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Sirtuins, bioageing, and cancer [PDF]
Journal of Aging Research, 2011 The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins
McCaul, J. +3 more
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Usnic acid reduces colon cancer cell viability and colony formation by aff ecting cancer cell metabolism [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Today, some natural and plant-based products are of great interest, at least as supplements, in cancer prevention and treatment due to their anti-cancer properties.
Turgut ANUK +7 more
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Human Sirtuin Regulators: The “Success” Stories
Frontiers in Physiology, 2021 The human sirtuins are a group of NAD+-dependent protein deacylases. They “erase” acyl modifications from lysine residues in various cellular targets including histones, transcription factors, and metabolic enzymes. Through these far-reaching activities,
Alyson M. Curry +4 more
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Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function
Frontiers in Cell and Developmental Biology, 2021 Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki +4 more
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Mitochondrial Sirtuins in Reproduction [PDF]
Antioxidants, 2021 Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions contribute to altering the redox balance and predispose to aging and metabolic alterations. The sirtuin family is composed of seven members and three of them, SIRT3-5, are housed in mitochondria.
Di Emidio, Giovanna +5 more
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Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors [PDF]
International Journal of Molecular Sciences, 2021 Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells.
Nina Schmid +7 more
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Biomedicines, 2022 Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders.
Sanghyun Kim +13 more
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BZD9L1 Differentially Regulates Sirtuins in Liver-Derived Cells by Inducing Reactive Oxygen Species
Biomedicines, 2023 Growing evidence has highlighted that mitochondrial dysfunction contributes to drug-induced toxicities and leads to drug attrition and post-market withdrawals.
Yeuan Ting Lee +2 more
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Antioxidants, 2023 Stroke is one of the leading causes of morbidity and mortality worldwide. A main cause of brain damage by stroke is ischemia-reperfusion (IR) injury due to the increased production of reactive oxygen species (ROS) and energy failure caused by changes in ...
Vishal Chavda, Bingwei Lu
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The Emerging Role of SIRT7 in Glucose and Lipid Metabolism
Cells, 2023 Sirtuins (SIRT1–7 in mammals) are a family of NAD+-dependent lysine deacetylases and deacylases that regulate diverse biological processes, including metabolism, stress responses, and aging.
Kazuya Yamagata +2 more
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