Results 191 to 200 of about 23,034 (273)

Ferroptosis-Driven Neuronal Damage Exacerbation in Diabetic Stroke: Implications of SLC7A11 Inhibition. [PDF]

open access: yesCNS Neurosci Ther
Liu S   +13 more
europepmc   +1 more source

Octupolar AIEgens Photosensitizers With Enhanced Molar Absorptivity for Near‐Infrared Phototheranostics

open access: yesAggregate, Volume 7, Issue 5, May 2026.
Symmetry‐guided molecular engineering transforms dipolar AIEgens into octupolar AIEgens (D(A)3) with enhanced NIR‐II absorptivity. The octupolar architecture activates additional S0→S2 transitions and promotes efficient intersystem crossing, leading to strong reactive oxygen species generation.
Haifei Wen   +14 more
wiley   +1 more source

Sestrin2 Mitigates Neuronal Ferroptosis Following Subarachnoid Hemorrhage via Orchestration of the AMPK/PGC1α/Nrf2 Signaling Axis

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
The schematic summarizes SESN2's neuroprotective actions after subarachnoid hemorrhage. SESN2 activates an AMPK/PGC1α/Nrf2 signaling cascade that reduces oxidative stress, suppresses neuronal ferroptosis, and improves functional outcomes; these effects were validated by genetic knockdown and pharmacologic inhibition.
Yi Zhang   +9 more
wiley   +1 more source

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Oxidative Stress and Improves Neurological Outcomes After Traumatic Brain Injury in Mice

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
In a mouse model of traumatic brain injury, transcutaneous auricular vagus nerve stimulation (taVNS) attenuated oxidative stress and improved neurological recovery. taVNS enhanced Nrf‐2/HO‐1–related antioxidant responses, improved behavioral performance, and promoted edema resolution on MRI.
Xiaoxuan Li   +8 more
wiley   +1 more source

RNA binding protein ZFP36L1 promotes ferroptosis in chronic rhinosinusitis by destabilizing CAMK2A mRNA and impairing mitochondrial quality control

open access: yesClinical and Translational Medicine, Volume 16, Issue 5, May 2026.
This graphical abstract illustrates the novel ZFP36L1–CAMK2A regulatory axis in chronic rhinosinusitis (CRS) pathogenesis: 1. Molecular initiation: In nasal epithelial cells, the RNA‐binding protein ZFP36L1 (upregulated in CRS) directly binds to AU‐rich elements (AREs) in the 3′‐untranslated region (3′‐UTR) of CAMK2A mRNA, promoting its degradation and
Jiayi Xiong   +6 more
wiley   +1 more source

Single‐nucleus RNA sequencing reveals ferroptosis as a potential contributor to the pathogenesis of focal cortical dysplasia

open access: yesClinical and Translational Medicine, Volume 16, Issue 5, May 2026.
1. A single‐cell analysis was conducted to investigate the transcriptomic changes in cells within focal cortical dysplasia (FCD). 2. Ferroptosis may play a significant role in the pathogenesis of FCD, potentially contributing to cellular damage and epileptogenesis. 3.
Qingyang Zeng   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy