Results 141 to 150 of about 74,229 (355)
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
A Selective Cyclic Peptidic Human SIRT5 Inhibitor
Molecules, 2016 In the current study, we discovered that a side chain-to-side chain cyclic pentapeptide harboring a central Nε-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1/2/3/6) inhibitor against human SIRT5-catalyzed ...
Jiajia Liu, Yajun Huang, Weiping Zheng
doaj +1 more source
Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16 [PDF]
, 2010 It is well understood that sir2 (sirtuin), an NAD-dependent deacetylase, is essential for the extension of lifespan under caloric restriction. However, the mechanism underlying activation of sir2 is unclear.
Hashimoto Teppei +4 more
core +1 more source
Telomeres and sirtuins: at the end we meet again [PDF]
, 2019 H. Amano, Ergün Sahin
openalex +1 more source
Clock gene dysregulation in epilepsy: A systematic review
Epilepsia Open, EarlyView.Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos +3 more
wiley +1 more source
Data in Brief, 2015 Expression of genes associated with inflammation was analyzed during differentiation of human pluripotent stem cells (PSCs) to hepatic cells. Messenger RNA transcript profiles of differentiated endoderm (day 5), hepatoblast (day 15) and hepatocyte-like ...
Joseph Ignatius Irudayam +10 more
doaj +1 more source
The Role of Increased Expression of Sirtuin 6 in the Prevention of Premature Aging Pathomechanisms [PDF]
, 2023 Adrianna Dzidek +4 more
openalex +1 more source
Tocotrienols: A Review From Source to Therapeutic Applications
Food Frontiers, EarlyView.Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño +6 more
wiley +1 more source
Sirtuins and calorie restriction [PDF]
Nature Reviews Molecular Cell Biology, 2012 Studies in mice have indicated that sirtuins do have a role in mediating the effects of CR.
openaire +2 more sources
Food Frontiers, EarlyView.Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li +8 more
wiley +1 more source