Results 21 to 30 of about 354,238 (282)

Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site [PDF]

, 2002
Background: Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P-2).
Ampe, Christophe, Dewitte, Daisy, Jonckheere, Veronique, Lambrechts, Anja, Vandekerckhove, Joël   +4 more
core   +3 more sources

The carboxyl terminus in apolipoprotein E2 and the seven amino acid repeat in apolipoprotein E-Leiden: role in receptor-binding activity

Journal of Lipid Research, 1998
Both apolipoprotein (apo) E2 and apoE-Leiden (tandem repeat of amino acids 121–127) are associated with type III hyperlipoproteinemia and bind defectively to low density lipoprotein receptors. Removing the carboxyl terminus of both variants (residues 192–
Li-Ming Dong, Thomas L. Innerarity, Kay S. Arnold, Yvonne M. Newhouse, Karl H. Weisgraber   +4 more
doaj   +1 more source

Frog foams and natural protein surfactants [PDF]

, 2017
Foams and surfactants are relatively rare in biology because of their potential to harm cell membranes and other delicate tissues. However, in recent work we have identified and characterized a number of natural surfactant proteins found in the foam ...
Cooper, Alan, Kennedy, Malcolm W., Smith, Brian O., Vance, Steven J.   +3 more
core   +1 more source

Genetic and biochemical analyses of chromosome and plasmid gene homologues encoding ICL and ArCP domains in Vibrioanguillarum strain 775 [PDF]

, 2011
Anguibactin, the siderophore produced by Vibrio anguillarum 775 is synthesized from 2,3-dihydroxybenzoic acid (DHBA), cysteine and hydroxyhistamine via a nonribosomal peptide synthetase (NRPS) mechanism.
AF Alice, AM Gehring, B Schwyn, C Notredame, CG Marshall, DH Figurski, EJ Drake, EL Arnow, F Bolivar, F Rusnak, H Naka, HW Boyer, J Frey, J Sambrook, JF Parsons, JF Staab, JH Crosa, JH Crosa, Jorge H. Crosa, JR Lai, JR Pollack, KA Datsenko, LA Actis, LA Actis, LE Quadri, M Balado, M Di Lorenzo, M Di Lorenzo, M Di Lorenzo, M Hahn, M Jalal, M Stork, MA Walter, Manuela Di Lorenzo, ME Tolmasky, ME Tolmasky, Michiel Stork, MK Wolf, PA Bates, Q Chen, RF Conchas, SF Altschul, TA Keating, TJ Welch   +43 more
core   +2 more sources

In silico Analysis and Site-directed Mutagenesis of Promoters

Bio-Protocol, 2017
In normal as in cancerous cells, gene expression is tightly regulated by transcription factors, which are responsible for up- or down-regulation of thousands of targets involved in different cell processes. Transcription factors can directly regulate the
Salah Boudjadi, Jean-François Beaulieu
doaj   +1 more source

Site-directed mutation of a laccase from Thermus thermophilus: Effect on the activity profile [PDF]

Archives of Biological Sciences, 2012
A site-directed mutant R453T of a laccase from Thermus thermophilus HB27 (Tth-laccase) was constructed in order to investigate the effect on laccase catalytic properties. The mutated gene was cloned and overexpressed in Escherichia coli.
Liu Xin, Tian Meng, Liu Kewu
doaj   +1 more source

Strategies for studying permeation at voltage-gated ion channels [PDF]

, 1991
Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways.
Lester, Henry A.
core   +1 more source

Improved immobilization of laccase on a glassy carbon electrode by oriented covalent attachment [PDF]

Archives of Biological Sciences, 2014
A laccase from Thermus thermophilus HB27 was reported to be potentially useful in the design of a temperature controlled biofuel cell. For enhancing its application in different thermal conditions, we engineered a laccase-oriented immobilized ...
Liu Xin, Liu Kewu
doaj   +1 more source

A membrane-inserted structural model of the yeast mitofusin Fzo1 [PDF]

, 2017
Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and are required for the tethering and fusion of mitochondrial outer membranes.
A Fiser, A Franco, A Lupas, A Sali, A Santel, AA Polyansky, AB Knott, AM Bertholet, B Brosig, B Hess, B Westermann, C Notredame, C Volland, CR Søndergaard, D Naon, D Rapaport, DT Jones, DT Jones, E Boutet, EE Griffin, EF Pettersen, EG Hutchinson, F Anton, F Anton, F Armougom, F Sievers, G Pollastri, GJ Hermann, H Kishida, H Sesaki, H Viklund, HH Low, HH Low, HJC Berendsen, HM Berman, IM Wallace, JM Mason, JS Chappie, K Hofmann, K Labbé, L Cavellini, L Yan, L Yan, M Escobar-Henriques, M Rojo, M-P Durrieu, M-Y Shen, MA Lemmon, MA Lomize, MM Cohen, MS Longtine, N Ishihara, NJ Gleason, O Daumke, OM Brito de, P Hubert, R Filadi, R Yan, RA Laskowski, RA Laskowski, RFS Walters, RL Dunbrack, S Fritz, S Jo, S Lee, S-Q Zhang, SF Altschul, T Darden, T Koshiba, T Nugent, T Shutt, TJ Dolinsky, VB Chen, W Kabsch, WL Jorgensen, X Bian, X Daura, Y Qi, Y-L Cao   +78 more
core   +4 more sources

Current status and emerging frontiers in enzyme engineering: An industrial perspective

Heliyon
Protein engineering mechanisms can be an efficient approach to enhance the biochemical properties of various biocatalysts. Immobilization of biocatalysts and the introduction of new-to-nature chemical reactivities are also possible through the same ...
Obinna Giles Ndochinwa, Qing-Yan Wang, Oyetugo Chioma Amadi, Tochukwu Nwamaka Nwagu, Chukwudi Innocent Nnamchi, Emmanuel Sunday Okeke, Anene Nwabu Moneke   +6 more
doaj   +1 more source