Results 181 to 190 of about 17,907 (258)

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
wiley   +1 more source

The Yin-Yang balance of SIRT1 and SIRT2 in cancer metabolic remodeling. [PDF]

Int J Biol Sci
Yi F, Shen L, Yang X, Wang Z, Li X, Shen Z, Liu W, Miao Q, Jiang S, Kong E, Song X, Zhou T, Bai N, Cao L.   +13 more
europepmc   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

Mitochondria and Epigenetic Regulation: Bidirectional Crosstalk and Emerging Mitochondria-Targeted Degron Tools. [PDF]

Cells
Xu Y, Jian X, Shi L, Shock LS, Chen L, Chow LT, Wang H.   +6 more
europepmc   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Sirtuins and their role in ovarian aging-related fibrosis predisposing to ovarian cancer. [PDF]

NPJ Aging
Grzeczka A, Skowronska A, Sepe S, Skowronski MT, Kordowitzki P.   +4 more
europepmc   +1 more source

SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer

MedComm – Oncology, Volume 5, Issue 1, March 2026.
In tamoxifen‐sensitive breast cancer, SIRT7 deacetylates ERα at lysines 302 and 303, promoting CHIP‐mediated, ubiquitin‐dependent proteasomal degradation of ERα and thereby restraining estrogen‐driven tumor growth. By contrast, during tamoxifen treatment, enhanced interaction between SIRT7 and ERα redirects deacetylated ERα toward activation of EGFR ...
Yalan Wu, Huixia Liu, Ye Liu, Yanxue Mei, Mengdi Cao, Guo Li, Ronghui Fan, Junfeng Zhang, Langmei Yang, Jieling Liu, Qi Hou, Jinsong Li, Fujun Dai, Baohua Liu, Xiaolong Tang   +14 more
wiley   +1 more source

Pulmonary Arterial Hypertension: Reconfiguring the Vascular Landscape to Reverse Remodeling. [PDF]

Cells
Vassiliou AG, Papavassiliou KA, Lotsios NS, Orfanos SE, Papavassiliou AG.   +4 more
europepmc   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source