Sirtuins as Therapeutic Targets for Treating Cancer, Metabolic Diseases, and Neurodegenerative Diseases [PDF]
PharmaceuticalsSirtuins are NAD+-dependent enzymes that are conserved in all domains of life, including mammals, metazoans, plasmodia, yeast, bacteria, and archaea. In humans, there are seven isoforms (SIRT1 to 7), and they function in cellular homeostasis, aging, DNA ...
Maxwell Akantibila, Valerie J. Carabetta
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Sirtuins in Women’s Health [PDF]
PharmaceuticalsThe human sirtuins (SIRT1–SIRT7) are NAD+-dependent protein deacylases that orchestrate key cellular events such as metabolism, stress response, DNA repair, and aging. Accumulating evidence highlights their central role in women’s health.
Rasajna Madhusudhana +4 more
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Changed Serum Levels of Sirtuin1 and Sirtuin3 and Their Correlations with Sleep Quality and Cognitive Function in Patients with Chronic Insomnia Disorder [PDF]
Nature and Science of SleepGao-Xia Liu, Yu Zhang, Yang Song, Shuai Yang, Ai-Xi Su, Yi-Zhou Feng, Yu-Shun Zhou, Zi-Jie Ma, Lan Xia, Gui-Hai Chen Department of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei, People’s Republic of ...
Liu GX +9 more
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gdSir2.1 and gdSir2.3 are involved in albendazole resistance in Giardia duodenalis via regulation of the oxidative stress response [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceAlbendazole resistance in Giardia duodenalis includes a complex and multifactorial challenge that potentially involves non-reported pathways such as the participation of metabolic regulators.
Adrián Chávez-Cano +2 more
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Sirtuin family in lung adenocarcinoma [PDF]
Discover OncologyLung cancer is a highly aggressive malignancy that accounts for one of the greatest mortality rate in humans globally. Among various types of lung malignancies, lung adenocarcinoma (LUAD) stands out as the most common form. Sirtuins (SIRTs) are class III
Cui Chen +5 more
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Implications of altered sirtuins in metabolic regulation and oral cancer [PDF]
PeerJ, 2023 Sirtuins (SIRTs 1-7) are a group of histone deacetylase enzymes with a wide range of enzyme activities that target a range of cellular proteins in the nucleus, cytoplasm, and mitochondria for posttranslational modifications by acetylation (SIRT1, 2, 3 ...
Xu Quan +5 more
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Biology, 2021 Sirtuins are a family of highly conserved NAD+-dependent proteins and this dependency links Sirtuins directly to metabolism. Sirtuins’ activity has been shown to extend the lifespan of several organisms and mainly through the post-translational ...
Parcival Maissan +2 more
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Bacterial Sirtuins Overview: An Open Niche to Explore
Frontiers in Microbiology, 2021 Sirtuins are deacetylase enzymes widely distributed in all domains of life. Although for decades they have been related only to histones deacetylation in eukaryotic organisms, today they are considered global regulators in both prokaryotes and eukaryotes.
Julia Gallego-Jara +5 more
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Virtual Screening in the Identification of Sirtuins’ Activity Modulators
Molecules, 2022 Sirtuins are NAD+-dependent deac(et)ylases with different subcellular localization. The sirtuins’ family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates include histones and also an increasing number of different proteins. Sirtuins
Elena Abbotto +5 more
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Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases
Frontiers in Physiology, 2022 Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively studied in regulating ageing and age-related diseases.
Zijian Pan +4 more
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