Results 221 to 230 of about 17,907 (258)
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Sirtuins: Multifaceted Drug Targets
Current Molecular Medicine, 2011Sirtuin (Sir2) proteins being key regulators of numerous cellular processes have been, over the recent past, the subject of intense study. Sirs have been implicated in diverse physiological processes ranging from aging and cancer to neurological dysfunctions.
Chakrabarty, SP +2 more
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Epigenetics, sirtuins and osteoarthritis
Joint Bone Spine, 2012Epigenetics, modifications of the DNA other than changes on the DNA sequences, is frequently studied in cancer research and aging. DNA methylation, mi-RNA, and histones deacetylation are investigated in different pathologies, including inflammatory diseases and age-related diseases such as osteoarthritis (OA).
Gabay, Odile, Sanchez, Christelle
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Annual Review of Biochemistry, 2006
Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose.
Anthony A, Sauve +3 more
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Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose.
Anthony A, Sauve +3 more
openaire +2 more sources
Sirtuins, epigenetics and longevity
Ageing Research Reviews, 2017Aging of organisms begins from a single cell at the molecular level. It includes changes related to telomere shortening, cell senescence and epigenetic modifications. These processes accumulate over the lifespan. Research studies show that epigenetic signaling contributes to human disease, tumorigenesis and aging.
Marta Skoda +2 more
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Resveratrol, sirtuins, and viruses
Reviews in Medical Virology, 2015SummaryResveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti‐oxidant, anti‐proliferation, anti‐inflammation, anti‐cancer ...
Tao, Yang +5 more
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Plant Science, 2020
The sirtuin family of intracellular enzymes are able to catalyze a unique β-nicotinamide adenine dinucleotide (β-NAD+)-dependent Nε-acyl-lysine deacylation reaction on histone and non-histone protein substrates. Since 2000, the sirtuin family members have been identified in both prokaryotes and eukaryotes; tremendous accomplishments have also been ...
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The sirtuin family of intracellular enzymes are able to catalyze a unique β-nicotinamide adenine dinucleotide (β-NAD+)-dependent Nε-acyl-lysine deacylation reaction on histone and non-histone protein substrates. Since 2000, the sirtuin family members have been identified in both prokaryotes and eukaryotes; tremendous accomplishments have also been ...
openaire +2 more sources
Sirtuins in atherosclerosis: guardians of healthspan and therapeutic targets
Nature Reviews Cardiology, 2022Mandy O J Grootaert, Martin R Bennett
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NAD+ metabolism and its roles in cellular processes during ageing
Nature Reviews Molecular Cell Biology, 2020Anthony J Covarrubias +2 more
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