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Depletion of SLC7A11 Sensitizes Nasopharyngeal Carcinoma Cells to Ionizing Radiation
Protein & Peptide LettersBackground: Radiotherapy is the primary treatment choice for Nasopharyngeal Carcinoma (NPC). However, its efficacy is compromised due to radioresistance. Ferroptosis, a novel iron-dependent regulated cell death induced by Ionizing Radiation (IR), plays a role in promoting cancer cell death.
Fan, Yang +5 more
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Research progress of cysteine transporter SLC7A11 in endocrine and metabolic diseases
Molecular Biology ReportsSLC7A11, often called xCT, belongs to the SLC family of transporters, which mediates the cellular influx of cystine and the efflux of glutamate. These transport processes are crucial for synthesizing GSH, enhancing the cell's ability to mitigate oxidative stress (OS).
Jiaqi Chen, Mengzhu Yuan, Jianping Wang
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ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis
Journal of Hepatology, 2023Michael Karin +2 more
exaly
Hsa-miR-26a-5p improves OSCC sensitivity to ferroptosis by inhibiting SLC7A11
Archives of Oral Biology, 2023exaly