Results 241 to 250 of about 69,505 (315)

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Investigating the Origins of Biochemical Dysregulation in Trisomy 21 Pregnancy.

J Clin Endocrinol Metab
Buczyńska A, Sidorkiewicz I, Krętowski AJ, Zbucka-Krętowska M.   +3 more
europepmc   +1 more source

Interplay of oxidative stress and Inflammasome activation and clinical indices in Parkinson's disease: insights from serum SIRT1, Nrf2, and NLRP3 levels and PDQ-39-a cross-sectional study. [PDF]

Front Neurosci
Aldossary KM, Hamza E, Kamel MM, Alsegiani AS, Alrubia S, Sarawi WS, El-Khateeb E, Eltantawy N, Mourad SA, Elshorbagi N, Khrieba MO.   +10 more
europepmc   +1 more source

Risk of Incident Colorectal Carcinoma in Patients With Type 2 Diabetes on SGLT‐2 Inhibitor Users

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 3, March 2026.
ABSTRACT Background The role of sodium‐glucose co‐transporter‐2 inhibitor (SGLT2I) in colorectal carcinoma (CRC) risk in patients with type 2 diabetes mellitus (T2D) remains controversial. This study aimed to examine the association between SGLT2I use and the risk of incident CRC in patients with T2D.
Tsung‐Kun Lin, Wei‐Yao Wang, Jing‐Yang Huang, Yeu‐Sheng Tyan, Mei‐Chun Chen, Gwo‐Ping Jong, Dorji Harnod   +6 more
wiley   +1 more source

Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism. [PDF]

Acta Physiol (Oxf)
Byrne NJ, Koentges C, Pfeil K, Lueg JC, Bakshi S, Tarkhnishvili A, Vosko I, Gollmer J, Birkle LC, Rathner T, Birkle S, Tang S, Rau C, Hoffmann MM, Odening KE, Barnes S, Wilson LS, Ljubojevic-Holzer S, Wallner M, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Wende AR, Zirlik A, Bugger H.   +26 more
europepmc   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, Volume 40, Issue 3, Page 965-985, March 2026.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

Multi-omics integration and machine learning unveil FOXO3/SIRT1 axis as oxidative stress biomarkers and therapeutic targets in osteoporosis. [PDF]

Medicine (Baltimore)
Zheng S, Luo X, Chen G, Wang P.
europepmc   +1 more source

Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut–Liver Axis Homeostasis

Aging Cell, Volume 25, Issue 3, March 2026.
The age‐related mitochondrial energy crisis and the consequent disruption of intestinal HDL3 biosynthesis converge to disrupt the gut–liver HDL3‐LPS/TLR4 axis, compromising hepatic anti‐inflammatory function and driving liver injury, an effect reversible upon NMN administration.
Yumeng Li, Tongtong Bao, Lumin Gao, Xutong Tian, Junyu Xue, Caike Jin, Shujin Wang, Xin Wu   +7 more
wiley   +1 more source

Research progress on sirtuin family genes in colorectal cancer. [PDF]

Front Oncol
Liu T, Wu T, Luo L, Li W, Zhang M.
europepmc   +1 more source