Results 101 to 110 of about 22,499 (245)

Chironomid‐based summer temperature reconstruction of the Eemian–Weichselian transition at Lichtenberg, northern Germany

open access: yesBoreas, EarlyView.
Understanding the temperature variability of past interglacial cycles is essential to predict future climates. We present a new summer temperature reconstruction, based on the subfossil chironomid record from a small palaeolake adjacent to the Middle Palaeolithic site of Lichtenberg, northern Germany. The record spans from the Saalian late glacial over
Sonja Rigterink   +10 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Homo luzonensis and the role of homoplasy in the morphology of hominin insular species

open access: yesCladistics, EarlyView.
Abstract Homo luzonensis lived during the upper Pleistocene in the northern Philippines, east of the Wallace line. The few specimens attributed to this species show a mosaic of plesiomorphies for the genus Homo and apomorphies found in upper Pleistocene Homo species.
Pierre Gousset   +4 more
wiley   +1 more source

Occupational Contact Urticaria, Protein Contact Dermatitis and Concomitant Airway Diseases in the Finnish Register of Occupational Diseases in 2005–2020: Main Causes and Occupations at Risk

open access: yesContact Dermatitis, EarlyView.
This Finnish registry study shows that concomitant occupational asthma and rhinitis are common in patients with occupational contact urticaria or protein contact dermatitis, often sharing the same exposure. When evaluating occupational immediate allergy, both skin and airway symptoms should be considered.
Ville Ojanen   +4 more
wiley   +1 more source

Dentifrices for preventing erosive tooth wear: An in vitro comparative study

open access: yesEuropean Journal of Oral Sciences, EarlyView.
Abstract Erosive tooth wear is a progressive condition that compromises enamel structure and requires preventive strategies. This in vitro study aimed to compare the protective effects of fluoride‐based dentifrices containing various bioactive agents on sound enamel subjected to simulated erosive–abrasive challenges.
Juliellen Luiz da Cunha   +6 more
wiley   +1 more source

Sustainable control of cyathostomin infections in practice

open access: yesEquine Veterinary Education, EarlyView.
Summary Cyathostomins are the most prevalent helminths in horses and are found in nearly all grazing groups. These parasites have been shown to exhibit widespread anthelmintic resistance and can cause clinical disease, so they are a growing concern.
J. B. Matthews, T. S. Mair
wiley   +1 more source

Silent pressure: Unveiling spinal lymphoma in horses and its parallels to other species

open access: yesEquine Veterinary Education, EarlyView.
Summary Though the nervous system is an uncommon location for lymphoma, the disease should remain a differential diagnosis in some cases of ataxia in equids. Diagnosis of lymphoma can be challenging, although a combination of cytology, histopathology and immunophenotyping can aid in definitive diagnosis and therefore more accurately guide treatment and
H. E. Taylor, D. Luethy
wiley   +1 more source

Discovering the Familiar: Exploring Everyday Practice in the Design of Tools and Artefacts

open access: yesInternational Journal of Art &Design Education, EarlyView.
Abstract The design of everyday objects and artefacts, tools and technologies can prove particularly challenging for design. Their very pervasiveness, ease of application and seeming simplicity can mask the complex array of human practice, knowledge and skills that enables their use posing serious implications for critical design research and practice.
Christian Heath, Jason Cleverly
wiley   +1 more source

Livestock aggregated samples for monitoring viruses infecting animals and potentially zoonotic viral pathogens. [PDF]

open access: yesOne Health
Rusiñol M   +13 more
europepmc   +1 more source

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