Results 21 to 30 of about 17,907 (258)
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism [PDF]
Physiological Reviews, 2012 The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria ...
Ruben, Nogueiras +9 more
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Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans
Frontiers in Aging Neuroscience, 2017 Sirtuins are a class of histone deacetylases (HDACs) that have been shown to regulate a range of pathophysiological processes such as cellular aging, inflammation, metabolism, and cell proliferation. There are seven mammalian Sirtuins (SIRT1-7) that play
Hongdou Luo +7 more
doaj +1 more source
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
The Contentious History of Sirtuin Debates
Rambam Maimonides Medical Journal, 2012 The sirtuins are highly conserved enzyme homologues of the yeast Sir2, with activities of NAD+ dependent deacetylase and/or mono ADP ribosyltransferase.
Shoshana Naiman, Haim Y. Cohen
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Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Assaying Chromatin Sirtuins [PDF]
, 2013 Most of the sirtuins' nuclear substrates identified so far are histones or other chromatin-associated proteins and, thus, it is of special relevance the development of good biochemical techniques to analyze the biology of these proteins in the context of chromatin.
Zhong, Lei +4 more
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RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Regulation of sirtuin function by posttranslational modifications
Frontiers in Pharmacology, 2012 Sirtuins are homologs of the yeast silencing information regulator 2 (Sir2) protein, an NAD+-dependent (histone) deacetylase. In mammals 7 different sirtuins, SIRT1-7, have been identified, which share a common catalytic core domain but possess distinct ...
Franziska eFlick, Bernhard eLüscher
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Frontiers in Oncology, 2020 Sirtuins, class III histone deacetylases, are involved in multiple biological processes in cancer initiation and progression. However, the diverse expression patterns and prognostic values of sirtuins in cancers have yet to be elucidated.
Ying Tan +4 more
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Cell, 2014 The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct ...
Anderson, Kristin A. +4 more
openaire +2 more sources