Results 181 to 190 of about 87,529 (407)

Nutrition, sirtuins and aging [PDF]

Genes & Nutrition, 2006
Beyond our inherited genetic make-up environmental factors are central for health and disease and finally determine our life span. Amongst the environmental factors nutrition plays a prominent role in affecting a variety of degenerative processes that are linked to aging.
openaire   +2 more sources

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16 [PDF]

, 2010
It is well understood that sir2 (sirtuin), an NAD-dependent deacetylase, is essential for the extension of lifespan under caloric restriction. However, the mechanism underlying activation of sir2 is unclear.
Hashimoto Teppei, Horikawa Makoto, Nomura Toshihisa, Sakamoto Kazuichi, 坂本 和一   +4 more
core   +1 more source

Maintenance of Carnitine Homeostasis as a Therapeutic Strategy to Attenuate Cisplatin‐Induced Acute Kidney Injury

Food Frontiers, EarlyView.
ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an Wu   +5 more
wiley   +1 more source

A Selective Cyclic Peptidic Human SIRT5 Inhibitor

Molecules, 2016
In the current study, we discovered that a side chain-to-side chain cyclic pentapeptide harboring a central Nε-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1/2/3/6) inhibitor against human SIRT5-catalyzed ...
Jiajia Liu, Yajun Huang, Weiping Zheng
doaj   +1 more source

Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives

Scientific Reports, 2019
Mammalian Sirtuin 6 (Sirt6) is an NAD+-dependent protein deacylase regulating metabolism and chromatin homeostasis. Sirt6 activation protects against metabolic and aging-related diseases, and Sirt6 inhibition is considered a cancer therapy.
W. You, Wei Zheng, S. Weiss, Katrin F. Chua, C. Steegborn   +4 more
semanticscholar   +1 more source

Profile of Inflammation-associated genes during Hepatic Differentiation of Human Pluripotent Stem Cells

Data in Brief, 2015
Expression of genes associated with inflammation was analyzed during differentiation of human pluripotent stem cells (PSCs) to hepatic cells. Messenger RNA transcript profiles of differentiated endoderm (day 5), hepatoblast (day 15) and hepatocyte-like ...
Joseph Ignatius Irudayam, Deisy Contreras, Lindsay Spurka, Songyang Ren, Vidhya Kanagavel, Arunachalam Ramaiah, Alagappan Annamalai, Samuel W. French, Andrew S. Klein, Vincent Funari, Vaithilingaraja Arumugaswami   +10 more
doaj   +1 more source

Sirtuins and the hepatic regulation of energy homeostasis # [PDF]

, 2009
Puneet Puri, Arun J. Sanyal
openalex   +1 more source

Sirtuins and calorie restriction [PDF]

Nature Reviews Molecular Cell Biology, 2012
Studies in mice have indicated that sirtuins do have a role in mediating the effects of CR.
openaire   +2 more sources

Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis

, 2020
Yuanqi Yang, Chuan Liu, Jie Yang, Fangzhengyuan Yuan, Ran Cheng, Renzheng Chen, Yang Shen, Lan Huang   +7 more
openalex   +1 more source

SIRTUIN 1 PLAYS A CRUCIAL ROLE IN MODULATING THE PULMONARY AND SYSTEMIC HYPOXIC RESPONSE IN MICE: NOVEL ROLE FOR HYPOXIA INDUCIBLE FACTOR-3ALPHA? [PDF]

, 2014
Mohamad Taha, Yingjie Deng, Michael W. McBurney, D.J. Stewart   +3 more
openalex   +1 more source