Results 41 to 50 of about 65,710 (330)
Clinical Interventions in Aging, 2021 Angelika Bielach-Bazyluk,1 Edyta Zbroch,2 Katarzyna Czajkowska,1 Ewa Koc-Zorawska,1 Katarzyna Kakareko,1 Alicja Rydzewska-Rosolowska,1 Tomasz Hryszko1 1 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok ...
Bielach-Bazyluk A +6 more
doaj
Decreased Serum Sirtuin-1 in COPD [PDF]
Chest, 2017 The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD.Serum SIRT1 protein of all samples was measured by Western blot, and the SIRT1 protein band ...
Yanagisawa, S +7 more
openaire +4 more sources
The long-term effect of moderate-intensity exercise on the expression of the genes irisin and sirtuin-1 in the skeletal muscle of diabetic rats with streptozotocin [PDF]
Journal of Exercise & Organ Cross Talk, 2022 Disorders of glucose metabolism in various tissues, including skeletal muscle tissue and adipose tissue are features of diabetes. The aim of the present study was to evaluate the long-term effect of moderate-intensity continuous exercise on the ...
Alireza Mohammadi, Mania Roozbayani
doaj +1 more source
Inverse association of circulating SIRT1 and adiposity. A study on underweight, normal weight, and obese patients [PDF]
, 2018 Context: Sirtuins (SIRTs) are NAD+-dependent deacetylases, cellular sensors to detect energy availability, and modulate metabolic processes. SIRT1, the most studied family member, influences a number of tissues including adipose tissue.
Barbaro G +14 more
core +1 more source
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
Sirtuin 1 (SIRT1): The Misunderstood HDAC [PDF]
SLAS Discovery, 2011 The sirtuin family of NAD-dependent histone deacetylases (HDACs) consists of seven mammalian proteins, SIRT1-7. Many of the sirtuin isoforms also deacetylate nonhistone substrates, such as p53 (SIRT1) and α-tubulin (SIRT2). The sirtuin literature focuses on pharmacological activators of SIRT1 (e.g., resveratrol, SRT1720), proposed as therapeutics for ...
Walter, Stünkel, Robert M, Campbell
openaire +2 more sources
Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review
Cells, 2021 Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic causative factors of aging. Intrinsic aging is related to compromised cellular proliferative capacity, and may be accelerated by harmful environmental ...
Angelika Bielach-Bazyluk +6 more
doaj +1 more source
Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]
, 2017 A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie +13 more
core +2 more sources
Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1 [PDF]
Experimental & Molecular Medicine, 2021 AbstractSirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase that plays diverse physiological roles. However, little is known about the regulation of SIRT1 activity. Here, we show that phospholipase D2 (PLD2), but not PLD1, selectively interacts with SIRT1 and increases the deacetylase activity of SIRT1.
Lee, Hyesung +5 more
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Regulation of the Mitogen Activated Protein Kinase Kinase (MEK)-1 by NAD-Dependent Deacetylases [PDF]
, 2014 Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability, and metabolism. Although these NAD+-dependent deacetylases control adaptive cellular responses, identification of sirtuin-regulated ...
A Duffy +34 more
core +2 more sources