Results 31 to 40 of about 100,955 (193)

Sirt1 in cerebral ischemia [PDF]

Brain Circulation, 2015
Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment of cerebral ischemia, mostly stroke and cardiac arrest, is limited and new neuroprotective therapies are
Kevin B Koronowski, Miguel A Perez-Pinzon   +1 more
openaire   +3 more sources

CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1 [PDF]

, 2018
Macroautophagy/autophagy is an important intracellular mechanism for the maintenance of cellular homeostasis. Here we show that the CERKL (ceramide kinase like) gene, a retinal degeneration (RD) pathogenic gene, plays a critical role in regulating ...
Danna Jia, Fei Liu, Haibo Jia, James Reilly, Jingyu Liu, Jingzhen Li, Mugen Liu, Qing Wang, Shanshan Han, Shanshan Yu, Tao Jiang, Tuson M, Vekslin S, Xiliang Liu, Xinhua Shu, Xuebin Hu, Yayun Qin, Yuexia Lv, Yuwen Huang, Zhaohui Tang, Zhaojing Lu, Zhen Qu   +21 more
core   +2 more sources

Role of forkhead box protein O1 and insulin on cell proliferation mediated by sirtuin 1 in goose primary hepatocytes

Journal of Applied Poultry Research, 2021
Summary: To explore the role of insulin and forkhead box protein O1 (FoxO1) on cell proliferation regulated by sirtuin 1 (Sirt1) in goose primary hepatocyte, goose primary hepatocytes were isolated and incubated with Sirt1 inhibitor and nicotinamide, and
Rongxue Wei, Chunchun Han, Fang He, Xiangping Xiong, Fengjiang Ye, Hehe Liu, Liang Li, Hongyong Xu, Shouhai Wei, Xianyin Zeng   +9 more
doaj   +1 more source

AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator [PDF]

Molecular Cell, 2007
SIRT1 is a protein deacetylase that regulates cellular responses to a variety of stresses. In a recent issue of Molecular Cell, Kim et al. (2007) report the identification of a cellular protein, AROS, that activates the SIRT1-mediated deacetylation of p53.
openaire   +2 more sources

Vascular smooth muscle Sirtuin-1 protects against aortic dissection during Angiotensin II-induced hypertension [PDF]

, 2015
BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not ...
Akiki, Rachid, Bachschmid, Markus, Cohen, Richard A., Fry, Jessica L., Gao, Yuan Z., Morgan, Kathleen G., Seta, Francesca, Shiraishi, Yasunaga, Turcotte, Raphaël, Yu, Xunjie, Zhang, Yanhang   +10 more
core   +1 more source

Artesunate reduces sepsis-mediated acute lung injury in a SIRT1-dependent manner [PDF]

BioImpacts, 2023
Introduction: Sepsis-mediated acute lung injury (ALI) is a critical clinical condition. Artesunate (AS) is a sesquiterpene lactone endoperoxide that was discovered in Artemisia annua, which is a traditional Chinese herb.
Zhaohui Liu, Yanli Meng, Yu Miao, Lili Yu, Qiannan Yu   +4 more
doaj   +1 more source

Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells. [PDF]

, 2015
Sirtuin (Sirt) 1 and Sirt 3 are nicotinamide adenine dinucleotide ((+))-dependent protein deacetylases that are important to a number of mitochondrial-related functions; thus, identification of sirtuin activators is important. Herein, we hypothesize that
Arguelles, Andrix, Bedi, Yudhishtar Singh, Chau, Jason, Choudhury, Mahua, Meruvu, Sunitha, Rucker, Robert, Zhang, Jian   +6 more
core   +1 more source

Evaluation of potential gene expression as early markers of insulin resistance and non-alcoholic fatty liver disease in the Indonesian population

Indonesian Journal of Biotechnology, 2018
Early detection of insulin resistance (IR) or non-alcoholic fatty liver disease (NAFLD) is crucial to prevent future risk of developing chronic diseases. Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Liver Fat Score (LFS), and Fatty Liver
Eunice Limantara, Felicia Kartawidjajaputra, Antonius Suwanto   +2 more
doaj   +1 more source

SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation

Stem Cell Research, 2020
SIRT1 (NAD+-dependent deacetylase) plays a suppressive role during the late stages of adipogenesis. However, the effects of SIRT1 on the early phases of adipogenic differentiation from embryonic stem cells (ESCs) are poorly understood. We employed Sirt1+/
Yu Jin Jung, Woong Park, Jeong Mi Noh, Kyung Pyo Kang, Tung Nguyen-Thanh, Myung Kwan Han, Won Kim   +6 more
doaj   +1 more source

SIRT1-mediated acute cardioprotection

American Journal of Physiology-Heart and Circulatory Physiology, 2011
Overexpression studies have revealed a role for silent information regulator of transcription 1 (SIRT1) lysine deacetylase in cardioprotection against ischemia-reperfusion injury via long-term transcriptional effects. However, short-term SIRT1-mediated lysine deacetylation, within the context of acute cardioprotection, is poorly understood.
Sergiy M, Nadtochiy, Hongwei, Yao, Michael W, McBurney, Wei, Gu, Leonard, Guarente, Irfan, Rahman, Paul S, Brookes   +6 more
openaire   +3 more sources