Results 231 to 240 of about 20,364 (275)

Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Kaempferol has been shown to be beneficial in the treatment of Alzheimer's disease (AD) in animal models. However, the action mechanism remains unclear. AKR1B1 has been identified as a target of kaempferol, initially suggested by the Therapeutic Target Database, DrugBank, and PubChem, and subsequently confirmed through experimental validation.
Le Li, Manying Yang, Jiale Tao, Yonghong Zhao, Na Zhao, Shiguo Sun   +5 more
wiley   +1 more source

Ubiquitination-dependent regulation of ferroptosis in ischemic heart and brain. [PDF]

Redox Biol
Zhang YY, Long XY, Tian J, Luo XJ, Peng J.   +4 more
europepmc   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Druggable β-catenin palmitoyl-switch coordinates immune evasion via immunogenic ferroptosis resistance and PD-L1-mediated immunosuppression. [PDF]

Cell Rep Med
Zhang Q, Kong Y, Long Y, Li X, Wang L, Luo Z, Yang X, Xie Y, Yu Q, Yu J, Liang D, Yuan W, Cheng X, Su Y, Cui K, Tian G, He Z, Lan P.   +17 more
europepmc   +1 more source

Progress On Sensorineural Hearing Loss: Mechanisms and Therapies

Sensory Neuroscience, Volume 2, Issue 2, June 2026.
ABSTRACT Hearing loss is the most common disabling disease among humans, which adversely affects human health. Sensorineural hearing loss (SNHL) accounting for approximately 63% of all hearing loss cases. SNHL may be classified into age‐related hearing loss (ARHL), drug‐induced hearing loss (DIHL), noise‐induced hearing loss (NIHL), and sudden ...
Yuan Zhang, Shen Li, Yangfan Zhou, Duopin Li, Junru Ding, Ruifeng Qiao, Yutian Chen, Fanglei Ye, Le Wang, Peipei Li   +9 more
wiley   +1 more source

Targeting the ODC1-YBX1 axis reverses gastric cancer chemoresistance via transcriptional control of SLC7A11-mediated ferroptosis. [PDF]

Cell Death Discov
Li R, Baral S, Zhao F, Zhang C, Zhou J, Li B, Cheng Y, Fang D, Xu Z, Fu Y, Ding J, Tian Z, Zhao S, Wang J, Zi M, Sun L, Jiang X, Sun Q, Wang D.   +18 more
europepmc   +1 more source

Inhibition of PHF1 promotes ferroptosis via IRES‐dependent Snail translation regulation in pancreatic ductal adenocarcinoma

VIEW, Volume 7, Issue 3, June 2026.
PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie, Shan Jin, Yao Zhan, Tiantian Du, Yaqi Dong, Peilong Li, Xiaoshi Zhang, Qiuchen Qi, Jie Gao, Chuanxin Wang   +9 more
wiley   +1 more source

Formononetin alleviated cisplatin-induced acute kidney injury by orchestrating renal tubular cell ferroptosis via PI3K/AKT/NRF2 pathway. [PDF]

Front Pharmacol
Li X, Yan J, Xu Y, Ling Z, Zhang T, Shao X, Xia J, Tang L, Mou S.   +8 more
europepmc   +1 more source

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5‐Mediated Glutamine Metabolism Through YY1

Cancer Science, Volume 117, Issue 6, Page 1748-1765, June 2026.
The CD90‐YY1‐SLC1A5 axis plays a significant role in gastric cancer. CD90 promotes the binding of YY1 to the SLC1A5 promoter. CD90 regulates SLC1A5‐mediated glutamine metabolism and ferroptosis. ABSTRACT CD90 (THY1) is a cell surface glycoprotein that plays a crucial role in the occurrence and development of various malignant tumors.
Zihua Zhou, Siyi Liu, Chenyu Zhang, Jun Deng, Lin Liang, Yanhong Zhou   +5 more
wiley   +1 more source

Inducing Ferroptosis to Enhance Radiotherapy in Head and Neck Cancer: Mechanisms, Radiosensitization Strategies, and Normal Tissue Considerations. [PDF]

Cells
Lee J, Roh JL.
europepmc   +1 more source