Results 31 to 40 of about 352,666 (292)
Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. [PDF]
PLoS ONE, 2009 Ubiquitin ligase Atrogin1/Muscle Atrophy F-box (MAFbx) up-regulation is required for skeletal muscle atrophy but substrates and function during the atrophic process are poorly known.
Julie Lagirand-Cantaloube +5 more
doaj +1 more source
British Journal of Pharmacology, 2021 Muscle protein catabolism in patients with diabetic nephropathy (DN) results in striking loss of muscle proteins, which increases morbidity and mortality risks.
Gang Tang +7 more
semanticscholar +1 more source
IL-6-induced skeletal muscle atrophy [PDF]
Journal of Applied Physiology, 2005 Chronic, low-level elevation of circulating interleukin (IL)-6 is observed in disease states as well as in many outwardly healthy elderly individuals. Increased plasma IL-6 is also observed after intense, prolonged exercise. In the context of skeletal muscle, IL-6 has variously been reported to regulate carbohydrate and lipid metabolism, increase ...
Haddad, F. +3 more
openaire +4 more sources
Biochemical Pharmacology, 2022 Pathophysiological changes of skeletal muscle occur in a variety of chronic diseases, leading to muscle atrophy and dysfunction, which greatly affect the quality of life.
Wei Wang +11 more
semanticscholar +1 more source
Regulation of Skeletal Muscle Atrophy in Cachexia by MicroRNAs and Long Non-coding RNAs
Frontiers in Cell and Developmental Biology, 2020 Skeletal muscle atrophy is a common complication of cachexia, characterized by progressive bodyweight loss and decreased muscle strength, and it significantly increases the risks of morbidity and mortality in the population with atrophy.
Rui Chen +4 more
doaj +1 more source
Redox control of skeletal muscle atrophy [PDF]
Free Radical Biology and Medicine, 2016 Skeletal muscles comprise the largest organ system in the body and play an essential role in body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important endocrine organ that contributes to the health of numerous body organs.
Scott K. Powers +3 more
openaire +2 more sources
Journal of Cellular and Molecular Medicine, 2021 Obesity is associated with biological dysfunction in skeletal muscle. As a condition of obesity accompanied by muscle mass loss and physical dysfunction, sarcopenic obesity (SO) has become a novel public health problem. Human fibroblast growth factor 19 (
Ai Guo +8 more
semanticscholar +1 more source
Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism [PDF]
International Journal of Molecular Sciences, 2018 Antibiotics lead to increased susceptibility to colonization by pathogenic organisms, with different effects on the host-microbiota relationship. Here, we show that metronidazole treatment of specific pathogen-free (SPF) mice results in a significant increase of the bacterial phylum Proteobacteria in fecal pellets.
Ravikumar Manickam +4 more
openaire +4 more sources
Deubiquitinases in skeletal muscle atrophy [PDF]
The International Journal of Biochemistry & Cell Biology, 2013 The ubiquitin proteasome system plays a critical role in skeletal muscle atrophy. A large body of research has revealed that many ubiquitin ligases are induced and play an important role in mediating the wasting. However, relatively little is known about the roles of deubiquitinases in this process.
openaire +2 more sources
Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling
Annals medicus, 2021 Background: Recent evidence indicates that host-gut microbiota crosstalk has nonnegligible effects on host skeletal muscle, yet gut microbiota-regulating mechanisms remain obscure.
Yixuan Qiu +9 more
semanticscholar +1 more source