Results 41 to 50 of about 8,557 (169)
ACS Chemical Biology, 2019 Small molecule inhibitors for SIRT2, a member of the sirtuin family of nicotinamide adenine dinucleotide-dependent protein lysine deacylases, have shown promise in treating cancer and neurodegenerative diseases. Developing SIRT2-selective inhibitors with better pharmacological properties is key to further realize the therapeutic potential of targeting ...
Jun Young Hong +3 more
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Knockout of Sirt2 alleviates traumatic brain injury in mice
Neural Regeneration Research, 2023 Sirtuin 2 (SIRT2) inhibition or Sirt2 knockout in animal models protects against the development of neurodegenerative diseases and cerebral ischemia. However, the role of SIRT2 in traumatic brain injury (TBI) remains unclear. In this study, we found that
Wei Wang +7 more
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The Journal of Cell Biology, 2008 Recent work from [Pandithage et al.][1] reveals a new pathway for controlling cell movement that involves a cancer enabler and a member of a protein family best known for boosting longevity. The researchers chanced on the discovery while investigating the oncogene Myc, which is overactive in ...
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The histone deacetylase SIRT2 stabilizes Myc oncoproteins [PDF]
Cell Death & Differentiation, 2012 Myc oncoproteins are commonly upregulated in human cancers of different organ origins, stabilized by Aurora A, degraded through ubiquitin-proteasome pathway-mediated proteolysis, and exert oncogenic effects by modulating gene and protein expression. Histone deacetylases are emerging as targets for cancer therapy. Here we demonstrated that the class III
Liu, PY +23 more
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The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer
Cell Reports, 2016 Summary: Overabundance of Slug protein is common in human cancer and represents an important determinant underlying the aggressiveness of basal-like breast cancer (BLBC).
Wenhui Zhou +6 more
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SIRT2 promotes murine melanoma progression through natural killer cell inhibition
Scientific Reports, 2021 SIRT2, an NAD+-dependent histone deacetylase, has been shown to play a pivotal role in various physiological processes, however, its role in cancer is currently controversial.
Manchao Zhang +8 more
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SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.
PLoS ONE, 2018 The NAD+-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific tissues is difficult since even physiological effects at the ...
Louise Lantier +7 more
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Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
PLoS Pathogens, 2018 Salmonella being a successful pathogen, employs a plethora of immune evasion mechanisms. This contributes to pathogenesis, persistence and also limits the efficacy of available treatment.
Mayuri Gogoi +5 more
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Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source