Results 191 to 200 of about 21,100 (250)

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

Sex differences in ferroptosis-related vulnerability to autism-like deficits in the adolescent medial prefrontal cortex following embryonic valproic acid exposure. [PDF]

Biol Sex Differ
Zhao S, Wang J, Pan Y, Yang Y, Yin Y, Li W, Li J, Feng X.   +7 more
europepmc   +1 more source

Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy

MedComm, Volume 7, Issue 10, October 2026.
Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu, Mengling You, Yi Zeng, Jinglin Zhang, Si Chen, Rong Rong, Xiaobo Xia   +6 more
wiley   +1 more source

Metformin Inhibits Ferroptotic Cell Death by Suppressing Cysteine Deprivation‐Induced Mitochondrial Dysfunction

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic strategy for cancer. Metformin, a widely used biguanide antidiabetic drug, has recently been reported to induce ferroptosis and exert anticancer effects in various malignancies.
Se‐Kyeong Jang, Selim Kim, Gyeongmi Kim, Jungil Hong, In‐Chul Park, Hyeon‐Ok Jin   +5 more
wiley   +1 more source

Inhibition of EphA2 triggers ferroptosis by disrupting USP38mediated SLC7A11 stabilization in chemoresistant gastric cancer. [PDF]

Cell Mol Life Sci
Xiao R, Mo Y, Zhou J, Xu Y, Kang K, Chen Z, Jiang Y, Li C, Feng X, Chen Z, Chen S, Lai C.   +11 more
europepmc   +1 more source

Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling

Phytotherapy Research, Volume 40, Issue 10, Page 5901-5917, October 2026.
Proposed mechanism by which Luteolin (LU) promotes diabetic foot ulcer healing. LU attenuates hyperglycemia‐induced oxidative stress and lipid peroxidation, improves endothelial cell viability, and suppresses ferroptosis through Nrf2‐dependent antioxidant signaling, thereby accelerating angiogenesis and wound repair. ABSTRACT Diabetic foot ulcers (DFUs)
Muhammed Yusuf, Ayfer Busra Benkli, Ramiz Yusuf   +2 more
wiley   +1 more source

Advances in ferroptosis mechanisms and therapeutic potential in head and neck squamous cell carcinoma. [PDF]

Front Cell Dev Biol
Tang L, Lin L, Xu C, Guo H.
europepmc   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, Volume 40, Issue 10, Page 6005-6042, October 2026.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Disulfidptosis as an immunometabolic rheostat in gastrointestinal cancers: tuning the balance between T Cell exhaustion and immunogenic cell death. [PDF]

Front Cell Dev Biol
Li Y, Qiu H, Li Z, Gao X.
europepmc   +1 more source

A Selective Pro‐Oxidant Drives Redox Reprogramming to Induce Ferroptosis and Immune Remodeling in Glioblastoma

Smart Medicine, Volume 5, Issue 5, October 2026.
Rosasina selectively targets glioblastoma by activating the NCOA4‐NOX5 redox pathway, inducing ferroptosis, and remodeling the tumor immune microenvironment through M1‐like macrophage polarization. These coordinated mechanisms suppress tumor growth and establish Rosasina as a promising therapeutic candidate for glioblastoma.
Shilpi Singh, Iteeshree Mohapatra, Katelyn Kim, Raza Ali Naqvi, Devanjan Dey, Laura Mohapatra, Davis Seelig, Afsar R. Naqvi, Amar Singh, Kathleen Boris‐Lawrie, Stefan Kim, Gatikrushna Singh   +11 more
wiley   +1 more source