Results 211 to 220 of about 84,834 (402)

Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels

Aging Cell, EarlyView.
RNAi knockdown (KD) of mcu‐1 or mitoxantrone treatment lowers mitochondrial Ca2+, extends lifespan, and preserves motility during aging. Benefits require early intervention and involve a transient ROS increase that activates a pmk‐1, daf‐16, and skn‐1 pathway, enhancing stress defense and mitochondrial integrity while reducing early‐life survival ...
Doruntina Bresilla, Ines Tawfik, Martin Hirtl, Sonja Gabrijelčič, Julian Ostaku, Fabienne Mossegger, Lia Wurzer, Susanne Lederer, Katarina Kalinova, Ernst Malle, Markus Schosserer, Kim Zarse, Michael Ristow, Corina T. Madreiter‐Sokolowski   +13 more
wiley   +1 more source

Resveratrol, sirtuins, and the promise of a DR mimetic [PDF]

, 2010
Joseph A. Baur
openalex   +1 more source

Liver molecular networks associated with drinking behavior in nonhuman primates

Alcohol, Clinical and Experimental Research, EarlyView.
We identified hepatic molecular networks that differed between light drinkers (LD) and very heavy drinkers (VHD) before they were exposed to alcohol, as well as epigenetic differences between LD and VHD in response to the same amount of alcohol.
Laura A. Cox, James B. Daunais, Timothy D. Howard, Ge Li, Sobha Puppala, Jeannie Chan, Zeeshan Hamid, Samer Gawrieh, Sun Mi Lee, Betsy Ferguson, Kathleen A. Grant, Michael Olivier   +11 more
wiley   +1 more source

Download the full PDF of Jefferson Surgical Solutions Spring 2009, Volume 4, Number 1. [PDF]

, 2009
Download the full PDF of Jefferson Surgical Solutions Spring 2009, Volume 4, Number ...

core   +1 more source

Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose [PDF]

, 2010
Lei Tong, John M. Denu
openalex   +1 more source

Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes

Allergy, EarlyView.
In the BILD and BLT cohorts, we compared cord blood proteins in infants of mothers with and without asthma during pregnancy. Groups showed different protein levels. These markers were associated with postnatal lung function, bronchiolitis hospitalization, and asthma.
Carla Rebeca Da Silva Sena, Gabriela Martins Costa Gomes, Noëmi Künstle, Olga Gorlanova, Andrea Marten, Sven Schulzke, Florian Wyler, Vanessa E. Murphy, Paul D. Robinson, Peter D. Sly, Jakob Usemann, Benjamin Stoecklin, Ruth Steinberg, Sophie Yammine, Loretta Müller, Philipp Latzin, Pablo Sinues, Peter G. Gibson, Joerg Mattes, Adam Collison, Urs Frey, on behalf of the BILD and BLT Study Groups   +21 more
wiley   +1 more source

Unraveling the Role of AtSRT2 in Energy Metabolism, Stress Responses, and Gene Expression during Osmotic Stress in Arabidopsis thaliana

Plants
Sirtuins participate in chromatin remodeling and gene expression regulation during stress responses. They are the only deacetylases that couple the cellular NAD+-dependent energy metabolism with transcriptional regulation. They catalyze the production of
Alberto Obrecht, Manuel Paneque
doaj   +1 more source

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria [PDF]

, 2010
Katia Aquilano, Paola Vigilanza, Sara Baldelli, Beatrice Pagliei, Giuseppe Rotilio, Maria Rosa Ciriolo   +5 more
openalex   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Sirtuin-1 regulation of mammalian metabolism [PDF]

, 2010
Matthew P. Gillum, Derek M. Erion, Gerald I. Shulman   +2 more
openalex   +1 more source