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Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes [PDF]
International Journal of Molecular Sciences, 2023 Type 2 diabetes (T2D) affects a large part of the adult population and impairs its quality of life. Because of this, natural compounds with antioxidant, anti-inflammatory and hypoglycemic properties have been used as adjuvants.
Beatriz Isabel García-Martínez +4 more
semanticscholar +2 more sources
Human Sirtuin Regulators: The “Success” Stories
Frontiers in Physiology, 2021 The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl modifications from lysine residues in various cellular targets including histones, transcription factors, and metabolic enzymes. Through these far-reaching activities,
Alyson M. Curry +4 more
doaj +2 more sources
The sirtuin family in health and disease
Signal Transduction and Targeted Therapy, 2022 Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes.
exaly +2 more sources
Sirtuin Modulators in Cellular and Animal Models of Human Diseases
Frontiers in Pharmacology, 2021 Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell ...
Jun Young Hong, Hening Lin, Hening Lin
doaj +2 more sources
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Nature Reviews Molecular Cell Biology, 2016 Michael S Bonkowski, David A Sinclair
exaly +2 more sources
Usnic acid reduces colon cancer cell viability and colony formation by aff ecting cancer cell metabolism [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Today, some natural and plant-based products are of great interest, at least as supplements, in cancer prevention and treatment due to their anti-cancer properties.
Turgut ANUK +7 more
doaj +1 more source
Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function
Frontiers in Cell and Developmental Biology, 2021 Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki +4 more
doaj +1 more source
Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice
European Heart Journal, 2023 Aims The mechanisms underlying ageing-induced vascular remodelling remain unclear. This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase sirtuin 2 (SIRT2) in ageing-induced vascular remodelling.
Y. Zhang +15 more
semanticscholar +1 more source
The Role of Sirtuin 1 (SIRT1) in Neurodegeneration
Cureus, 2023 Sirtuins (SIRT) are a class of histone deacetylases that regulate important metabolic pathways and play a role in several disease processes. Of the seven mammalian homologs currently identified, sirtuin 1 (SIRT1) is the best understood and most studied ...
Daniel I Razick +9 more
semanticscholar +1 more source
Biomedicines, 2022 Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders.
Sanghyun Kim +13 more
doaj +1 more source