Results 11 to 20 of about 598,588 (305)
Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery
Pharmaceuticals, 2022 Imiquimod (IMQ) is a potent immune response modifier with antiviral and antitumor properties. IMQ’s low aqueous solubility and unsatisfactory cutaneous permeability limit its formulation into effective dosage forms.
Eleni Panoutsopoulou +3 more
doaj +1 more source
The effect of long-term cigarette smoking on selected skin barrier proteins and lipids
Scientific Reports, 2023 The negative impact of cigarette smoking on the skin includes accelerated aging, pigmentation disorders, and impaired wound healing, but its effect on the skin barrier is not completely understood.
Kristýna Hergesell +5 more
doaj +1 more source
Journal of Lipid Research, 2023 Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer[EOS]) are essential components of the lipid skin barrier, which protects our body from excessive water loss and the penetration of unwanted substances.
Ferdinand Fandrei +12 more
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Scientific Reports, 2022 Overcoming the skin barrier properties efficiently, temporarily, and safely for successful transdermal drug delivery remains a challenge. We synthesized three series of potential skin permeation enhancers derived from natural amino acid derivatives ...
Monika Kopečná +3 more
doaj +1 more source
Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties
Cells, 2023 An intact barrier function of the skin is important in maintaining skin health. The regulation of the skin barrier depends on a multitude of molecular and immunological signaling pathways.
Paola Baker +5 more
doaj +1 more source
Skin-associated adipocytes in skin barrier immunity: A mini-review
Frontiers in Immunology, 2023 The skin contributes critically to health via its role as a barrier tissue against a multitude of external pathogens. The barrier function of the skin largely depends on the uppermost epidermal layer which is reinforced by skin barrier immunity.
Jingyan Guan +3 more
doaj +1 more source
Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]
, 2020 Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung +19 more
core +1 more source
Skin Barrier and Calcium [PDF]
Annals of Dermatology, 2018 Epidermal barrier formation and the maintenance of barrier homeostasis are essential to protect us from the external environments and organisms. Moreover, impaired keratinocytes differentiation and dysfunctional skin barrier can be the primary causes or aggravating factors for many inflammatory skin diseases including atopic dermatitis and psoriasis ...
Sang Eun Lee, Seung Hun Lee
openaire +3 more sources
Gentiana lutea Extract Modulates Ceramide Synthesis in Primary and Psoriasis-Like Keratinocytes
Molecules, 2020 Gentiana lutea is a bitter herb that is traditionally used to improve gastric disorders. Recently, we have shown that Gentiana lutea extract (GE) also modulates the lipid metabolism of human keratinocytes in vitro and in vivo.
Fabian Gendrisch +6 more
doaj +1 more source
Skin barrier immunity and ageing [PDF]
Immunology, 2019 SummaryThe skin is the outermost layer of the body with an extensive surface area of approximately 1·8 m2, and is the first line of defence against a multitude of external pathogens and environmental insults. The skin also has important homeostatic functions such as reducing water loss and contributing to thermoregulation of the body.
Emma S. Chambers +1 more
openaire +4 more sources