Results 11 to 20 of about 87,529 (407)
Sirtuins, bioageing, and cancer [PDF]
Journal of Aging Research, 2011 The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins
McCaul, J. +3 more
core +8 more sources
iScienceLysine lactylation (Kla), an epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, bridges metabolism and gene regulation. Enzymes such as p300 and HDAC1/3 have been pivotal in deciphering the regulatory dynamics of Kla, though questions about additional regulatory enzymes, their specific Kla substrates, and the ...
Runhua Du +13 more
semanticscholar +4 more sources
Mitochondrial Sirtuins in Reproduction [PDF]
Antioxidants, 2021 Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions contribute to altering the redox balance and predispose to aging and metabolic alterations. The sirtuin family is composed of seven members and three of them, SIRT3-5, are housed in mitochondria.
Di Emidio, Giovanna +5 more
openaire +5 more sources
Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors [PDF]
International Journal of Molecular Sciences, 2021 Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells.
Nina Schmid +7 more
openaire +2 more sources
Sirtuin family in autoimmune diseases
Frontiers in Immunology, 2023 In recent years, epigenetic modifications have been widely researched. As humans age, environmental and genetic factors may drive inflammation and immune responses by influencing the epigenome, which can lead to abnormal autoimmune responses in the body.
Zhengjie Tao +4 more
semanticscholar +1 more source
BZD9L1 Differentially Regulates Sirtuins in Liver-Derived Cells by Inducing Reactive Oxygen Species
Biomedicines, 2023 Growing evidence has highlighted that mitochondrial dysfunction contributes to drug-induced toxicities and leads to drug attrition and post-market withdrawals.
Yeuan Ting Lee +2 more
doaj +1 more source
Journal of Neuroinflammation, 2021 Background Postoperative cognitive dysfunction (POCD) is a very common complication that might increase the morbidity and mortality of elderly patients after surgery. However, the mechanism of POCD remains largely unknown.
Qiang Liu +8 more
semanticscholar +1 more source
Antioxidants, 2023 Stroke is one of the leading causes of morbidity and mortality worldwide. A main cause of brain damage by stroke is ischemia-reperfusion (IR) injury due to the increased production of reactive oxygen species (ROS) and energy failure caused by changes in ...
Vishal Chavda, Bingwei Lu
doaj +1 more source
The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta
International Journal of Molecular Sciences, 2023 Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response, autophagy, and cell response to oxidative stress. Since their discovery, sirtuins have been regarded as anti-ageing and longevity-promoting enzymes.
M. Wątroba, G. Szewczyk, D. Szukiewicz
semanticscholar +1 more source
The Emerging Role of SIRT7 in Glucose and Lipid Metabolism
Cells, 2023 Sirtuins (SIRT1–7 in mammals) are a family of NAD+-dependent lysine deacetylases and deacylases that regulate diverse biological processes, including metabolism, stress responses, and aging.
Kazuya Yamagata +2 more
doaj +1 more source