A Novel 3D Skin Explant Model to Study Anaerobic Bacterial Infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 Skin infection studies are often limited by financial and ethical constraints, and alternatives, such as monolayer cell culture, do not reflect many cellular processes limiting their application.
Grazieli Maboni +8 more
doaj +13 more sources
Human Skin Explant Preparation and Culture [PDF]
Bio-Protocol, 2022 The ex vivo experimentation with surgically discarded human skin represents a unique methodology amenable for mechanism and pharmacologic agent studies without the involvement of human subjects.
Jessica Shannon +2 more
doaj +4 more sources
Ex-Vivo Skin Explant Culture Is a Model for TSLP-Mediated Skin Barrier Immunity [PDF]
Life, 2021 The skin is the outermost barrier protecting the body from pathogenic invasion and environmental insults. Its breakdown initiates the start of skin inflammation.
Thomas Bauer +5 more
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Prolonged viability of human organotypic skin explant in culture method (hOSEC) [PDF]
Anais Brasileiros de Dermatologia, 2015 BACKGROUND: Currently, the cosmetic industry is overwhelmed in keeping up with the safety assessment of the increasing number of new products entering the market.
Marco Andrey Cipriani Frade +7 more
doaj +7 more sources
Establishment of a striped catfish skin explant model for studying the skin response in Aeromonas hydrophila infections [PDF]
Scientific Reports, 2021 Teleost fish skin serves as the first line of defense against pathogens. The interaction between pathogen and host skin determines the infection outcome. However, the mechanism(s) that modulate infection remain largely unknown.
Ru-Fang Siao +3 more
doaj +2 more sources
Electroporation of embryonic chick skin explant
Medicine in Novel Technology and Devices, 2022 Since the introduction of electroporation a decade ago, the chick embryo has evolved into a powerful system for studying gene regulation and function during development.
Tailin Chen +6 more
doaj +2 more sources
Human skin explant model for the investigation of topical therapeutics. [PDF]
Sci Rep, 2020 AbstractThe development of in vitro and ex vivo models to mimic human illness is important not only for scientific understanding and investigating therapeutic approaches but also to mitigate animal testing and bridge the inter-species translational gap.
Neil JE, Brown MB, Williams AC.
europepmc +4 more sources
A Human Skin Explant Test as a Novel In Vitro Assay for the Detection of Skin Sensitization to Aggregated Monoclonal Antibodies [PDF]
ToxicsIntroduction: Monoclonal antibodies (mAbs) are important therapeutics. However, the enhanced potential for aggregation has become a critical quality parameter during the production of mAbs. Furthermore, mAb aggregation may also present a potential health
Ana Martins-Ribeiro +6 more
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Early skin colonization by Staphylococcus epidermidis and Staphylococcus aureus reveals environment-dependent synergistic effects [PDF]
Frontiers in MicrobiologyIntroductionThe skin microbiome is crucial for skin health and homeostasis. It contributes to immune defense, promotes epidermal differentiation, and supports a robust skin barrier function.
Chrisse Ngari +4 more
doaj +2 more sources
A Tensioned Human Skin Explant Model Used for Preliminary Assessment of Chemexfoliant-Stimulated Bioeffects [PDF]
JID InnovationsA tensioned ex vivo full-thickness human skin explant platform was used to assess the bioeffects arising from application of several commercial chemexfoliation agents.
Michael J. Conneely +11 more
doaj +2 more sources