Results 111 to 120 of about 100,955 (193)

Characterization of Sirt2 using conditional RNAi in mice [PDF]

, 2011
Within the past eight years, RNA interference (RNAi) has emerged as a powerful experimental tool for gene function analysis in mice. Reversible control of shRNA mediated RNAi has been achieved by using a tetracycline (tet)-inducible promoter.
Reiss, Martina
core  

Representation of probabilistic scientific knowledge [PDF]

, 2013
This article is available through the Brunel Open Access Publishing Fund. Copyright © 2013 Soldatova et al; licensee BioMed Central Ltd.The theory of probability is widely used in biomedical research for data analysis and modelling.
De Grave, K, King, RD, Rzhetsky, A, Soldatova, LN   +3 more
core   +1 more source

Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes

Romanian Journal of Internal Medicine, 2019
Introduction. Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify the level of inflammatory biomarkers.
Savchenko Liudmyla G., Digtiar Nataliia I., Selikhova Liudmyla G., Kaidasheva Elvira I., Shlykova Oksana A., Vesnina Liudmyla E., Kaidashev Igor P.   +6 more
doaj   +1 more source

Autophagy in DNA Damage Response [PDF]

, 2015
DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska, Janusz Blasiak, Jolanta Bialkowska-Warzecha, Kai Kaarniranta, Piotr Czarny   +4 more
core   +2 more sources

Sparse whole-genome sequencing identifies two loci for major depressive disorder. [PDF]

, 2015
Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis.
CONVERGE consortium
core   +1 more source

NAD-Dependent Protein Deacetylase Sirtuin-1 Mediated Mitophagy Regulates Early Brain Injury After Subarachnoid Hemorrhage

Journal of Inflammation Research
Gen Wang, Ning Lin Department of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), Chuzhou, Anhui Province, People’s Republic of ChinaCorrespondence: Ning Lin, Email lin_neurosurgery@163 ...
Wang G, Lin N
doaj  

Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma

Cancer Biology & Therapy
We aimed to evaluate the influence of sirtuin1 (sirt1) on the ESCC chemotherapeutic sensitivity to cisplatin. We used ESCC cell ablation sirt1 for establishing a xenograft mouse tumor model. The tumor volume was then detected.
Xuewen Yang, Shisen Li, Chunsheng Xu, Shushang Liu, Xiang Zhang, Bo Lian, Mengbin Li   +6 more
doaj   +1 more source

Mechanism study on the attenuation of cerebral ischemia–reperfusion injury by LBP extract through regulation of SIRT1/PGC-1α axis

Translational Neuroscience
This study aims to determine if Lycium barbarum polysaccharides (LBP) extract attenuate oxidative stress by regulating the SIRT1/PGC-1α axis, potentially ameliorating oxygen–glucose deprivation/reperfusion (OGD/R)-induced neuronal damage.
Niu Qingfeng, Peng Jiahui, Zhou Yujia, Li Xiaowen, Liu Ouya, Xin Cheng, Liu Ping, Hei Changchun, Yang Xiao   +8 more
doaj   +1 more source

SIRT1 Gene [PDF]

, 2020
openaire   +1 more source

The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control [PDF]

, 2016
Imai, Shin-ichiro
core   +2 more sources