Results 191 to 200 of about 84,834 (402)

Conformational Analysis and NMR Data Assignment of Taraxerone Isolated From Cnidoscolus aconitifolius (Chaya)

Magnetic Resonance in Chemistry, EarlyView.
We report the first complete NMR assignment of taraxerone, a pentacyclic triterpenoid isolated from Cnidoscolus aconitifolius (chaya). Using 2D NMR, DFT, and NBO analysis, we resolved spectral ambiguities due to high‐order couplings and signal overlap. Two Ring A conformers were identified and characterized.
Mónica Díaz‐Fernández, Karla Cahun‐Uicab, Viviana Roche‐Llerena, Leonardo Hernández, Geonel Rodríguez‐Gattorno, Armando Ariza‐Castolo, María A. Fernández‐Herrera   +6 more
wiley   +1 more source

Sirtuins and calorie restriction [PDF]

Nature Reviews Molecular Cell Biology, 2012
Studies in mice have indicated that sirtuins do have a role in mediating the effects of CR.
openaire   +3 more sources

Synthesis and Anticancer Potential of New Benzimidazole Theranostic

ChemistryOpen, EarlyView.
Recent advances have highlighted benzimidazole's importance in anticancer drug discovery. A novel series of benzimidazole analogs is designed and synthesized, with V7 showing broad anticancer activity and selectivity, possibly linked to SIRT2 inhibition.
Sahani Sandalima Uthumange, Muhammad Azri Faiz bin Abdul Zaki, Keng Yoon Yeong   +2 more
wiley   +1 more source

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease [PDF]

, 2008
Carl Julien, Cyntia Tremblay, Vincent Émond, Meryem Lebbadi, Norman Salem, David A. Bennett, Frédéric Calon   +6 more
openalex   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

SIRT3 rs11246020 Polymorphism Associated Postprandial Triglyceride Dysmetabolism

Diabetes, Metabolic Syndrome and Obesity
Liqun Yang,1– 3 Zhimei Zhang,3 Yunfeng Zhen,3 Jing Feng,3 Jinhu Chen,3 Guangyao Song1– 3 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China; 2Hebei Key Laboratory of Metabolic Disease ...
Yang L, Zhang Z, Zhen Y, Feng J, Chen J, Song G   +5 more
doaj  

Effects of mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency on fructose-induced obesity in mice [PDF]

, 2018
Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia.
Beane, Kaleigh Elizabeth, Montalbano, Allison Michelle   +1 more
core   +2 more sources

Conserved Metabolic Regulatory Functions of Sirtuins [PDF]

, 2008
Bjoern Schwer, Eric Verdin
openalex   +1 more source

Proteomic Biomarkers Are Linked to QTc Interval in Patients With Chronic Heart Failure

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Objective This study investigates the link between circulating proteins and rate‐corrected QT (QTc) interval in patients with heart failure with reduced ejection fraction (HFrEF) and their association with cardiovascular outcomes. Methods and Results We analyzed 197 HFrEF patients from the prospective Serial Biomarker Measurements and New ...
Mylène Barry‐Loncq de Jong, Teun B. Petersen, Sabrina Abou Kamar, Navin Suthahar, Nick van Boven, K. Martijn Akkerhuis, Peter J. van der Spek, Peter D. Katsikis, Rudolf A. de Boer, Victor A. W. M. Umans, Eric Boersma, Folkert W. Asselbergs, Jasper J. Brugts, Sing‐Chien Yap, Isabella Kardys   +14 more
wiley   +1 more source

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect [PDF]

, 2008
Ester Lara, Antonello Mai, Vincenzo Calvanese, Lucia Altucci, Pilar López‐Nieva, María Luz Martínez‐Chantar, Marta Varela‐Rey, Dante Rotili, Angela Nebbioso, Santiago Ropero, Guillermo Montoya, Julen Oyarzábal, Sheyla Velasco, Manuel Serrano, M Witt, Ana Villar‐Garea, A Inhof, José M. Mato, Manel Esteller, Mario F. Fraga   +19 more
openalex   +1 more source