Results 11 to 20 of about 3,518,709 (352)

History-dependent switch-like differentiation of keratinocytes in response to skin barrier damage. [PDF]

PLoS Computational Biology
The epidermis is formed by layers of keratinocytes with increasing levels of differentiation towards the outer skin called skin barrier, which protects our body from environmental stressors and dehydration.
Elisa Domíguez-Hüttinger, Eliezer Flores-Garza, José Luis Caldú-Primo, Harley Day, Abihail Roque Ramírez, Reiko J Tanaka   +5 more
doaj   +2 more sources

THE SKIN BARRIER IN SENSITIVE SKIN SYNDROME [PDF]

Journal of IMAB, 2021
Background: Sensitive Skin Syndrome (SSS) is predominantly a self-defined condition without objective pathological findings. The syndrome presents with sudden and easily provoked flushes accompanied by unpleasant sensations like itching, pain or ...
Filka Georgieva
doaj   +1 more source

Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability

Journal of Lipid Research, 2022
Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in epidermal homeostasis and necessary for stratum corneum (SC) barrier function.
Ferdinand Fandrei, Oskar Engberg, Lukáš Opálka, Pavla Jančálková, Petra Pullmannová, Miloš Steinhart, Andrej Kováčik, Kateřina Vávrová, Daniel Huster   +8 more
doaj   +1 more source

Skin-Interfaced Superhydrophobic Insensible Sweat Sensors for Evaluating Body Thermoregulation and Skin Barrier Functions.

ACS Nano, 2023
Monitoring sweat rate is vital for estimating sweat loss and accurately measuring biomarkers of interest. Although various optical or electrical sensors have been developed to monitor the sensible sweat rate, the quantification of the insensible sweat ...
Yangchengyi Liu, Xiaofeng Li, Hanlin Yang, Ping Zhang, Peihe Wang, Yi Sun, Fengzhen Yang, Weiyi Liu, Yujing Li, Yao Tian, Shun Qian, Shangda Chen, H. Cheng, Xiufeng Wang   +13 more
semanticscholar   +1 more source

Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery

Pharmaceuticals, 2022
Imiquimod (IMQ) is a potent immune response modifier with antiviral and antitumor properties. IMQ’s low aqueous solubility and unsatisfactory cutaneous permeability limit its formulation into effective dosage forms.
Eleni Panoutsopoulou, Jarmila Zbytovská, Kateřina Vávrová, Georgios Paraskevopoulos   +3 more
doaj   +1 more source

Staphylococcus aureus causes aberrant epidermal lipid composition and skin barrier dysfunction

Allergy. European Journal of Allergy and Clinical Immunology, 2023
Staphylococcus (S) aureus colonization is known to cause skin barrier disruption in atopic dermatitis (AD) patients. However, it has not been studied how S. aureus induces aberrant epidermal lipid composition and skin barrier dysfunction.
Jihyun Kim, B. Kim, E. Berdyshev, Irina A. Bronova, L. Bin, Jaewoong Bae, Seokjin Kim, Hye-Young Kim, U. Lee, M. Kim, Hyunmi Kim, Jinyoung Lee, C. Hall, Jessica W Hui-Beckman, Yunhee Chang, A. Bronoff, Dasom Hwang, Hae-Young Lee, E. Goleva, K. Ahn, D. Leung   +20 more
semanticscholar   +1 more source

The effect of long-term cigarette smoking on selected skin barrier proteins and lipids

Scientific Reports, 2023
The negative impact of cigarette smoking on the skin includes accelerated aging, pigmentation disorders, and impaired wound healing, but its effect on the skin barrier is not completely understood.
Kristýna Hergesell, Anna Paraskevopoulou, Lukáš Opálka, Vladimír Velebný, Kateřina Vávrová, Iva Dolečková   +5 more
doaj   +1 more source

The intriguing molecular dynamics of Cer[EOS] in rigid skin barrier lipid layers requires improvement of the model

Journal of Lipid Research, 2023
Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer[EOS]) are essential components of the lipid skin barrier, which protects our body from excessive water loss and the penetration of unwanted substances.
Ferdinand Fandrei, Tomáš Havrišák, Lukáš Opálka, Oskar Engberg, Albert A. Smith, Petra Pullmannová, Norbert Kučerka, Veronika Ondrejčeková, Bruno Demé, Lucie Nováková, Miloš Steinhart, Kateřina Vávrová, Daniel Huster   +12 more
doaj   +1 more source

Skin Barrier Function and the Microbiome

International Journal of Molecular Sciences, 2022
Human skin is the largest organ and serves as the first line of defense against environmental factors. The human microbiota is defined as the total microbial community that coexists in the human body, while the microbiome refers to the collective genome ...
Hyun-Ji Lee, Miri Kim
semanticscholar   +1 more source

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

Mucosal Immunology, 2022
Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the ...
Aurélien Trompette, J. Pernot, Olaf Perdijk, Rayed Ali A. Alqahtani, Jaime Santo Domingo, Dolores Camacho-Muñoz, Nicholas C. Wong, A. Kendall, A. Wiederkehr, L. Nicod, A. Nicolaou, Christophe von Garnier, N. Ubags, B. Marsland   +13 more
semanticscholar   +1 more source