Results 251 to 260 of about 23,034 (273)

The Role of SLC7A11 in Cancer: Friend or Foe?

Cancers, 2022
SLC7A11 controls the uptake of extracellular cystine in exchange for glutamate at a ratio of 1:1, and it is overexpressed in a variety of tumours. Accumulating evidence has shown that the expression of SLC7A11 is fine-tuned at multiple levels, and plays diverse functional and pharmacological roles in tumours, such as cellular redox homeostasis, cell ...
Li, Sijia, Lu, Zhenyao, Sun, Runbin, Guo, Suhan, Gao, Fangfang, Cao, Bei, Aa, Jiye   +6 more
exaly   +3 more sources

SLC7A11: the Achilles heel of tumor?

Frontiers in Immunology
The non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc- is composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the primary functional component responsible for cystine uptake and glutathione biosynthesis.
Yulang Jiang, Mingyu Sun
exaly   +4 more sources

Role of SLC7A11/xCT in Ovarian Cancer

International Journal of Molecular Sciences
Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage of the disease as well as a high recurrence rate due to the occurrence of chemotherapy resistance. In fact, chemoresistance weakens the therapeutic effects, worsening the outcome of this pathology.
Sonia Fantone, Federica Piani, Fabiola Olivieri   +2 more
exaly   +4 more sources

The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer [PDF]

Frontiers in Oncology, 2022
SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress and is, therefore, critical to cell growth, proliferation, and metabolism.
Kathleen E Delgiorno
exaly   +4 more sources

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Antisense lncRNA As-SLC7A11 suppresses epithelial ovarian cancer progression mainly by targeting SLC7A11.

Die Pharmazie, 2017
Antisense lncRNAs play a key role in the progression of multiple cancers. Thus, it is important to elucidate the function and mechanism of antisense lncRNAs, which may play a role in the treatment of epithelial ovarian cancer (EOC). In the current study, for the first time, we showed that the level of As-SLC7A11 was markedly reduced in EOC cancer ...
Jinjin Yuan, Jinjin Yuan, Zongwen Liu, Zongwen Liu, Rui Song, Rui Song   +2 more
openaire   +2 more sources

Ferroptosis and Neurodegenerative Diseases: Insights into the Regulatory Roles of SLC7A11

Cellular and Molecular Neurobiology, 2023
Programed cell death plays a key role in promoting human development and maintaining homeostasis. Ferroptosis is a recently identified pattern of programmed cell death that is closely associated with the onset and progression of neurodegenerative diseases. Ferroptosis is mainly caused by the intracellular accumulation of iron-dependent lipid peroxides.
Chen Wang, Haihui Liu, Si Xu
exaly   +3 more sources

SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis

Cardiovascular Drugs and Therapy, 2021
Systemic hypertension may induce adverse hypertrophy of the left cardiac ventricle. Pathological cardiac hypertrophy is a common cause of heart failure. We investigated the significance of ferroptosis repressor xCT in hypertrophic cardiomyopathy.xCT expression in angiotensin II (Ang II)-treated mouse hearts and rat cardiomyocytes was determined using ...
Xiyu, Zhang, Cuiting, Zheng, Zhenqiang, Gao, Hongyu, Chen, Kai, Li, Lingling, Wang, Yuanyuan, Zheng, Chunjia, Li, Hongjia, Zhang, Ming, Gong, Hongbing, Zhang, Yan, Meng   +11 more
openaire   +2 more sources

Role of Slc7a11 in Bleomycin-Induced Lung Injury

Lung
Oxidative stress has been implicated in lung injury and repair. We seek to understand how alterations in the plasma redox potential (Eh) of the thiol disulfide couple cysteine (Cys) and cystine (CySS) (Eh Cys/CySS) affect this process. Previously, we reported that Eh Cys/CySS oxidation promotes a pro-fibrotic phenotype in lung fibroblasts and ...
Jeffrey D, Ritzenthaler, Edilson, Torres-Gonzalez, Yvonne, Janssen-Heininger, Walter H, Watson, Jesse, Roman   +4 more
openaire   +2 more sources

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

Science China Life Sciences
Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed.
Chen, Xiong, Hong, Ling, Yingdan, Huang, Hanzhi, Dong, Bangxiang, Xie, Qian, Hao, Xiang, Zhou   +6 more
openaire   +2 more sources

SLC7A11 as a prognostic biomarker for hepatocellular carcinoma.

Journal of Clinical Oncology
e16004 Background: Disulfidptosis has been discovered as a mechanism of cell death mediating by SLC7A11. Nonetheless, little is known about the relationship between SLC7A11 and hepatocellular carcinoma (HCC). Methods: The clinical and follow-up data of 84 consecutive HCC cases who met the inclusion criteria from 2016 to 2019 were retrospectively ...
Yuxi Wang, Xi Li, Ya Zhou, Xiao Meng, Ying Wang, Xiaomei Liu   +5 more
openaire   +1 more source