Results 231 to 240 of about 69,505 (315)

SIRT1/3/6 Landscape of Human Longevity: A Sex- and Health-Stratified Pilot Study. [PDF]

Biology (Basel)
Hashimova U, Kvetnoy I, Gaisina A, Safikhanova K, Mironova E, Galandarli I, Hasanli L.   +6 more
europepmc   +1 more source

Cerebrospinal Fluid Genetics Enhance Risk Stratification in Bipolar Disorder

MedComm, Volume 7, Issue 3, March 2026.
This study introduced a novel genetic proxy strategy that connects the CSF biomarkers with the clinical applications in BD research. First, it delineated a genetically anchored CSF biomarker network. Second, it demonstrated the clinical utility of multimodal PRS. Finally, it provided a scalable framework for risk stratification. These insights pave the
Yu Feng, Xiaonan Guo, Peng Huang, Xiaolong Ji, Ningning Jia, Sheng Yang, Shaohua Hu   +6 more
wiley   +1 more source

Elevated Sirtuin 1 Levels in Patients with Chronic Kidney Disease, Including on Peritoneal Dialysis: Associations with Cardiovascular Risk and Peritoneal Fibrosis. [PDF]

Int J Mol Sci
Bielach-Bazyluk A, Czajkowska K, Koc-Zorawska E, Hryszko T, Zbroch E.   +4 more
europepmc   +1 more source

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
wiley   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling. [PDF]

Sci Rep
Seo MK, Lee JG, Kim JH, Seog DH, Jeong S, Kim SH, Lee JY, Park SW.   +7 more
europepmc   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Evaluation of Copper-Induced Cytotoxicity and Transcriptomic Change Using a RTgill-W1 Cell Line as an Alternative Replacing Fish Test. [PDF]

Toxics
Lee JW, Shim I, Park K.
europepmc   +1 more source

SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer

MedComm – Oncology, Volume 5, Issue 1, March 2026.
In tamoxifen‐sensitive breast cancer, SIRT7 deacetylates ERα at lysines 302 and 303, promoting CHIP‐mediated, ubiquitin‐dependent proteasomal degradation of ERα and thereby restraining estrogen‐driven tumor growth. By contrast, during tamoxifen treatment, enhanced interaction between SIRT7 and ERα redirects deacetylated ERα toward activation of EGFR ...
Yalan Wu, Huixia Liu, Ye Liu, Yanxue Mei, Mengdi Cao, Guo Li, Ronghui Fan, Junfeng Zhang, Langmei Yang, Jieling Liu, Qi Hou, Jinsong Li, Fujun Dai, Baohua Liu, Xiaolong Tang   +14 more
wiley   +1 more source

Role of SIRT3 in digestive system diseases and therapeutic prospects (Review). [PDF]

Int J Mol Med
Li J, Liu Q, Yao S, Li X, Zhang L, Wang Y, Wen G, An J, Jin H, Tuo B.   +9 more
europepmc   +1 more source