ETV4 Improves Cerebral Ischemia‐Reperfusion Injury by Restraining YBX1‐GPX4‐Ferroptosis Cascades
Brain and Behavior, Volume 16, Issue 6, June 2026.ABSTRACT Background Cerebral ischemia‐reperfusion injury (CIRI) is a critical pathological process following ischemic stroke, with ferroptosis being increasingly recognized as a key contributor to neuronal damage. However, the regulatory mechanisms, particularly the role of specific transcription factors like E26 transformation‐specific variant 4 (ETV4)
Qian Xu, Faming Deng, Dan Yu
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SLC16A1 Activates the STAT3/SLC7A11 Pathway to Mediate Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. [PDF]
Oncol ResTian C +7 more
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FKBP9 Enhances Colon Cancer Cell Proliferation by Inhibiting GPX4‐Mediated Ferroptosis
Cancer Medicine, Volume 15, Issue 6, June 2026.The significance of FKBP9 as a therapeutic target in colon cancer treatment, providing new avenues for strategies aimed at sensitizing cancer cells to ferroptosis and improving patient outcomes. ABSTRACT Colorectal cancer, a major health issue worldwide, exhibits intricate molecular mechanisms that necessitate further exploration, particularly ...
Jianzhong Deng +6 more
wiley +1 more source
Spermidine Targets Ovarian Granulosa Cells via Activating the FHC/SLC7A11 Axis to Regulate Iron Homeostasis and Ameliorate Iron Overload-Induced Ovarian Dysfunction. [PDF]
Antioxidants (Basel)Niu CY +13 more
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Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.These findings indicate that urinary exosomal miR‐217 promotes podocyte ferroptosis and DKD progression via suppression of the SIRT1/Nrf2 pathway, suggesting a potential therapeutic target for DKD. Abstract Urinary exosomal microRNAs (miRNAs) mediate intercellular communication in diabetic kidney disease (DKD), a leading contributor to end‐stage renal ...
Xin Du +7 more
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Disulfidptosis vs. Ferroptosis: A Comprehensive Review of SLC7A11-Mediated Metal Dyshomeostasis and Cell Death. [PDF]
BiomoleculesTolbatov I, Marrone A.
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Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.Integrated machine learning screening of five gene expression omnibus datasets and 113 algorithm combinations identified three candidate diagnostic biomarkers for neonatal necrotizing enterocolitis: SLC26A3 (downregulated), CCL20, and CXCL5 (both upregulated). Single‐cell RNA sequencing localized CCL20 upregulation predominantly to macrophages.
Xue Liu +5 more
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The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart. [PDF]
Redox RepZhang Y, Xin Y, Zhou J, Yang G, Li S.
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CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.SCI induces significant upregulation of USP5 in neurons. The overexpressed USP5 stabilizes c‐MAF protein expression through its deubiquitinase activity, activating autophagy and accelerating the degradation of autophagic ferritin, thereby mediating neuronal ferroptosis. This ultimately leads to impaired functional recovery in SCI mice.
Shiyang Weng +4 more
wiley +1 more source
Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS. [PDF]
Cell BiosciLin CY, Hsieh WC, Wang SM.
europepmc +1 more source