of nanoparticle disassembly. However, our ability to optimize the release kinetics of siRNAs from nanoparticles for maximum efficacy is limited by the lack of methods to track their intracellular disassembly.
Alabi, Christopher A. +3 more
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Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
In silico evidence of the relationship between miRNAs and siRNAs [PDF]
arXiv, 2007 Both short interfering RNAs (siRNAs) and microRNAs (miRNAs) mediate the repression of specific sequences of mRNA through the RNA interference pathway. In the last years several experiments have supported the hypothesis that siRNAs and miRNAs may be functionally interchangeable, at least in cultured cells.
arxiv
Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
wiley +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source