Results 241 to 250 of about 87,529 (407)

<p>MicroRNA-506 regulates apoptosis in retinoblastoma cells by targeting sirtuin 1</p>

, 2019
Zhidu Song, Hailiang Wang, Fangwei Zong, Chao Zhu, Tao Ying   +4 more
openalex   +2 more sources

Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease

Glia, Volume 74, Issue 3, March 2026.
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar, Yucheng Xiao, Neha Mahajan, Qianyi Luo, Theodore R. Cummins, Adrian L. Oblak, Bruce T. Lamb, Timothy W. Corson, Ashay D. Bhatwadekar   +8 more
wiley   +1 more source

Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment. [PDF]

World J Clin Oncol
Zhao HY, Yu CY, Ye XT, Qian ST, Huang Y, Liu QS.   +5 more
europepmc   +1 more source

Relationship Between Sirtuin 1 and Sirtuin 2 with Type 2 Diabetes

, 2021
İlke ULU, Güneş Çakmak Genç, Sevim Çelik   +2 more
openalex   +1 more source

Sirtuins Positively Regulate KATP Channels, Which Contributes to their Cardioprotective Role [PDF]

, 2019
Erkan Tuncay, Hua-Qian Yang, Ivan Gando, Belma Turan, Ravichandran Ramasamy, William A. Coetzee   +5 more
openalex   +1 more source

Targeting Delivery of Cyanidin‐Loaded With Ti3C2 Nanosheets for Alleviating Vascular Calcification in Chronic Kidney Disease

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Vascular calcification significantly elevates cardiovascular risk in CKD patients, yet no effective therapies exist to halt its progression. We developed a dual targeting nanoplatform Ti3C2/RANKL/OCN/Cyanidin (TROC) for the targeted delivery of cyanidin against vascular calcification.
Li Yin, Xiaoge Zhang, Huanji Zhang, Changming Xie, Zhengzhipeng Zhang, Dong Wang, Yuning Liu, Bing Dong, Leilei Shi, Jie Liu, Hui Huang   +10 more
wiley   +1 more source

Plasma levels of sirtuin 1 and sirtuin 2 in ascending aortic aneurysm patients - a comparative study. [PDF]

Cardiol J
Krekora J, Matuszewska-Brycht O, Fryczak J, Stępiński P, Krejca M, Siejka A, Kaczmarek D, Merks P, Drożdż J.   +8 more
europepmc   +1 more source

Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors

, 2012
Takayoshi Suzuki, M. Naseer A. Khan, Hideyuki Sawada, Erika Imai, Yukihiro Itoh, Katsura Yamatsuta, Natsuko Tokuda, Jun Takeuchi, Takuya Seko, Hidehiko Nakagawa, Naoki Miyata   +10 more
openalex   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Association of sirtuin 1 rs10997868 and rs730821 polymorphisms with sirtuin 1 and hydroxy-2'-deoxyguanosine levels in healthy smokers: A case-control study. [PDF]

J Int Med Res
Sultan S.
europepmc   +1 more source