Results 1 to 10 of about 70,767 (359)

The Clinical Role of SIRT-3 in the Acute Rejection Process of Kidney Transplantation and Its Effects on Graft Outcomes: Evaluation of Biomarker Potential [PDF]

Medicina
Background and Objectives: The aim of this study was to investigate the changes in the SIRT family, the effects of sirtuins on kidney graft function, and their potential as biomarkers in patients who develop rejection after kidney transplantation ...
Necip Altundaş, Eda Balkan, Murat Kizilkaya, Murat Altunok, Elif Demirci, Nurhak Aksungur, Salih Kara, Gürkan Öztürk, Abdullah Uyanik   +8 more
doaj   +2 more sources

Usnic acid reduces colon cancer cell viability and colony formation by aff ecting cancer cell metabolism [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
Today, some natural and plant-based products are of great interest, at least as supplements, in cancer prevention and treatment due to their anti-cancer properties.
Turgut ANUK, Barış YILDIZ, Ramazan DEMİREL, Meryem İÇEN, Selma YILDIRIM, Hatice BEŞEREN, Baycan MOR, Özkan ÖZDEN   +7 more
doaj   +1 more source

Human Sirtuin Regulators: The “Success” Stories

Frontiers in Physiology, 2021
The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl modifications from lysine residues in various cellular targets including histones, transcription factors, and metabolic enzymes. Through these far-reaching activities,
Alyson M. Curry, Dawanna S. White, Dickson Donu, Yana Cen, Yana Cen   +4 more
doaj   +1 more source

Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function

Frontiers in Cell and Developmental Biology, 2021
Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki, Garrison Komaniecki, Hening Lin, Hening Lin, Hening Lin   +4 more
doaj   +1 more source

Sirtuin 7 Inhibitor Attenuates Colonic Mucosal Immune Activation in Mice—Potential Therapeutic Target in Inflammatory Bowel Disease

Biomedicines, 2022
Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders.
Sanghyun Kim, Junhyoung Byun, Semyung Jung, Byoungjae Kim, Kangwon Lee, Hanjo Jeon, Jaemin Lee, Hyuksoon Choi, Eunsun Kim, Yoontae Jeen, Hongsik Lee, Hoonjai Chun, Bora Keum, Taehoon Kim   +13 more
doaj   +1 more source

BZD9L1 Differentially Regulates Sirtuins in Liver-Derived Cells by Inducing Reactive Oxygen Species

Biomedicines, 2023
Growing evidence has highlighted that mitochondrial dysfunction contributes to drug-induced toxicities and leads to drug attrition and post-market withdrawals.
Yeuan Ting Lee, Yi Jer Tan, Chern Ein Oon   +2 more
doaj   +1 more source

Reverse Electron Transport at Mitochondrial Complex I in Ischemic Stroke, Aging, and Age-Related Diseases

Antioxidants, 2023
Stroke is one of the leading causes of morbidity and mortality worldwide. A main cause of brain damage by stroke is ischemia-reperfusion (IR) injury due to the increased production of reactive oxygen species (ROS) and energy failure caused by changes in ...
Vishal Chavda, Bingwei Lu
doaj   +1 more source

The Emerging Role of SIRT7 in Glucose and Lipid Metabolism

Cells, 2023
Sirtuins (SIRT1–7 in mammals) are a family of NAD+-dependent lysine deacetylases and deacylases that regulate diverse biological processes, including metabolism, stress responses, and aging.
Kazuya Yamagata, Tomoya Mizumoto, Tatsuya Yoshizawa   +2 more
doaj   +1 more source

The Pathogenic Yeast Candida parapsilosis Forms Pseudohyphae through Different Signaling Pathways Depending on the Available Carbon Source

mSphere, 2022
Candida parapsilosis is an emerging fungal pathogen that primarily affects immunocompromised patients in hospitals. A significant risk factor is the use of implanted medical devices, which support the growth of biofilms composed of a mixture of ...
Christopher B. Rupert, Laura N. Rusche
doaj   +1 more source

DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

eLife, 2021
In eukaryotes, paused replication forks are prone to collapse, which leads to genomic instability, a hallmark of cancer. Dbf4-dependent kinase (DDK)/Hsk1Cdc7 is a conserved replication initiator kinase with conflicting roles in replication stress ...
Shalini Aricthota, Devyani Haldar
doaj   +1 more source