Results 211 to 220 of about 19,150 (245)

Inducing Ferroptosis to Enhance Radiotherapy in Head and Neck Cancer: Mechanisms, Radiosensitization Strategies, and Normal Tissue Considerations. [PDF]

Cells
Lee J, Roh JL.
europepmc   +1 more source

Bufalin Suppresses Pancreatic Ductal Adenocarcinoma Through ER Stress-Ferroptosis Crosstalk Associated with IP₃R-Linked Ca²⁺ Dysregulation and ATF3/SLC7A11 Regulation. [PDF]

Int J Mol Sci
Yang PW, Li X, Si WM, Zhang Y, Kong XY, Xu XY, Zhu XY, Chen Z.   +7 more
europepmc   +1 more source

Berberine from Tibetan Medicine <i>Dracocephalum tanguticum</i> Maxim Suppresses Colorectal Tumor Growth and Inhibits CD8⁺ T Cells Ferroptosis via the NRF2-SLC7A11-GPX4 Axis. [PDF]

Cancer Manag Res
Wang Y, Zhang Y, Wang Q, Zheng L, Liu Y.
europepmc   +1 more source

Tumor cell ferroptosis in antitumor immunity and immunotherapy efficacy. [PDF]

J Immunother Cancer
Li S, Gajewski T.
europepmc   +1 more source

Astragaloside IV Alleviates Lupus Nephritis by Inhibiting Podocyte Ferroptosis via the PI3K/AKT/Nrf2 Pathway. [PDF]

Drug Des Devel Ther
Tang Z, Cheng L, Li M, Huang C.
europepmc   +1 more source

Inflammatory CD4⁺ T cells can waive NRF2-dependent SLC7A11-mediated cystine uptake by using ASCT1. [PDF]

iScience
Neullens CT, Subramanyam SH, Horneff G, Kallinich T, Huijsmans F, van Loosdregt J, Vastert B, Tenbrock K, Ohl K.   +8 more
europepmc   +1 more source

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

Molecular Cell, 2022
IDO1 oxidizes tryptophan (TRP) to generate kynurenine (KYN), the substrate for 1-carbon and NAD metabolism, and is implicated in pro-cancer pathophysiology and infection biology. However, the mechanistic relationships between IDO1 in amino acid depletion versus product generation have remained a longstanding mystery.
, Simon Newstead, Marion Russier
exaly   +4 more sources

The Role of SLC7A11 in Cancer: Friend or Foe?

Cancers, 2022
SLC7A11 controls the uptake of extracellular cystine in exchange for glutamate at a ratio of 1:1, and it is overexpressed in a variety of tumours. Accumulating evidence has shown that the expression of SLC7A11 is fine-tuned at multiple levels, and plays diverse functional and pharmacological roles in tumours, such as cellular redox homeostasis, cell ...
Suhan Guo, Li Sijia, Cao Bei
exaly   +3 more sources

SLC7A11: the Achilles heel of tumor?

Frontiers in Immunology
The non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc- is composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the primary functional component responsible for cystine uptake and glutathione biosynthesis.
Yulang Jiang, Sun Mingyu, Jiang Yulang   +2 more
exaly   +4 more sources