Results 41 to 50 of about 352,666 (292)

HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses

Skeletal Muscle, 2018
Background Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy.
Eva Pigna, Alessandra Renzini, Emanuela Greco, Elena Simonazzi, Stefania Fulle, Rosa Mancinelli, Viviana Moresi, Sergio Adamo   +7 more
doaj   +1 more source

Herbal complex 'Buyang Huanwu Tang' improves motor endplate function of denervated-dependent skeletal muscle atrophy in rat [PDF]

Journal of Integrative Neuroscience, 2020
Denervated-dependent skeletal muscle atrophy is a disease induced by skeletal muscle associated peripheral neuro-disconnection. Its specific molecular mechanisms remain unknown.
Lan Zhou, Yu-Fang Huang, Hui Xie, Xiao-Yun Mei, Jun Cao
doaj   +1 more source

Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy

Cell Reports, 2021
SUMMARY Skeletal muscle atrophy is a debilitating condition that occurs with aging and disease, but the underlying mechanisms are incompletely understood. Previous work determined that common transcriptional changes occur in muscle during atrophy induced
Liam C Hunt, F. Graça, V. Pagala, Yong-Dong Wang, Yuxin Li, Zuo-Fei Yuan, Yiping Fan, Myriam Labelle, Junmin Peng, Fabio Demontis   +9 more
semanticscholar   +1 more source

Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model

Pharmaceuticals, 2023
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial.
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, Majid Khazaei, Tyler W. LeBaron   +7 more
doaj   +1 more source

Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control

Molecules, 2021
Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that dramatically increases mortality and morbidity. The alteration of protein homeostasis is generally due to increased protein breakdown while, protein synthesis may also be
Dulce Peris-Moreno, Laura Cussonneau, L. Combaret, C. Polge, D. Taillandier   +4 more
semanticscholar   +1 more source

TWEAK and TRAF6 regulate skeletal muscle atrophy [PDF]

Current Opinion in Clinical Nutrition and Metabolic Care, 2012
To discuss the roles and mechanisms of action of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and tumor necrosis factor receptor-associated factor 6 (TRAF6) in skeletal muscle atrophy.Proinflammatory cytokines are known to mediate muscle atrophy in many chronic disease states.
Ashok, Kumar, Shephali, Bhatnagar, Pradyut K, Paul   +2 more
openaire   +2 more sources

Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy

Frontiers in Immunology, 2021
Background Inflammation may trigger skeletal muscle atrophy induced by cancer cachexia. As a pro-inflammatory factor, interleukin-6 may cause skeletal muscle atrophy, but the underlying molecular mechanisms have not been explored.
Hualin Sun, Junjie Sun, Ming Li, Lei Qian, Lilei Zhang, Ziwei Huang, Yuntian Shen, B. Law, Liang Liu, X. Gu   +9 more
semanticscholar   +1 more source

Disease-Induced Skeletal Muscle Atrophy and Fatigue [PDF]

Medicine & Science in Sports & Exercise, 2016
Numerous health problems, including acute critical illness, cancer, diseases associated with chronic inflammation, and neurological disorders, often result in skeletal muscle weakness and fatigue. Disease-related muscle atrophy and fatigue is an important clinical problem because acquired skeletal muscle weakness can increase the duration of ...
Powers, Scott K., Lynch, Gordon S., Murphy, Kate T., Reid, Michael B., Zijdewind, Inge   +4 more
openaire   +2 more sources

Denervation does not induce muscle atrophy through oxidative stress

European Journal of Translational Myology, 2017
Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness.
Eva Pigna, Emanuela Greco, Giulio Morozzi, Silvia Grottelli, Alessio Rotini, Alba Minelli, Stefania Fulle, Sergio Adamo, Rosa Mancinelli, Ilaria Bellezza, Viviana Moresi   +10 more
doaj   +1 more source

Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Skeletal muscle atrophy occurs as a result of a variety of conditions including aging, disuse, and cachexia. In this study, we show that the transcription factor KLF5 is transiently up-regulated by metabolic and disuse stimulations and plays
Lin Liu, Hiroyuki Koike, Takehito Ono, S. Hayashi, F. Kudo, Atsushi Kaneda, H. Kagechika, I. Manabe, T. Nakashima, Y. Oishi   +9 more
semanticscholar   +1 more source