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Future Oncology, 2018 Aim: SLC7A11 is a gene that encodes a cystine–glutamate antiporter, which has been detected to be overexpressed in various cancers. Thus, we aimed to validate its expression and clinical significance in liver cancer.
Junjun Ling, Wenlei Zhuo, Zhen Yu
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Role of Slc7a11 in Bleomycin-Induced Lung Injury
LungOxidative stress has been implicated in lung injury and repair. We seek to understand how alterations in the plasma redox potential (Eh) of the thiol disulfide couple cysteine (Cys) and cystine (CySS) (Eh Cys/CySS) affect this process. Previously, we reported that Eh Cys/CySS oxidation promotes a pro-fibrotic phenotype in lung fibroblasts and ...
Jeffrey D, Ritzenthaler +4 more
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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis
Science China Life SciencesTumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed.
Chen, Xiong +6 more
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SLC7A11 as a prognostic biomarker for hepatocellular carcinoma.
Journal of Clinical Oncologye16004 Background: Disulfidptosis has been discovered as a mechanism of cell death mediating by SLC7A11. Nonetheless, little is known about the relationship between SLC7A11 and hepatocellular carcinoma (HCC). Methods: The clinical and follow-up data of 84 consecutive HCC cases who met the inclusion criteria from 2016 to 2019 were retrospectively ...
Yuxi Wang +5 more
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Nanomedicine strategies for disulfidptosis activation in SLC7A11-high tumors
Colloids and Surfaces B: BiointerfacesDisulfidptosis is a recently identified form of regulated cell death (RCD) characterized by aberrant disulfide bond accumulation and cytoskeletal collapse under conditions of redox imbalance. SLC7A11-overexpressing tumors are uniquely susceptible to this pathway due to their elevated cystine uptake and dependence on glucose-driven NADPH production for ...
Zhanzheng Ye +6 more
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SLC7A11 and NLRP1 in non-small cell lung cancer
Clinica Chimica ActaTo critically evaluate SLC7A11 (solute carrier family 7 member 11) and NLRP1 (NOD-like receptor family pyrin domain containing 1) as clinical laboratory biomarkers in NSCLC, with emphasis on preanalytical control, assay selection/validation, and decision-use cases. Non-small cell lung cancer (NSCLC) requires strong and standard biomarkers for diagnosis,
Abida, Khan +7 more
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Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation
Nature Chemical BiologyThe mechanism of ferroptosis propagation is still unclear. Here our results indicate that the cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation.
Hai-Liang Zhang +11 more
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Depletion of SLC7A11 Sensitizes Nasopharyngeal Carcinoma Cells to Ionizing Radiation
Protein & Peptide LettersBackground: Radiotherapy is the primary treatment choice for Nasopharyngeal Carcinoma (NPC). However, its efficacy is compromised due to radioresistance. Ferroptosis, a novel iron-dependent regulated cell death induced by Ionizing Radiation (IR), plays a role in promoting cancer cell death.
Fan, Yang +5 more
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