Results 211 to 220 of about 21,100 (250)

Quantitative and Targeted Regulation of Ferroptosis in Bladder Cancer: Preclinical Study. [PDF]

J Cell Mol Med
Dong Y, Xu C, Yan B, Mou S, Li C, Liu Y.
europepmc   +1 more source

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1708-1725, October 2026.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan, Shuang Sui, Zhenghua Yang, Kaiwen Zhang, Qiang Hu   +4 more
wiley   +1 more source

E3 Ubiquitin Ligases in MASH‐Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a major cause of progressive liver fibrosis and can ultimately lead to cirrhosis and hepatocellular carcinoma (HCC). MASH‐associated liver fibrosis develops through a complex interplay among lipotoxic hepatocyte injury, oxidative and endoplasmic reticulum stress, inflammatory ...
Ah‐Reum Oh, Yelin Jeong, Young Hoon Jung, Young Un Kim, HyunJoon Gi, Do‐Wan Kim, Young Du Choi, Sang Bae Lee, KyeongJin Kim   +8 more
wiley   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance. [PDF]

Adv Sci (Weinh)
Li Y, Zhang H, Zhou J, Yang S, Cha J, Yan G, Zhao S, Mao B, Ma P.   +8 more
europepmc   +1 more source

Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Metformin suppresses ATF2 expression, activating the PI3K/Akt pathway and promoting Nrf2 nuclear translocation. This upregulates GPX4, inhibiting ferroptosis in trophoblast cells. Erastin blocks system Xc−, depleting GSH and promoting ferroptosis. LY294002 and ML385 inhibit the pathway, validating the mechanism.
Dandan Xia, Yuhui Zhang, Wenjie Liu, Siyu Li, Chenying Zhang, Guangtong She, Huiyan Wang   +6 more
wiley   +1 more source

A glucose metabolism-targeted nanoplatform amplifies disulfidptosis-associated immunogenic cell death in triple-negative breast cancer. [PDF]

Redox Biol
Xu J, Sun Y, Huang B, Zhang Y, Shen H, Zhou Z, Tian M, Zeng T, Wu S, Yin Y.   +9 more
europepmc   +1 more source

Effects of Isorhapontigenin on Cell Viability, Colony-Forming Efficiency, and Ferroptosis via Methyltransferase-Like 14-Mediated m⁶A Modification of Solute Carrier Family 7 Member 11 in Human Epidermal Growth Factor Receptor 2-Enriched and Basal-Like Breast Cancer. [PDF]

Mol Carcinog
Li Z, Zhang Z, Lin X.
europepmc   +1 more source

[Dual inhibition of PSME2 and STAT3 induces ferroptosis in esophageal squamous cell carcinoma cells by regulating the SLC7A11/GPX4 axis]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Qi C, Zhang H, Wu X, Kang Y, Yang J, Zhao D, Gao S, Qi Y.   +7 more
europepmc   +1 more source