Results 11 to 20 of about 70,767 (359)
Sirtuins, bioageing, and cancer [PDF]
Journal of Aging Research, 2011 The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins
McCaul, J. +3 more
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Journal of Cell Science, 2011 Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human and SIR2 was originally shown to extend lifespan in budding yeast ([Imai et al., 2000][1]; [Kaeberlein et al., 1999][2]).
Takashi Nakagawa, Leonard Guarente
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Mitochondrial Sirtuins in Reproduction [PDF]
Antioxidants, 2021 Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions contribute to altering the redox balance and predispose to aging and metabolic alterations. The sirtuin family is composed of seven members and three of them, SIRT3-5, are housed in mitochondria.
Di Emidio, Giovanna +5 more
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Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors [PDF]
International Journal of Molecular Sciences, 2021 Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells.
Nina Schmid +7 more
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Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy
Trends in Molecular Medicine, 2021 Diabetic cardiomyopathy is the leading cause of death among people with diabetes. Despite its severity and poor prognosis, there are currently no approved specific drugs to prevent or even treat diabetic cardiomyopathy. There is a need to understand the pathogenic mechanisms underlying the development of diabetic cardiomyopathy to design new ...
J. Francisco Nistal +8 more
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Respiratory Research, 2022 AbstractSirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA damage response, inflammation, apoptosis, autophagy, and oxidative stress.
Yahui Liu, Guochao Shi
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Effects of Hst3p inhibition in Candida albicans: a genome-wide H3K56 acetylation analysis
Frontiers in Cellular and Infection Microbiology, 2022 Candida spp. represent the third most frequent worldwide cause of infection in Intensive Care Units with a mortality rate of almost 40%. The classes of antifungals currently available include azoles, polyenes, echinocandins, pyrimidine derivatives, and ...
Marisa Conte +15 more
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Sirtuins in Neuroendocrine Regulation and Neurological Diseases
Frontiers in Neuroscience, 2018 Silent information regulator 1 (SIRT1) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as the lifespan-extending gene, silent information regulator 2 (SIRT2) in ...
Yuki Fujita +4 more
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Benefits of the Phytoestrogen Resveratrol for Perimenopausal Women
Endocrines, 2021 Endometriosis, characterized by macroscopic lesions in the ovaries, is a serious problem for women who desire conception. Damage to the ovarian cortex is inevitable when lesions are removed via surgery, which finally decreases the ovarian reserve ...
Osamu Wada-Hiraike
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It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
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