Results 21 to 30 of about 87,529 (407)
Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases
Frontiers in Aging Neuroscience, 2022 Sirtuins are protein factors that can delay aging and alleviate age-related diseases through multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere shortening, and mediating the longevity effect of caloric restriction.
W. Wan +7 more
semanticscholar +1 more source
mSphere, 2022 Candida parapsilosis is an emerging fungal pathogen that primarily affects immunocompromised patients in hospitals. A significant risk factor is the use of implanted medical devices, which support the growth of biofilms composed of a mixture of ...
Christopher B. Rupert, Laura N. Rusche
doaj +1 more source
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
Theranostics, 2020 Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism of multiple organs. Hitherto, SIRT3 has been substantiated
Jin Zhang +5 more
semanticscholar +1 more source
Sirtuin modulators: past, present, and future perspectives.
Future Medicinal Chemistry, 2022 Sirtuins are NAD+-dependent protein lysine deacylase and mono-ADP ribosylases present in both prokaryotes and eukaryotes. The sirtuin family comprises seven isoforms in mammals, each possessing different subcellular localization and biological functions.
Francesco Fiorentino +5 more
semanticscholar +1 more source
Hepatology, 2021 Sirtuin 2 (SIRT2), an NAD+‐dependent deacetylase, is involved in various cellular processes regulating metabolic homeostasis and inflammatory responses; however, its role in hepatic steatosis and related metabolic disorders is unknown.
Hui-Hui Ren +8 more
semanticscholar +1 more source
, 2011 Members of the sirtuin family including the founding protein Sir2 in Saccharomyces cerevisiae have been linked to lifespan extension in simple organisms. This finding prompted evaluation of the role of Sir2 orthologues in many aging-associated conditions including neurodegeneration, type II diabetes and cancer.
Sumit S, Mahajan +3 more
openaire +2 more sources
Roles of sirtuin family members in chronic obstructive pulmonary disease
Respiratory Research, 2022 The globally increasing annual incidence of chronic obstructive pulmonary disease (COPD), a common chronic disease, poses a serious risk to public health. Although the exact mechanism underlying the pathogenesis of COPD remains unclear, a large number of
Xiyue Zhang +5 more
semanticscholar +1 more source
Hepatology, 2021 Aging exacerbates liver neutrophil infiltration and alcohol‐associated liver disease (ALD) in mice and humans, but the underlying mechanisms remain obscure. This study aimed to examine the effect of aging and alcohol consumption on neutrophilic Sirtuin 1
Ruixue Ren +12 more
semanticscholar +1 more source
Sirtuins in Neuroendocrine Regulation and Neurological Diseases
Frontiers in Neuroscience, 2018 Silent information regulator 1 (SIRT1) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as the lifespan-extending gene, silent information regulator 2 (SIRT2) in ...
Yuki Fujita +4 more
doaj +1 more source
It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core +2 more sources