Results 181 to 190 of about 84,834 (402)
Sirtuins: a conserved key unlocking AceCS activity [PDF]
, 2006 Brian J. North, David Sinclair
openalex +1 more source
USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Osimertinib (OSI) resistance in non‐small cell lung cancer (NSCLC) remains a significant challenge. This report explored the precise role of USP28 on OSI resistance in NSCLC and identified a functional downstream effector. OSI‐resistant H1975 cells (H1975/OSI) were established by long‐term OSI exposure.
Hu‐Sen Fan +4 more
wiley +1 more source
Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance
Antioxidants, 2018 Hydrogen sulfide (H2S) has arisen as a critical gasotransmitter signaling molecule modulating cellular biological events related to health and diseases in heart, brain, liver, vascular systems and immune response.
T. Corsello +2 more
semanticscholar +1 more source
The Sirtuins Hst3 and Hst4p Preserve Genome Integrity by Controlling Histone H3 Lysine 56 Deacetylation [PDF]
, 2006 Ivana Celic +6 more
openalex +1 more source
Nutrition, sirtuins and aging [PDF]
Genes & Nutrition, 2006 Beyond our inherited genetic make-up environmental factors are central for health and disease and finally determine our life span. Amongst the environmental factors nutrition plays a prominent role in affecting a variety of degenerative processes that are linked to aging.
openaire +3 more sources
NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial
The Laryngoscope, EarlyView.This 2‐year, single‐center, double‐blind study with a small sample size compared NAD+ and control groups in a randomized controlled trial for sudden sensorineural hearing loss (SSNHL). Results showed that NAD+ led to better hearing improvement from 7 days to 3 months and a shorter average recovery time compared to the control group.
Minqian Gao +7 more
wiley +1 more source
Molecular Nutrition &Food Research, EarlyView.This retrospective study evaluated the effects of nutraceutical supplementation (NS) and a Mediterranean hypocaloric diet (MHD) in NAFLD patients. Forty‐five overweight/obese subjects followed MHD with or without NS. After 3 months, only the MHD + NS group showed significant improvements in liver steatosis indices and inflammation.
Mariana Di Lorenzo +11 more
wiley +1 more source
Sirtuin 1 Is Required for Antagonist-Induced Transcriptional Repression of Androgen-Responsive Genes by the Androgen Receptor [PDF]
, 2007 Yan Dai +5 more
openalex +1 more source
Molecular Nutrition &Food Research, EarlyView.Rutin enhances intestinal epithelial barrier function by upregulating TJ‐related proteins (ZO‐2, occludin, and claudin‐3), reducing paracellular permeability, and restoring Caco‐2 cell viability impaired by X‐ray radiation. These effects suggest rutin's potential as a natural radioprotective agent for maintaining intestinal barrier integrity under ...
Ha‐Young Park +3 more
wiley +1 more source
Serum Sirtuin 1, 3 and 6 Levels in Acute Myocardial Infarction Patients
Arquivos Brasileiros de CardiologiaBackground: Sirtuins may act in many cellular processes like apoptosis, DNA repair and lipid/glucose metabolism. Experimental studies suggested some sirtuin types may have protective effects against endothelial dysfunction, atherosclerosis, cardiac ...
Emrullah Kızıltunç +6 more
doaj +1 more source