Results 31 to 40 of about 17,907 (258)
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Sirtuins—The New Important Players in Women’s Gynecological Health
Antioxidants, 2021 The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma ...
Ewa Maria Kratz +3 more
doaj +1 more source
Retinal Aging and Sirtuins [PDF]
Ophthalmic Research, 2010 The process of aging involves the accumulating changes in the microenvironment that lead to cell senescence or apoptosis, and subsequent tissue or organ dysfunction. Multiple extrinsic and intrinsic events that cause DNA instability are associated with aging.
Yoko, Ozawa +6 more
openaire +2 more sources
Frontiers in Cardiovascular Medicine, 2022 Vascular calcification (VC) is a common pathological change in many chronic diseases, such as diabetes and chronic kidney disease. It is mainly deposited in the intima and media of vessels in the form of hydroxyapatite.
Shuangshuang Wang, Siwang Hu
doaj +1 more source
The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases
Journal of Cardiovascular Development and Disease, 2023 Sirtuins belong to the class III histone deacetylases and possess nicotinamide adenine dinucleotide-dependent deacetylase activity. They are involved in the regulation of multiple signaling pathways implicated in cardiovascular diseases.
Yuqin Wang +5 more
doaj +1 more source
Sirtuin chemical mechanisms [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010 Sirtuins are ancient proteins widely distributed in all lifeforms of earth. These proteins are universally able to bind NAD(+), and activate it to effect ADP-ribosylation of cellular nucleophiles. The most commonly observed sirtuin reaction is the ADP-ribosylation of acetyllysine, which leads to NAD(+)-dependent deacetylation.
openaire +2 more sources
Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain
Animal, 2013 Sirtuins, NAD-dependent histone deacetylase (HDAC), are correlated to aging and antioxidant. The aim of this study was to determine breed differences of porcine Sirtuins expression and antioxidant capacity in brain between Jinhua pigs (a fatty breed of ...
Y. Ren +5 more
doaj +1 more source
Translational Medicine of Aging, 2021 Caloric restriction (CR) is considered one of the most efficient interventions that extend lifespan and healthspan by delaying the onset of many age-related diseases in a variety of organisms.
Martin Maldonado +5 more
doaj +1 more source
Oncometabolic role of mitochondrial sirtuins in glioma patients.
PLoS ONE, 2023 Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In cancer, these sirtuins play dichotomous role as tumor suppressor and promoter.
Maria Fazal Ul Haq +7 more
doaj +2 more sources
Frontiers in Neuroscience, 2020 Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes.
Pavithra Chandramowlishwaran +9 more
doaj +1 more source