Results 11 to 20 of about 100,955 (193)
Molecular Cell, 2008 In a recent issue of Cell Host & Microbe, Kwon et al. (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation.
Blazek, Dalibor, Peterlin, B. Matija
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Rejuvenating SIRT1 Activators [PDF]
Cell Metabolism, 2013 Whether the red wine component resveratrol directly activates the NAD(+)-dependent protein deacetylase SIRT1 has been debated. A recent study by Hubbard et al. (2013) strengthens the case that SIRT1-activating compounds (STACs) function as positive allosteric regulators of SIRT1 and thereby regulate mitochondrial function.
Gut, Philipp, Verdin, Eric
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SIRT1 and Kidney Function [PDF]
Kidney Diseases, 2015 <b><i>Background:</i></b> SIRT1 is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases. Abundantly expressed in the kidney, especially in the renal medulla, SIRT1 is closely involved in renal physiology and pathology.
Yi, Guan, Chuan-Ming, Hao
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MiR-138 promotes apoptosis of colon cancer cells by targeting SIRT1
Di-san junyi daxue xuebao, 2021 Objective To investigate the mechanism of miR-138 involving in the apoptosis of colon cancer cells by regulating SIRT1. Methods RT-qPCR was used to detect the expression of miR-138 in colon cancer cell lines HCT 116, SW480, Caco-2, HT29 and SW1116.
YANG Yang, PENG Wenli
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Vinca herbacea Extract Suppresses NF-kB Signaling and Modulates SIRT1/AMPK/PGC1α Axis to Exert Antidiabetic Effects in Streptozotocin- Induced Diabetic Rats [PDF]
Research Journal of Pharmacognosy, 2022 Background and Objectives: AMPK/SIRT1/PGC1α signaling pathway has an important role in diabetic condition. Some natural products exert anti-diabetic effects by modulating this pathway and also by inhibition of NF-κB. Vinca herbacea has potent antioxidant
Nasim Abedimanesh +13 more
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Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy [PDF]
Cell Death & Disease, 2021 AbstractMounting studies have substantiated that abrogating autophagy contributes to cardiac hypertrophy (CH). Sirtuin 1 (SIRT1) has been reported to support autophagy and inhibit CH. However, the upstream regulation mechanism behind the regulation of SIRT1 level in CH remains unclear.
Weichen Wang +6 more
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MiR-217 inhibition relieves oxidative stress-induced melanocyte damage by targeting sirtuin 1
Biotechnology & Biotechnological Equipment, 2020 Vitiligo is caused by the disappearance of melanocyte function in the skin, but the mechanism has not been fully elucidated. This study aimed to investigate the expression and role of miR-217 in dysfunctional human primary melanocytes caused by oxidative
Bo Huang, Xuecheng Sun, Aie Xu
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SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice [PDF]
, 2015 Huntingtons disease (HD) is a neurodegenerative disorder for which there are no disease-modifying treatments. SIRT1 is a NAD+-dependent protein deacetylase that is implicated in maintaining neuronal health during development, differentiation and ageing ...
Bates, GP +6 more
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Autoimmunity, 2021 Background Recent studies have provided strong evidence that lncRNAs play a functional regulatory role in diabetic retinopathy (DR). The purpose of this study was to investigate the effect of long non-coding RNA (lncRNA) X-inactive specific transcript ...
Jiayu Zhang +5 more
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Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]
, 2013 The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
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