NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH
Cuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are lipoamidases that
Yingying Zhang +9 more
doaj +1 more source
The Yin-Yang balance of SIRT1 and SIRT2 in cancer metabolic remodeling. [PDF]
Yi F +13 more
europepmc +1 more source
SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling. [PDF]
Hamaidi I +20 more
europepmc +1 more source
miR-4687-5p promotes the progression of diabetic retinopathy by targeting SIRT2 to mediate inflammatory responses. [PDF]
Zhang Y, Liu S, Wei L, Cui Y.
europepmc +1 more source
SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells. [PDF]
Patra M +5 more
europepmc +1 more source
MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling. [PDF]
Sesay F +14 more
europepmc +1 more source
Effects of Chemical Modulators on Enzyme Specificity. [PDF]
Hecht AD, Igoshin OA.
europepmc +1 more source
SIRT2 Regulates EX VIVO PBMC Adhesion in Septic Shock Patients. [PDF]
Shrestha D +12 more
europepmc +1 more source

