Results 71 to 80 of about 12,047 (235)

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Stratum Corneum Formation in Auto-Implants and in Explants of Human Skin*

Journal of Investigative Dermatology, 1961
All of the events in epidermal keratinization are not known. The characteristic unidirectional maturation and migration of epidermal cells, however, is an accepted tenet: “As (the generative cells) multiply and their daughter-cells approach the surface, they gradually change their character until their life terminates with the formation of dead ...
openaire   +2 more sources

Comparative transcriptional profiling of key macrophage and fibroblast subpopulations in rheumatoid arthritis‐associated lung disease

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Human skin explant model for Staphylococcus aureus vaccine research

, 2018
Staphylococcus aureus is a major human pathogen and a member of the human skin microbiota. It is capable of infecting nearly every human tissue to cause a wide spectrum of disease that includes skin and soft tissue infection, infective endocarditis ...
OLANIYI, REUBEN OLAYINKA
core  

Activin A Induces Langerhans Cell Differentiation In Vitro and in Human Skin Explants

PLoS ONE, 2008
Langerhans cells (LC) represent a well characterized subset of dendritic cells located in the epidermis of skin and mucosae. In vivo, they originate from resident and blood-borne precursors in the presence of keratinocyte-derived TGFbeta. In vitro, LC can be generated from monocytes in the presence of GM-CSF, IL-4 and TGFbeta. However, the signals that
MUSSO T, SCUTERA S, VERMI, William, DANIELE, Roberta, FORNARO M, CASTAGNOLI C, ALOTTO D, RAVANINI, Maria, CAMBIERI I, SALOGNI, Laura, ELIA AR, GIOVARELLI M, FACCHETTI, Fabio, GIROLOMONI G, SOZZANI, Silvano   +14 more
openaire   +6 more sources

Nutritional and sensory characteristics of local and hybrid East African Highland cooking bananas: Implications for breeding programs

JSFA reports, EarlyView.
Abstract Background Bananas (Musa species) are an important staple food and cash crop in many parts of the world. The East African Highland cooking bananas form the backbone of food security for millions of Ugandans. The demand for high quality cooking bananas is thus closely linked to their sensory characteristics (which drive consumer preference) and
Willy Nelson Kisenyi, Pricilla Marimo, Moses Matovu, Kephas Nowakunda, Ediriisa Mugampoza, Samuel Gafuma, Timothy Omara, Ivan Kiganda   +7 more
wiley   +1 more source

Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant

, 2017
Study of skin penetration and distribution of the drug compounds in the skin is a major challenge in the development of topical drug products for treatment of skin diseases.
Janfelt, Christian, Nina Ø. Knudsen, Eriksson, André H, Christian Janfelt, Anders J. Pedersen, Knudsen, Nina Ø, Isabella S. Sørensen, Nielsen, Mette Marie B, Mortensen, Rasmus W, Mette Marie B. Nielsen, Nielsen, Kim T, Kim T. Nielsen, André H. Eriksson, Rasmus W. Mortensen, Sørensen, Isabella S, Pedersen, Anders J   +15 more
core   +1 more source

Accelerated Barrier Repair in Human Skin Explants Induced with a Plant-Derived PPAR-α Activating Complex via Cooperative Interactions

Clinical, Cosmetic and Investigational Dermatology, 2021
George Majewski,1,2 John Craw,1 Timothy Falla1 1Rodan & Fields, San Francisco, CA, 94105, USA; 2Present Affiliation: Contrast Product Development, Walnut, CA, 91789, USACorrespondence: John CrawRodan & Fields, 60 Spear Street, Suite 600, San Francisco ...
Majewski G, Craw J, Falla T
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