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Nanomedicine strategies for disulfidptosis activation in SLC7A11-high tumors
Colloids and Surfaces B: BiointerfacesDisulfidptosis is a recently identified form of regulated cell death (RCD) characterized by aberrant disulfide bond accumulation and cytoskeletal collapse under conditions of redox imbalance. SLC7A11-overexpressing tumors are uniquely susceptible to this pathway due to their elevated cystine uptake and dependence on glucose-driven NADPH production for ...
Zhanzheng Ye +6 more
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SLC7A11 and NLRP1 in non-small cell lung cancer
Clinica Chimica ActaTo critically evaluate SLC7A11 (solute carrier family 7 member 11) and NLRP1 (NOD-like receptor family pyrin domain containing 1) as clinical laboratory biomarkers in NSCLC, with emphasis on preanalytical control, assay selection/validation, and decision-use cases. Non-small cell lung cancer (NSCLC) requires strong and standard biomarkers for diagnosis,
Abida, Khan +7 more
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Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation
Nature Chemical BiologyThe mechanism of ferroptosis propagation is still unclear. Here our results indicate that the cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation.
Hai-Liang Zhang +11 more
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Depletion of SLC7A11 Sensitizes Nasopharyngeal Carcinoma Cells to Ionizing Radiation
Protein & Peptide LettersBackground: Radiotherapy is the primary treatment choice for Nasopharyngeal Carcinoma (NPC). However, its efficacy is compromised due to radioresistance. Ferroptosis, a novel iron-dependent regulated cell death induced by Ionizing Radiation (IR), plays a role in promoting cancer cell death.
Fan, Yang +5 more
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Research progress of cysteine transporter SLC7A11 in endocrine and metabolic diseases
Molecular Biology ReportsSLC7A11, often called xCT, belongs to the SLC family of transporters, which mediates the cellular influx of cystine and the efflux of glutamate. These transport processes are crucial for synthesizing GSH, enhancing the cell's ability to mitigate oxidative stress (OS).
Jiaqi Chen, Mengzhu Yuan, Jianping Wang
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